CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9734
Family Name TGF-beta receptor type-1 ligand 6-[(5E)-5-(4-methyl-3H-1,3-thiazol-2-ylidene)-2-propylimidazol-4-yl]-1,3-benzothiazole family
No. of Seeds 22 No. of Other Members 9
Family Centroid CFAMM00397691 Functional Category Bioactive
Superfamily Fumarate reductase flavoprotein subunit Inhibitor Thiabendazole Superfamily
Class Class 392

Cousin Family NamesSeedsMembers
Fumarate reductase flavoprotein subunit Inhibitor Thiabendazol... 3 20
Aurora kinase B and Aurora kinase C Inhibitor SNS-314 Family 2 75
Cytochrome P450 26A1 Inhibitor Rambazole Family 7 77
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 4 22
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 1 9
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 6 64
C-C chemokine receptor type 4 Ligand N-(4-tert-butylthiazol-2-... 3 9
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-chlo... 11 20
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-(2-(4-... 25 10
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07ZBLC fa... 3 8
5-hydroxytryptamine receptor 6 ligand AGN-PC-03P3TZ family 6 88
Neuropeptide Y receptor type 5 ligand N-[[(1S,5R)-3-(1-phenyle... 5 1
Vascular endothelial growth factor receptor 2 and Mast/stem ce... 10 27
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Cell division cycle 7-related protein kinase inhibitor AGN-PC-... 6 6
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 27
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 2 18
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 2 0
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
Adenosine receptor A2b and Adenosine receptor A3 ligand 3-[5-(... 4 2
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(1,4-di... 3 3
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 7
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 7 7
Trans-2-enoyl-ACP reductase II inhibitor AGN-PC-01LWZK family 3 0
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Epidermal growth factor receptor and Vascular endothelial grow... 3 1
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 4 5
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 4 1
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor AGN-P... 1 0
Bombesin receptor subtype-3 ligand AGN-PC-07ZCL7 family 1 0


External ID

Functional Category

Molecule Name

CFAMM00397674 CHEMBL2207997 Bioactive 6-[(5E)-2-cyclopropyl-5-(4-methyl-3H-1,3-thiazol-2-ylidene)imidazol-4-yl]-1,3-benzothiazole
CFAMM00397680 CHEMBL2208006 Bioactive 1-[(5E)-4-(1,3-benzothiazol-6-yl)-5-(4-methyl-3H-1,3-thiazol-2-ylidene)imidazol-2-yl]hexan-3-one
CFAMM00397690 CHEMBL2207989 Bioactive 6-[(5E)-2-methyl-5-(4-methyl-3H-1,3-thiazol-2-ylidene)imidazol-4-yl]-1,3-benzothiazole
CFAMM00397696 CHEMBL2208010 Bioactive 5-[(5E)-4-(1,3-benzothiazol-6-yl)-5-(4-methyl-3H-1,3-thiazol-2-ylidene)imidazol-2-yl]pentanamide
CFAMM00397673 CHEMBL2207995 Bioactive 6-[(5E)-2-hexyl-5-(4-methyl-3H-1,3-thiazol-2-ylidene)imidazol-4-yl]-1,3-benzothiazole
CFAMM00397689 CHEMBL2207988 Bioactive 6-[(5E)-5-(4-methyl-3H-1,3-thiazol-2-ylidene)imidazol-4-yl]-1,3-benzothiazole
CFAMM00397679 CHEMBL2207992 Bioactive 6-[(5E)-5-(4-methyl-3H-1,3-thiazol-2-ylidene)-2-propan-2-ylimidazol-4-yl]-1,3-benzothiazole
CFAMM00397702 CHEMBL2208022 Bioactive propan-2-yl N-[[(5E)-4-(1,3-benzothiazol-6-yl)-5-(4-methyl-3H-1,3-thiazol-2-ylidene)imidazol-2-yl]methyl]carbamate
CFAMM00397695 CHEMBL2208011 Bioactive [(5E)-4-(1,3-benzothiazol-6-yl)-5-(4-methyl-3H-1,3-thiazol-2-ylidene)imidazol-2-yl]methyl N-ethylcarbamate
CFAMM00397672 CHEMBL2207998 Bioactive 6-[(5E)-2-cyclopentyl-5-(4-methyl-3H-1,3-thiazol-2-ylidene)imidazol-4-yl]-1,3-benzothiazole
CFAMM00397678 CHEMBL2207993 Bioactive 6-[(5E)-2-(2-methylpropyl)-5-(4-methyl-3H-1,3-thiazol-2-ylidene)imidazol-4-yl]-1,3-benzothiazole
CFAMM00397701 CHEMBL2208237 Bioactive 2-methylpropyl N-[[(5E)-4-(1,3-benzothiazol-6-yl)-5-(4-methyl-3H-1,3-thiazol-2-ylidene)imidazol-2-yl]methyl]carbamate
CFAMM00397694 CHEMBL2208016 Bioactive ethyl N-[[(5E)-4-(1,3-benzothiazol-6-yl)-5-(4-methyl-3H-1,3-thiazol-2-ylidene)imidazol-2-yl]methyl]carbamate
CFAMM00397687 CHEMBL1957675 Bioactive N-[[(5E)-4-(1,3-benzothiazol-6-yl)-5-(4-methyl-3H-1,3-thiazol-2-ylidene)imidazol-2-yl]methyl]butanamide
CFAMM00397677 CHEMBL2207990 Bioactive 6-[(5E)-2-ethyl-5-(4-methyl-3H-1,3-thiazol-2-ylidene)imidazol-4-yl]-1,3-benzothiazole
CFAMM00397693 CHEMBL2208017 Bioactive 3-[[(5E)-4-(1,3-benzothiazol-6-yl)-5-(4-methyl-3H-1,3-thiazol-2-ylidene)imidazol-2-yl]methyl]-1,3-oxazolidin-2-one
CFAMM00397700 CHEMBL2208238 Bioactive 2,2-dimethylpropyl N-[[(5E)-4-(1,3-benzothiazol-6-yl)-5-(4-methyl-3H-1,3-thiazol-2-ylidene)imidazol-2-yl]methyl]carbamate
CFAMM00397676 CHEMBL2208020 Bioactive butyl N-[[(5E)-4-(1,3-benzothiazol-6-yl)-5-(4-methyl-3H-1,3-thiazol-2-ylidene)imidazol-2-yl]methyl]carbamate
CFAMM00397699 CHEMBL2208018 Bioactive methyl N-[[(5E)-4-(1,3-benzothiazol-6-yl)-5-(4-methyl-3H-1,3-thiazol-2-ylidene)imidazol-2-yl]methyl]carbamate
CFAMM00397698 CHEMBL2208019 Bioactive propyl N-[[(5E)-4-(1,3-benzothiazol-6-yl)-5-(4-methyl-3H-1,3-thiazol-2-ylidene)imidazol-2-yl]methyl]carbamate
CFAMM00397675 CHEMBL2207996 Bioactive 6-[(5E)-5-(4-methyl-3H-1,3-thiazol-2-ylidene)-2-(trifluoromethyl)imidazol-4-yl]-1,3-benzothiazole
CFAMM00397691 CHEMBL2207991 Bioactive 6-[(5E)-5-(4-methyl-3H-1,3-thiazol-2-ylidene)-2-propylimidazol-4-yl]-1,3-benzothiazole

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

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Professor in Department of Pharmacy
National University of Singapore, Singapore

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