CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9697
Family Name cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A inhibitor 5-(6,7-dimethoxycinnolin-4-yl)-3-fluoro-N-propan-2-ylpyridin-2-amine family
No. of Seeds 8 No. of Other Members 3
Family Centroid CFAMM00397397 Functional Category Bioactive
Superfamily cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Binder Superfamily
Class Class 377

Cousin Family NamesSeedsMembers
DNA Binder Primaquine Family 3 245
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 25 40
Aurora kinase B and Aurora kinase A Inhibitor AZD1152 Family 24 11
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Tyrosine kinase Inhibitor PKI166 Family 17 198
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Platelet-derived growth factor receptor alpha and Platelet-der... 6 8
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor beta and Epidermal gro... 3 7
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Proto-oncogene tyrosine-protein kinase Src inhibitor N-(2,4-di... 3 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 15
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
Tyrosine-protein kinase Lck inhibitor AGN-PC-073GX8 family 12 1
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 2 3
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 19 11
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 8 12
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 6 9
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor Sure... 14 8
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 1 0
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 6 8
Proto-oncogene tyrosine-protein kinase Src inhibitor AC1NS5MA ... 3 4
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Cholecystokinin receptor type A ligand AGN-PC-0A9ULH family 8 8
Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... 5 5
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075FPC ... 6 1
Platelet-derived growth factor receptor beta ligand AGN-PC-075... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Corticotropin-releasing factor receptor 1 ligand 2-(2-ethyl-4,... 4 9
Vascular endothelial growth factor receptor 3 and Platelet-der... 8 13
Platelet-derived growth factor receptor beta and Receptor-type... 6 5
Platelet-derived growth factor receptor beta and Receptor-type... 5 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 0
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
Receptor tyrosine-protein kinase erbB-2 and Tyrosine-protein k... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 6
Platelet-derived growth factor receptor beta and Macrophage co... 7 0
Aurora kinase A inhibitor AGN-PC-0760BB family 1 1
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 7 16
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762WF family 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Transient receptor potential cation channel subfamily V member... 2 4
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Hepatocyte growth factor receptor ligand 6-[(1S)-1-[6-(2,3-dih... 1 5
Mitogen-activated protein kinase kinase kinase 11 and Leucine-... 1 2
Histone-lysine N-methyltransferase EHMT2 inhibitor N-(1-cyclop... 1 2
Melanin-concentrating hormone receptor 1 ligand SureCN5431614 ... 1 2
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Vascular endothelial growth factor receptor 2 and Cytochrome P... 2 1
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 1 0
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 2 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 9 2
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Inositol monophosphatase 1 and Prelamin-A/C inhibitor GNF-Pf-3... 1 5
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 1
Epidermal growth factor receptor ligand 4-Anilinoquinazoline d... 2 0
Vascular endothelial growth factor receptor 2 and Serine/threo... 4 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN7... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00397401 CHEMBL2070529 Bioactive N-(2,2-difluoroethyl)-5-(6,7-dimethoxycinnolin-4-yl)-N-ethyl-3-methylpyridin-2-amine
CFAMM00397394 CHEMBL1956236 Bioactive 3-chloro-5-(6,7-dimethoxycinnolin-4-yl)-N-propan-2-ylpyridin-2-amine
CFAMM00397400 CHEMBL1956244 Bioactive 2-[5-(6,7-dimethoxycinnolin-4-yl)-2-(propan-2-ylamino)pyridin-3-yl]propan-2-ol
CFAMM00397393 CHEMBL1956239 Bioactive 3-(difluoromethyl)-5-(6,7-dimethoxycinnolin-4-yl)-N-propan-2-ylpyridin-2-amine
CFAMM00397399 CHEMBL1956245 Bioactive [5-(6,7-dimethoxycinnolin-4-yl)-2-(propan-2-ylamino)pyridin-3-yl]methanol
CFAMM00397392 CHEMBL1956238 Bioactive 3-cyclopropyl-5-(6,7-dimethoxycinnolin-4-yl)-N-propan-2-ylpyridin-2-amine
CFAMM00397397 CHEMBL1956240 Bioactive 5-(6,7-dimethoxycinnolin-4-yl)-3-fluoro-N-propan-2-ylpyridin-2-amine
CFAMM00397402 CHEMBL1956228 Bioactive N-(cyclopropylmethyl)-5-(6,7-dimethoxycinnolin-4-yl)pyridin-2-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

23712 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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