CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9740
Family Name 5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine receptor 2C ligand [4-[2-(2,4-difluorophenyl)ethyl]piperazin-1-yl]-pyrazolo[1,5-a]pyridin-2-ylmethanone family
No. of Seeds 5 No. of Other Members 4
Family Centroid CFAMM00042215 Functional Category Bioactive
Superfamily 5-hydroxytryptamine receptor 2A and Mitogen-activated protein kinase 14 Binder Superfamily
Class Class 840

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Cannabinoid receptor 1 Ligand Rimonabant Family 20 260
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Prothrombin Inhibitor Ximelegatran Family 8 157
Histidine decarboxylase Inhibitor Bf-derm1 Family 12 95
Neuromedin-K receptor Ligand SB222200 Family 17 235
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Poly [ADP-ribose] polymerase 1 Inhibitor MK-4827 Family 8 43
Hepatocyte growth factor receptor Ligand MK-8033 Family 19 42
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
Interleukin-1 beta and Interleukin-6 Inhibitor Ibudilast Family 2 11
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Substance-P receptor Ligand TAK-637 Family 18 63
Gamma-aminobutyric acid A receptor Ligand Ocinaplon Family 1 10
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
PHA848125 family 13 138
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
D(4) dopamine receptor Ligand Fauc 113 Family 14 96
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Adenosine receptor A1 and Adenosine receptor A2a Ligand FK-838... 4 19
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
Alpha-1A adrenergic receptor Ligand L-771688 Family 8 14
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 5 10
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Transient receptor potential cation channel subfamily V member... 6 23
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
C-C chemokine receptor type 5 Ligand GT-1282 Family 21 14
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Adenosine receptor A3 Ligand 2-phenyl-2h-pyrazolo[4,3-d]pyrimi... 2 7
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
Glutamate receptor 1 Ligand Piriqualone Family 8 67
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 5 22
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family 4 8
Orexin receptor type 2 and Orexin receptor type 1 ligand AGN-P... 7 19
Orexin receptor type 2 and Orexin receptor type 1 ligand [(7R)... 10 10
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 3
Histone deacetylase 3 and Histone deacetylase 6 inhibitor Tria... 20 37
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 2 4
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07ZE3... 6 1
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 3 59
Melanocortin receptor 4 and Melanocortin receptor 3 ligand N-[... 1 0
Survival motor neuron protein and Beta-lactamase inhibitor CHE... 1 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 11
5-hydroxytryptamine receptor 2A ligand AGN-PC-04RTMN family 7 5
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 0
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M8RE fa... 6 1
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07PRSG fa... 6 0
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-09M6D1 family 2 5
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M6OU fa... 8 7
Coagulation factor X and Trypsin-1 inhibitor SureCN3836037 family 5 4
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 2 21
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 1
5-hydroxytryptamine receptor 3A ligand SureCN8035577 family 5 4
Metabotropic glutamate receptor 1 ligand GTPL6334 family 6 4
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Glucocorticoid receptor ligand N-ethyl-2-fluoro-N-[3,3,3-trifl... 16 7
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04SK7R family 3 3
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Substance-K receptor ligand N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)... 2 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 1
Hepatocyte growth factor receptor ligand 9-[[3-methoxypropyl(m... 17 2
Histamine H3 receptor ligand SureCN1857507 family 1 4
Cannabinoid receptor 1 ligand N-[1-[[(1R)-1-[4-(3-chloroindazo... 10 0
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(2-meth... 7 9
Beta-secretase 1 and Beta-secretase 2 inhibitor (5S)-2-amino-5... 3 39
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 3
Histamine H3 receptor ligand N-methyl-N-[(3R)-1-propan-2-ylpyr... 3 1
Coagulation factor X and Coagulation factor IX inhibitor pyraz... 2 2
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 3-... 3 6
Rho-associated protein kinase 2 and Rho-associated protein kin... 2 6
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
Glucagon receptor and Gastric inhibitory polypeptide receptor ... 1 3
Delta-type opioid receptor and Potassium voltage-gated channel... 2 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 1
cAMP-dependent protein kinase catalytic subunit PRKX and Rho-a... 1 1
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Lysosomal Pro-X carboxypeptidase inhibitor [(3S,4R)-1-tert-but... 20 13
Calcitonin gene-related peptide type 1 receptor ligand 3-[1-[4... 5 3
Hepatocyte growth factor receptor ligand 5-(3-methyl-1,2-thiaz... 5 2
Lysosomal Pro-X carboxypeptidase inhibitor [(1R,2R,4S)-4-amino... 9 0
Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... 20 2
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (2... 16 5
Coagulation factor X inhibitor AGN-PC-02WFR7 family 7 13
Melanin-concentrating hormone receptor 1 ligand N-[(3S)-1-[[(3... 2 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Di... 2 3
Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
Coagulation factor X and Prothrombin inhibitor SureCN5819494 f... 5 8
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 6 0
Fatty-acid amide hydrolase 1 inhibitor 1-[3-[4-(6-phenylhexyl)... 1 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 2 3
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
Metabotropic glutamate receptor 5 ligand 5-(4-chlorophenyl)-1,... 3 1
Tankyrase-1 inhibitor N-[4-[(4S)-5,5-dimethyl-2-oxo-4-phenyl-1... 3 2
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 1
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor (2... 5 5
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Histone deacetylase 1 inhibitor (2S)-N'-hydroxy-2-(pyridine-2-... 3 0
Metabotropic glutamate receptor 1 ligand 4-[1-(2-fluoropyridin... 1 0
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Cannabinoid receptor 1 ligand AGN-PC-07R6QU family 4 2
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
D(4) dopamine receptor and D(1A) dopamine receptor ligand 3-[[... 1 0
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 1 0
Cannabinoid receptor 1 ligand AGN-PC-07NHJ5 family 9 1
Vasopressin V2 receptor and Vasopressin V1a receptor ligand (2... 1 0
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
D(3) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 2 0
Metabotropic glutamate receptor 1 ligand AGN-PC-07CPMZ family 1 0
Cannabinoid receptor 1 ligand AGN-PC-07R5TU family 11 0
Cannabinoid receptor 1 ligand AGN-PC-07R6O8 family 5 2
Cannabinoid receptor 1 ligand AGN-PC-07R6QS family 5 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R6UP family 2 0
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 3 2
TGF-beta receptor type-1 ligand N-(3-cyanophenyl)-2-[3-(6-meth... 4 5
Tyrosine-protein kinase receptor TYRO3 ligand 3-amino-6-(1H-in... 2 3
TGF-beta receptor type-1 ligand Methyl 4-(4-(3-(pyridin-2-yl)-... 1 2
Prolyl endopeptidase inhibitor 4-phenyl-1-[(2S,4S)-4-(4-pyridi... 2 1
Metabotropic glutamate receptor 5 ligand 3-methyl-1-[2-[3-(tri... 3 1
C-C chemokine receptor type 3 ligand AGN-PC-046Y2D family 1 1
C-C chemokine receptor type 3 ligand 4-[[2-(4-chlorophenyl)eth... 2 1
Vascular endothelial growth factor receptor 2 and Vascular end... 5 9
Vascular endothelial growth factor receptor 2 and Vascular end... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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