CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9683
Family Name C-C chemokine receptor type 3 and Cytochrome P450 2D6 ligand (3S,4S)-3-[(5-acetyl-4-methyl-1,3-thiazol-2-yl)carbamoylamino]-4-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]-N-methylpiperidine-1-carboxamide family
No. of Seeds 49 No. of Other Members 4
Family Centroid CFAMM00397283 Functional Category Bioactive
Superfamily Cytochrome P450 2D6 and C-C chemokine receptor type 3 Binder Superfamily 2
Class Class 804

Cousin Family NamesSeedsMembers
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[(3S)-3-[(4... 2 2
C-C chemokine receptor type 3 and Cytochrome P450 2D6 ligand 1... 3 0
Proto-oncogene tyrosine-protein kinase LCK and Tyrosine-protei... 3 9


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00397265 CHEMBL429303 Bioactive 1-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(3R,4R)-3-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]-1-(2-oxopropyl)piperidin-4-yl]urea
CFAMM00397278 CHEMBL410959 Bioactive 1-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(3S,4S)-4-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]-1-methylpiperidin-3-yl]urea
CFAMM00397291 CHEMBL251044 Bioactive 1-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(3S,4S)-1-(2-fluoroethyl)-4-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]piperidin-3-yl]urea
CFAMM00397245 CHEMBL400172 Bioactive 1-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(3R,4R)-1-(cyclopentanecarbonyl)-3-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]piperidin-4-yl]urea
CFAMM00397258 CHEMBL251079 Bioactive 1-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(3S,4S)-4-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]piperidin-3-yl]urea
CFAMM00397271 CHEMBL399088 Bioactive 1-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(3S,4S)-4-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]-1-(2-hydroxyethyl)piperidin-3-yl]urea
CFAMM00397284 CHEMBL403742 Bioactive 1-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(3R,4R)-3-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]-1-(oxane-4-carbonyl)piperidin-4-yl]urea
CFAMM00397251 CHEMBL404857 Bioactive 1-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(3S,4S)-1-(cyanomethyl)-4-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]piperidin-3-yl]urea
CFAMM00397277 CHEMBL404416 Bioactive 1-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(3S,4S)-4-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]oxan-3-yl]urea
CFAMM00397290 CHEMBL251045 Bioactive 2-[(3S,4S)-3-[(5-acetyl-4-methyl-1,3-thiazol-2-yl)carbamoylamino]-4-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]piperidin-1-yl]-N,N-dimethylacetamide
CFAMM00397270 CHEMBL404213 Bioactive 1-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(2S,3R)-2-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]oxan-3-yl]urea
CFAMM00397257 CHEMBL251078 Bioactive tert-butyl (3S,4S)-3-[(5-acetyl-4-methyl-1,3-thiazol-2-yl)carbamoylamino]-4-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]piperidine-1-carboxylate
CFAMM00397283 CHEMBL249857 Bioactive (3S,4S)-3-[(5-acetyl-4-methyl-1,3-thiazol-2-yl)carbamoylamino]-4-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]-N-methylpiperidine-1-carboxamide
CFAMM00397296 CHEMBL249058 Bioactive 1-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(3R,4R)-1-(1-acetylpiperidin-4-yl)-3-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]piperidin-4-yl]urea
CFAMM00397250 CHEMBL250262 Bioactive 1-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(3R,4R)-3-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]-1-(2-methylpropanoyl)piperidin-4-yl]urea
CFAMM00397263 CHEMBL400589 Bioactive (3R,4R)-4-[(5-acetyl-4-methyl-1,3-thiazol-2-yl)carbamoylamino]-3-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]-N-methylpiperidine-1-carboxamide
CFAMM00397276 CHEMBL465291 Bioactive 1-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-[6-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]-3,5-dimethyl-2-oxo-1,3-oxazinan-5-yl]urea
CFAMM00397289 CHEMBL403743 Bioactive 1-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(3S,4S)-4-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]-1-(oxane-4-carbonyl)piperidin-3-yl]urea
CFAMM00397256 CHEMBL401115 Bioactive 1-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(3S,4S)-4-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]-1-(2-oxopropyl)piperidin-3-yl]urea
CFAMM00397269 CHEMBL399893 Bioactive 1-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(3S,4S)-1-(1-acetylpiperidin-4-yl)-4-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]piperidin-3-yl]urea
CFAMM00397295 CHEMBL249059 Bioactive 1-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(3R,4R)-3-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]-1-(2-hydroxyethyl)piperidin-4-yl]urea
CFAMM00397282 CHEMBL249858 Bioactive 1-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(3S,4S)-1-[2-(dimethylamino)acetyl]-4-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]piperidin-3-yl]urea
