CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9729
Family Name Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform and Phosphatidylinositol 3-kinase regulatory subunit alpha inhibitor N-[3-(dimethylamino)propyl]-6-(1H-indazol-4-yl)-8-morpholin-4-ylimidazo[1,2-a]pyrazine-2-carboxamide family
No. of Seeds 3 No. of Other Members 1
Family Centroid CFAMM00317962 Functional Category Bioactive
Superfamily Serine/threonine-protein kinase B-raf and Phosphatidylinositol 3-kinase regulatory subunit alpha Binder Superfamily
Class Class 1024

Cousin Family NamesSeedsMembers
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
Translocator protein Inhibitor Emapunil Family 7 89
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 8 53
GDC-0349 family 44 77
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 37 10
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
PF-4217903 family 14 65
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Serine/threonine-protein kinase mTOR Inhibitor 4-(2-(1h-indol-... 2 15
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 4
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 1 8
Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family 4 8
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 12
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
cGMP-specific 3',5'-cyclic phosphodiesterase and Potassium vol... 13 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN5... 6 24
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07RDWA fa... 1 4
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 46 9
Ephrin type-B receptor 4 ligand SureCN3289519 family 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 13 10
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
Platelet-activating factor receptor ligand 5-methyl-2-[4-(2-me... 1 2
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... 2 10
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... 4 10
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 3
Aurora kinase A and Aurora kinase B inhibitor AGN-PC-09M46L fa... 2 7
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Serine/threonine-protein kinase B-raf inhibitor SureCN3495829 ... 24 0
Serine/threonine-protein kinase B-raf inhibitor SureCN3495787 ... 8 1
Serine/threonine-protein kinase B-raf inhibitor SureCN1013857 ... 9 3
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 27
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 6
Type-1B angiotensin II receptor ligand SureCN683399 family 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
Insulin-like growth factor 1 receptor ligand AGN-PC-09QGLU family 3 1
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07CBUP family 2 3
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Mitogen-activated protein kinase 10 and Transcription factor A... 4 4
Mitogen-activated protein kinase 14 inhibitor N-ethyl-5-methyl... 17 3
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 13 3
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 0
Protein-tyrosine kinase 6 and KH domain-containing, RNA-bindin... 21 6
Heat shock protein HSP 90-beta inhibitor N-[(9R)-4-(3H-imidazo... 1 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Ribosomal protein S6 kinase alpha-3 inhibitor N-(3-ethylimidaz... 2 2
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 11 3
Casein kinase I isoform delta and Casein kinase I isoform gamm... 1 2
3-phosphoinositide-dependent protein kinase 1 and RAC-alpha se... 10 4
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 4 2
Aurora kinase B and Cyclin-dependent kinase 1 inhibitor 7-cycl... 3 16
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 3
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 3 4
Aurora kinase B and Aurora kinase A inhibitor (2S)-1-[4-[[1-[(... 12 4
Transient receptor potential cation channel subfamily V member... 4 0
Aurora kinase A and Aurora kinase B inhibitor [4-[[7-cyclopent... 6 0
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
DNA gyrase subunit B inhibitor 5-[2-(ethylcarbamoyl)-4-[3-(tri... 2 4
Casein kinase II subunit alpha and Homeodomain-interacting pro... 5 0
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-(cyc... 3 0
Cyclin-dependent kinase 2 and Serine/threonine-protein kinase ... 2 2
Mitogen-activated protein kinase 14 inhibitor imidazole 81 family 2 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 12 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Serine/threonine-protein kinase ATR and Serine/threonine-prote... 8 10
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Tyrosine-protein kinase SYK and Cytochrome P450 2D6 inhibitor ... 3 0
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-fluoro... 5 1
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-chloro... 2 0
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 12 3
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 3 0
TGF-beta receptor type-2 and Vascular endothelial growth facto... 2 1
Aurora kinase B and Aurora kinase A inhibitor 6-chloro-2-methy... 2 4
Serine/threonine-protein kinase PLK2 and Serine/threonine-prot... 1 2
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-[(1-... 9 0
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Epidermal growth factor receptor and Receptor tyrosine-protein... 3 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 5 1
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 2 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Aurora kinase B and Aurora kinase A inhibitor 1-cyclohexyl-3-[... 4 0
Aurora kinase A and Aurora kinase B inhibitor N-[(3E)-3-[5-(mo... 3 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 26 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 12 0
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Tyrosine-protein kinase receptor TYRO3 ligand 3-amino-6-(1H-in... 2 3


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26365 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543