CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9691
Family Name cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A inhibitor 2-[4-(2-chlorophenyl)phenyl]-4-oxo-1H-1,6-naphthyridine-3-carbonitrile family
No. of Seeds 3 No. of Other Members 10
Family Centroid CFAMM00397340 Functional Category Bioactive
Superfamily cAMP and Somatostatin receptor type 2 Binder Superfamily
Class Class 2063

Cousin Family NamesSeedsMembers
Citric Acid family 2 58
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 12
Oestrogen receptor and Estrogen receptor beta Ligand 4-(3-phen... 5 14
DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)... 4 13
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Adenosine receptor A1 and Adenosine receptor A2a ligand NSC658... 8 54
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 9 22
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 8 10
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 30
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 0
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-00CFYH ... 2 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
Potassium voltage-gated channel subfamily H member 2 and 5-hyd... 2 2
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
Proto-oncogene tyrosine-protein kinase receptor Ret ligand Sur... 1 1
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 7 1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 2 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00397340 CHEMBL1957369 Bioactive 2-[4-(2-chlorophenyl)phenyl]-4-oxo-1H-1,6-naphthyridine-3-carbonitrile
CFAMM00397339 CHEMBL1957460 Bioactive 2-[4-(3-chloro-2-methylpyridin-4-yl)phenyl]-4-oxo-1H-1,6-naphthyridine-3-carbonitrile
CFAMM00397344 CHEMBL1955881 Bioactive 4-oxo-2-[4-[2-(trifluoromethyl)phenyl]phenyl]-1H-1,6-naphthyridine-3-carbonitrile

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

25231 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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