CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9601
Family Name Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform and Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform inhibitor 5-[6-[(4-methylsulfonylpiperazin-1-yl)methyl]-4-morpholin-4-ylthieno[2,3-d]pyrimidin-2-yl]pyrimidin-2-amine family
No. of Seeds 7 No. of Other Members 1
Family Centroid CFAMM00165057 Functional Category Bioactive
Superfamily Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform and Serine/threonine-protein kinase mTOR Binder Superfamily
Class Class 1154

Cousin Family NamesSeedsMembers
Aurora kinase B and Aurora kinase A Inhibitor CYC116 Family 16 135
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 8 53
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 9 11
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 6 64
Histamine H3 receptor Ligand 2-(1,4'-bipiperidin-1'-yl)thiazol... 2 23
Deoxycytidine kinase inhibitor AGN-PC-07Z9B3 family 2 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 8 6
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 6
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 6 11
DNA-(apurinic or apyrimidinic site) lyase and Neuropeptide S r... 1 4
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 15 8
Serine/threonine-protein kinase Chk1 inhibitor 3-[5-[2-[(4-mor... 2 3
Serine/threonine-protein kinase Chk1 inhibitor 5-[5-(1-methylp... 3 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 9 0
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00396777 CHEMBL1949913 Bioactive 5-[6-[(4-methylpiperazin-1-yl)methyl]-4-morpholin-4-ylthieno[2,3-d]pyrimidin-2-yl]pyrimidin-2-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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