CFAMM00397249 CHEMBL250056 Bioactive 1-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(3S,4R)-3-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]piperidin-4-yl]urea
CFAMM00397275 CHEMBL439253 Bioactive (3S,4S)-3-[(5-acetyl-4-methyl-1,3-thiazol-2-yl)carbamoylamino]-N-ethyl-4-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]piperidine-1-carboxamide
CFAMM00397288 CHEMBL249851 Bioactive 1-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(3S,4S)-1-(cyclopentanecarbonyl)-4-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]piperidin-3-yl]urea
CFAMM00397255 CHEMBL251622 Bioactive 1-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(3R,4R)-1-(2-fluoroethyl)-3-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]piperidin-4-yl]urea
CFAMM00397268 CHEMBL251220 Bioactive 1-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(3S,4S)-4-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]-1-(1-methylpiperidin-4-yl)piperidin-3-yl]urea
CFAMM00397281 CHEMBL400173 Bioactive methyl (3R,4R)-4-[(5-acetyl-4-methyl-1,3-thiazol-2-yl)carbamoylamino]-3-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]piperidine-1-carboxylate
CFAMM00397294 CHEMBL251275 Bioactive 1-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(3R,4R)-3-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]-1-(2-methoxyacetyl)piperidin-4-yl]urea
CFAMM00397248 CHEMBL250054 Bioactive tert-butyl (3R,4R)-4-[(5-acetyl-4-methyl-1,3-thiazol-2-yl)carbamoylamino]-3-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]piperidine-1-carboxylate
CFAMM00397261 CHEMBL400588 Bioactive 1-[(3R,4R)-1-acetyl-3-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]piperidin-4-yl]-3-(5-acetyl-4-methyl-1,3-thiazol-2-yl)urea
CFAMM00397287 CHEMBL249852 Bioactive methyl (3S,4S)-3-[(5-acetyl-4-methyl-1,3-thiazol-2-yl)carbamoylamino]-4-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]piperidine-1-carboxylate
CFAMM00397274 CHEMBL401160 Bioactive 2-[(3R,4R)-4-[(5-acetyl-4-methyl-1,3-thiazol-2-yl)carbamoylamino]-3-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]piperidin-1-yl]-N,N-dimethylacetamide
CFAMM00397254 CHEMBL251623 Bioactive 1-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(3R,4R)-1-(cyclopropylmethyl)-3-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]piperidin-4-yl]urea
CFAMM00397267 CHEMBL398889 Bioactive 1-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(3S,4S)-1-(cyclopropylmethyl)-4-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]piperidin-3-yl]urea
CFAMM00397280 CHEMBL250436 Bioactive 1-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(3R,4R)-3-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]-1-propanoylpiperidin-4-yl]urea
CFAMM00397293 CHEMBL251274 Bioactive 1-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(3R,4R)-1-(cyclopropanecarbonyl)-3-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]piperidin-4-yl]urea
CFAMM00397260 CHEMBL401394 Bioactive 1-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(3R,4R)-3-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]-1-(1-methylpiperidin-4-yl)piperidin-4-yl]urea
CFAMM00397286 CHEMBL249854 Bioactive 1-[(3S,4S)-1-acetyl-4-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]piperidin-3-yl]-3-(5-acetyl-4-methyl-1,3-thiazol-2-yl)urea
CFAMM00397253 CHEMBL399150 Bioactive 1-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(3S,4S)-4-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]-1-(2-methylpropanoyl)piperidin-3-yl]urea
CFAMM00397266 CHEMBL251446 Bioactive (3R,4R)-4-[(5-acetyl-4-methyl-1,3-thiazol-2-yl)carbamoylamino]-N-ethyl-3-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]piperidine-1-carboxamide
CFAMM00397279 CHEMBL250437 Bioactive 1-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(3R,4R)-1-(cyanomethyl)-3-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]piperidin-4-yl]urea
CFAMM00397292 CHEMBL401159 Bioactive 1-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(3R,4R)-1-[2-(dimethylamino)acetyl]-3-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]piperidin-4-yl]urea
CFAMM00397246 CHEMBL251232 Bioactive 1-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(3S,4R)-3-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]oxan-4-yl]urea
CFAMM00397259 CHEMBL249060 Bioactive 1-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(3S,4R)-3-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]-1-methylpiperidin-4-yl]urea
CFAMM00397272 CHEMBL402707 Bioactive 1-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(3S,4S)-4-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]-1-propanoylpiperidin-3-yl]urea
CFAMM00397285 CHEMBL249855 Bioactive 1-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(3S,4S)-4-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]-1-(2-methoxyacetyl)piperidin-3-yl]urea
CFAMM00397252 CHEMBL402708 Bioactive 1-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(3S,4S)-1-(cyclopropanecarbonyl)-4-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]piperidin-3-yl]urea

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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