CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9726
Family Name cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A and Dihydroorotate dehydrogenase (quinone), mitochondrial inhibitor 4-oxo-2-[4-[2-(trifluoromethoxy)phenyl]phenyl]-1H-1,6-naphthyridine-3-carbonitrile family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00397343 Functional Category Bioactive
Superfamily cAMP and Somatostatin receptor type 2 Binder Superfamily
Class Class 2063

Cousin Family NamesSeedsMembers
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 67 130
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)... 4 13
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 8 10
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 5
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 10
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
Potassium voltage-gated channel subfamily H member 2 and 5-hyd... 2 2
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
Proto-oncogene tyrosine-protein kinase receptor Ret ligand Sur... 1 1
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 0
Protein kinase C theta type and Protein kinase C delta type in... 10 7


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00397643 CHEMBL1957367 Bioactive 2-[4-[2-(cyanomethoxy)phenyl]phenyl]-4-oxo-1H-1,6-naphthyridine-3-carbonitrile

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27074 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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