CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM963
Family Name Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 receptor EP4 subtype ligand SureCN4488527 family
No. of Seeds 4 No. of Other Members 20
Family Centroid CFAMM00231570 Functional Category Bioactive
Superfamily Beta-3 adrenergic receptor and Pol polyprotein Binder Superfamily
Class Class 630

Cousin Family NamesSeedsMembers
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Pristinamycin family 2 2
Cannabinoid receptor 1 Ligand Taranabant Family 20 30
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 4 42
Smoothened homolog Inhibitor LDE225 Family 3 76
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Peroxisome proliferator-activated receptor gamma and Peroxisom... 15 94
Aromatase Inhibitor 2-phenyl-3-pyridin-4-ylmethylene-chroman-4... 3 30
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Leukotriene B4 receptor 1 Ligand SB-201993 Family 5 13
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand WIN-5... 12 52
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
RAF proto-oncogene serine/threonine-protein kinase Inhibitor 5... 3 7
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 57
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybe... 10 5
Renin Inhibitor CP-305202 Family 9 30
Acetylcholinesterase Inhibitor Lysicamine Family 2 8
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Neuromedin-K receptor and Substance-K receptor ligand 2-[2-phe... 2 2
Disintegrin and metalloproteinase domain-containing protein 17... 14 9
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 17 14
Vasopressin V1a receptor and Vasopressin V2 receptor ligand [4... 1 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
cAMP-dependent protein kinase type II-alpha regulatory subunit... 2 4
Neuronal acetylcholine receptor subunit beta-4 and Neuronal ac... 1 0
Somatostatin receptor type 5 ligand AGN-PC-080TDB family 10 14
Neuronal acetylcholine receptor subunit alpha-7 ligand 2-[3-cy... 2 5
Cysteinyl leukotriene receptor 1 ligand 4-[(2S)-2-[[7-(quinoli... 6 15
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 13 0
Somatostatin receptor type 5 and Somatostatin receptor type 1 ... 2 8
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Potassium voltage-gated channel subfamily H member 2 and Kappa... 5 33
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Renin inhibitor (1R,5S)-N-cyclopropyl-N-[(2-methoxy-3-methylpy... 2 3
Cysteinyl leukotriene receptor 1 ligand SureCN7808360 family 4 11
Cysteinyl leukotriene receptor 1 ligand SureCN9053715 family 2 11
B2 bradykinin receptor ligand SureCN7012818 family 1 2
Cysteinyl leukotriene receptor 1 ligand AGN-PC-075KCE family 5 33
B2 bradykinin receptor ligand SureCN6640854 family 7 4
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Thromboxane-A synthase and Thromboxane A2 receptor ligand Sure... 5 37
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 7
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 6 4
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
Prostaglandin D2 receptor 2 ligand SureCN137822 family 3 0
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 2 6
Cysteinyl leukotriene receptor 2 and Cysteinyl leukotriene rec... 16 5
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 9 7
Fatty-acid amide hydrolase 1 inhibitor methyl 6-[2-[3-(4-pheny... 8 5
Serine/threonine-protein kinase B-raf inhibitor furan-based co... 6 3
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 1 14
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 2
Cysteinyl leukotriene receptor 1 and Peripheral myelin protein... 1 1
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 4 11
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Proteinase-activated receptor 1 ligand (3R,3aR,4S,5R,6S,7aS)-5... 2 3
Prostaglandin D2 receptor 2 ligand 2-[1-[4-[(4-methoxybenzoyl)... 2 2
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Arachidonate 5-lipoxygenase inhibitor 7-[[3-fluoro-5-(1-hydrox... 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Beta-secretase 1 and Cytochrome P450 3A4 inhibitor N-[(2S,3R)-... 3 7
Peroxisome proliferator-activated receptor gamma and Peroxisom... 3 0
Prostaglandin E synthase inhibitor 3-[4-(3-cyanopropoxy)-3-met... 2 4
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 2
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Beta-2 adrenergic receptor and Beta-3 adrenergic receptor liga... 1 5
Caspase-1 inhibitor (3S)-3-[[2-[3-(naphthalene-2-carbonylamino... 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 3 15
Pol polyprotein inhibitor Tertiary Amide deriv. 58 family 1 0
Proteinase-activated receptor 1 ligand ethyl N-[(1R,3aR,4aR,6R... 1 4
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 4 0
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 3 1
Leukotriene A-4 hydrolase inhibitor SureCN3030546 family 9 1
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 4 7
cGMP-specific 3',5'-cyclic phosphodiesterase and Calcium/calmo... 7 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
Cathepsin E and Cathepsin D inhibitor SureCN2530955 family 3 1
Prothrombin inhibitor AGN-PC-074I2Z family 2 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 3
Hepatocyte growth factor receptor ligand [4-[6-amino-5-[1-(2,6... 5 1
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN8798759 f... 1 0
Butyrylcholinesterase and Muscarinic acetylcholine receptor M2... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00317990 CHEMBL492266 Bioactive AGN-PC-04WWCN

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48692 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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