CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9659
Family Name Lysosomal Pro-X carboxypeptidase inhibitor 1-(4-chloropyridin-2-yl)-1'-[[4-(trifluoromethoxy)phenyl]methyl]spiro[1H-2-benzofuran-3,4'-piperidine] family
No. of Seeds 6 No. of Other Members 1
Family Centroid CFAMM00397086 Functional Category Bioactive
Superfamily Neuronal acetylcholine receptor subunit alpha-4 and Cytochrome P450 1A2 Binder Superfamily
Class Class 1004

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Bepotastine Family 2 2
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
Dihydroorotate dehydrogenase Inhibitor LY214352 Family 2 17
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 11 4
Somatostatin receptor type 2 ligand SureCN4317006 family 10 1
Lysosomal Pro-X carboxypeptidase inhibitor 1-(3,5-dichlorophen... 3 4
Lysosomal Pro-X carboxypeptidase inhibitor 5-(4-chloropyridin-... 2 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 2
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 5
Substance-K receptor ligand 1-[(4Z)-3-(3,4-dichlorophenyl)-4-m... 2 0
Nociceptin receptor and Mu-type opioid receptor ligand (1R,5R)... 2 0


External ID

Functional Category

Molecule Name

CFAMM00397086 CHEMBL1951465 Bioactive 1-(4-chloropyridin-2-yl)-1'-[[4-(trifluoromethoxy)phenyl]methyl]spiro[1H-2-benzofuran-3,4'-piperidine]
CFAMM00397085 CHEMBL1951469 Bioactive 5-(4-chloropyridin-2-yl)-1'-[[4-(trifluoromethoxy)phenyl]methyl]spiro[5H-furo[3,4-b]pyridine-7,4'-piperidine]
CFAMM00397084 CHEMBL1951468 Bioactive 1-(4-chloro-1-oxidopyridin-1-ium-2-yl)-1'-[[4-(trifluoromethoxy)phenyl]methyl]spiro[1H-2-benzofuran-3,4'-piperidine]
CFAMM00397090 CHEMBL1951476 Bioactive 5-(4-chloropyridin-2-yl)-1'-[2-[4-(trifluoromethoxy)phenyl]propan-2-yl]spiro[5H-furo[3,4-b]pyridine-7,4'-piperidine]
CFAMM00397089 CHEMBL1951471 Bioactive 5-(3,5-dichlorophenyl)-1'-[4-(trifluoromethoxy)phenyl]sulfonylspiro[5H-furo[3,4-b]pyridine-7,4'-piperidine]
CFAMM00397088 CHEMBL1951461 Bioactive 5-(3,5-dichlorophenyl)-1'-[[4-(trifluoromethoxy)phenyl]methyl]spiro[5H-furo[3,4-b]pyridine-7,4'-piperidine]

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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