CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9685
Family Name Cyclin-dependent kinase 4 and Cyclin-dependent kinase 2 inhibitor (4Z)-4-[[(3-hydroxy-4-pyridin-3-ylphenyl)methylamino]methylidene]-6-iodoisoquinoline-1,3-dione family
No. of Seeds 3 No. of Other Members 1
Family Centroid CFAMM00397311 Functional Category Bioactive
Superfamily RAF proto-oncogene serine/threonine-protein kinase Inhibitor 5-(4-hydroxy-2,6-dimethylstyryl)nicotinic Acid Superfamily
Class Class 2367

Cousin Family NamesSeedsMembers
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Coagulation factor X Inhibitor Otamixaban Family 9 21
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 13 26
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 3 28
Vascular endothelial growth factor receptor 2 ligand AGN-PC-05... 2 2
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor SureC... 4 7
Acetylcholinesterase inhibitor CHEMBL1651140 family 4 4
Hydroxycarboxylic acid receptor 2 and Cytochrome P450 2C9 liga... 2 6
Hydroxycarboxylic acid receptor 2 ligand AGN-PC-04RSPS family 4 0
Acetylcholinesterase inhibitor 1,8-dihydroxy-3-(pyridin-1-ium-... 1 0


External ID

Functional Category

Molecule Name

CFAMM00397311 CHEMBL452447 Bioactive (4Z)-4-[[(3-hydroxy-4-pyridin-3-ylphenyl)methylamino]methylidene]-6-iodoisoquinoline-1,3-dione
CFAMM00397309 CHEMBL195470 Bioactive 1-hydroxy-N-[(2R,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]naphthalene-2-carboxamide
CFAMM00397312 CHEMBL477860 Bioactive SureCN3568412

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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