CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9698
Family Name cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A inhibitor 2-[1-[5-(6,7-dimethoxycinnolin-4-yl)-3-methylpyridin-2-yl]piperidin-4-yl]propan-2-ol family
No. of Seeds 8 No. of Other Members 0
Family Centroid CFAMM00397405 Functional Category Bioactive
Superfamily cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Binder Superfamily
Class Class 377

Cousin Family NamesSeedsMembers
DNA Binder Primaquine Family 3 245
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 15
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
Tyrosine-protein kinase Lck inhibitor AGN-PC-073GX8 family 12 1
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
cAMP-specific 3',5'-cyclic phosphodiesterase 4C and cAMP-speci... 12 2
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 19 11
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 8 12
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 6 9
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Proto-oncogene tyrosine-protein kinase Src inhibitor AC1NS5MA ... 3 4
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Cholecystokinin receptor type A ligand AGN-PC-0A9ULH family 8 8
Platelet-derived growth factor receptor beta ligand AGN-PC-075... 3 0
Corticotropin-releasing factor receptor 1 ligand 2-(2-ethyl-4,... 4 9
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 3
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
Receptor tyrosine-protein kinase erbB-2 and Tyrosine-protein k... 1 0
Aurora kinase A inhibitor AGN-PC-0760BB family 1 1
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 7 16
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Transient receptor potential cation channel subfamily V member... 2 4
Hepatocyte growth factor receptor ligand 6-[(1S)-1-[6-(2,3-dih... 1 5
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Vascular endothelial growth factor receptor 2 and Cytochrome P... 2 1
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Inositol monophosphatase 1 and Prelamin-A/C inhibitor GNF-Pf-3... 1 5
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00397406 CHEMBL1956251 Bioactive 2-[1-[3-(difluoromethyl)-5-(6,7-dimethoxycinnolin-4-yl)pyridin-2-yl]piperidin-4-yl]propan-2-ol
CFAMM00397405 CHEMBL1956250 Bioactive 2-[1-[5-(6,7-dimethoxycinnolin-4-yl)-3-methylpyridin-2-yl]piperidin-4-yl]propan-2-ol
CFAMM00397404 CHEMBL1956253 Bioactive 2-[1-[3-cyclopropyl-5-(6,7-dimethoxycinnolin-4-yl)pyridin-2-yl]piperidin-4-yl]propan-2-ol
CFAMM00397411 CHEMBL1956246 Bioactive 1-[5-(6,7-dimethoxycinnolin-4-yl)-3-methylpyridin-2-yl]-4-pyridin-2-ylpiperidin-4-ol
CFAMM00397403 CHEMBL1956252 Bioactive 2-[1-[3-chloro-5-(6,7-dimethoxycinnolin-4-yl)pyridin-2-yl]piperidin-4-yl]propan-2-ol
CFAMM00397410 CHEMBL1956247 Bioactive 1-[3-chloro-5-(6,7-dimethoxycinnolin-4-yl)pyridin-2-yl]-4-pyridin-2-ylpiperidin-4-ol
CFAMM00397409 CHEMBL1956248 Bioactive 4-cyclopropyl-1-[5-(6,7-dimethoxycinnolin-4-yl)-3-methylpyridin-2-yl]piperidin-4-ol
CFAMM00397408 CHEMBL1956249 Bioactive 1-[5-(6,7-dimethoxycinnolin-4-yl)-3-methylpyridin-2-yl]-4-methylpiperidin-4-ol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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