| Cousin Family Names | Seeds | Members |
|---|
| Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... | 5 | 644 |
| Mast/stem cell growth factor receptor Kit and Abelson tyrosine... | 6 | 537 |
| Omega 1 Benzodiazepine receptor Ligand Zaleplon Family | 6 | 589 |
| 5-hydroxytryptamine receptor 3A Ligand Granisetron Family | 26 | 212 |
| Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... | 5 | 129 |
| Calcitonin gene-related peptide type 1 receptor Ligand Telcage... | 25 | 124 |
| HER Inhibitor AC480 Family | 4 | 67 |
| Dipeptidyl peptidase 4 Inhibitor Linagliptin Family | 10 | 81 |
| Translocator protein Inhibitor Emapunil Family | 7 | 89 |
| Protein kinase C alpha type and Protein kinase C beta type Inh... | 16 | 86 |
| Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family | 53 | 580 |
| Gamma-aminobutyric acid A receptor Ligand Ocinaplon Family | 1 | 10 |
| Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... | 13 | 55 |
| Histone deacetylase 6 Inhibitor ACY-1215 Family | 10 | 230 |
| PHA848125 family | 13 | 138 |
| Smoothened homolog Inhibitor LY2940680 Family | 3 | 18 |
| JAK Inhibitor Momelotinib Family | 33 | 83 |
| Platelet activating factor, putative Inhibitor ABT-491 Family | 22 | 62 |
| Corticotropin-releasing factor receptor 1 Ligand R121919 Family | 26 | 84 |
| Vascular endothelial growth factor receptor 1 and Vascular end... | 6 | 23 |
| cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Cartazo... | 11 | 105 |
| Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... | 19 | 165 |
| 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... | 19 | 103 |
| Metabotropic glutamate receptor 5 Ligand N-(1,4-diphenyl-1h-py... | 3 | 35 |
| Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... | 28 | 47 |
| Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... | 8 | 11 |
| RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... | 219 | 124 |
| Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... | 4 | 31 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 24 | 79 |
| Progesterone receptor Ligand GSK-325971A Family | 1 | 13 |
| Metabotropic glutamate receptor 5 Ligand N-(1,3-diphenyl-1h-py... | 6 | 37 |
| RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... | 20 | 90 |
| Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... | 7 | 77 |
| Prothrombin inhibitor 2-[(2S)-1-[(2R)-2-amino-3-phenylpropanoy... | 3 | 16 |
| 5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... | 8 | 12 |
| Protein farnesyltransferase/geranylgeranyltransferase type-1 s... | 2 | 4 |
| Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... | 1 | 8 |
| Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZYJE fa... | 15 | 5 |
| Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family | 4 | 8 |
| Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... | 8 | 7 |
| Orexin receptor type 2 and Orexin receptor type 1 ligand [(7R)... | 10 | 10 |
| Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... | 2 | 3 |
| Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... | 5 | 10 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... | 4 | 2 |
| Mitogen-activated protein kinase 14 inhibitor SureCN3632376 fa... | 10 | 5 |
| Mitogen-activated protein kinase 13 inhibitor N-cyclopropyl-3-... | 16 | 40 |
| Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... | 3 | 18 |
| Adenosine receptor A3 ligand AGN-PC-07N4XX family | 6 | 10 |
| Adenosine receptor A3 and Adenosine receptor A1 ligand AGN-PC-... | 5 | 1 |
| Orexin receptor type 1 and Orexin receptor type 2 ligand AGN-P... | 2 | 24 |
| Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07ZE3... | 6 | 1 |
| Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07RDWA fa... | 1 | 4 |
| Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... | 46 | 9 |
| Platelet-activating factor receptor ligand SureCN9384429 family | 11 | 3 |
| Prothrombin and Histone-lysine N-methyltransferase 2A inhibito... | 1 | 7 |
| Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... | 6 | 1 |
| Smoothened homolog inhibitor SureCN1091571 family | 2 | 2 |
| Substance-P receptor ligand (3R,4S)-N-[[3,5-bis(trifluoromethy... | 3 | 7 |
| Transient receptor potential cation channel subfamily V member... | 1 | 4 |
| Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... | 3 | 7 |
| Cathepsin K and Potassium voltage-gated channel subfamily H me... | 4 | 7 |
| TGF-beta receptor type-1 ligand 6-[4-ethyl-2-(6-methylpyridin-... | 9 | 11 |
| Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... | 4 | 10 |
| RAC-alpha serine/threonine-protein kinase and Proline-rich AKT... | 2 | 4 |
| Mitogen-activated protein kinase kinase kinase kinase 5 and Du... | 1 | 18 |
| Cell division cycle 7-related protein kinase inhibitor pyrrolo... | 4 | 10 |
| Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... | 5 | 8 |
| Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M6OU fa... | 8 | 7 |
| Mitogen-activated protein kinase 14 inhibitor AGN-PC-069K8I fa... | 12 | 3 |
| Type-1 angiotensin II receptor and Type-2 angiotensin II recep... | 3 | 6 |
| Adenosine receptor A2a ligand AGN-PC-077RWY family | 4 | 5 |
| Tyrosine-protein kinase JAK2 inhibitor N-[2-(3-chlorophenyl)-5... | 2 | 11 |
| Coagulation factor X and Trypsin-1 inhibitor SureCN3836037 family | 5 | 4 |
| Prothrombin and Survival motor neuron protein inhibitor CHEMBL... | 2 | 14 |
| Survival motor neuron protein and Muscleblind-like protein 1 i... | 1 | 3 |
| Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand 5-(2-... | 6 | 83 |
| Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... | 2 | 0 |
| Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... | 1 | 1 |
| Aurora kinase A inhibitor AGN-PC-00EHLC family | 1 | 0 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 3 | 1 |
| Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... | 34 | 4 |
| Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family | 8 | 15 |
| Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07CBUP family | 2 | 3 |
| Calcitonin gene-related peptide type 1 receptor ligand SureCN2... | 2 | 1 |
| MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... | 14 | 0 |
| Mitogen-activated protein kinase 14 inhibitor N-ethyl-5-methyl... | 17 | 3 |
| Mitogen-activated protein kinase 14 and Mitogen-activated prot... | 13 | 3 |
| Fatty-acid amide hydrolase 1 inhibitor [5-(4-chlorophenyl)tria... | 2 | 2 |
| Beta-secretase 1 and Beta-secretase 2 inhibitor (5S)-2-amino-5... | 3 | 39 |
| Coagulation factor X inhibitor AGN-PC-0749BY family | 5 | 9 |
| Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... | 14 | 2 |
| TGF-beta receptor type-1 ligand 3-[[3-(6-methylpyridin-2-yl)-4... | 1 | 0 |
| Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... | 2 | 0 |
| Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... | 2 | 1 |
| Protein-tyrosine kinase 6 and KH domain-containing, RNA-bindin... | 21 | 6 |
| Coagulation factor X and Coagulation factor IX inhibitor pyraz... | 6 | 1 |
| Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 5-(2-... | 12 | 1 |
| Hepatocyte growth factor receptor ligand 5-[[6-(1-methylpyrazo... | 4 | 0 |
| Hepatocyte growth factor receptor ligand 5-[(6-phenyl-[1,2,4]t... | 6 | 2 |
| Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... | 11 | 3 |
| 3-phosphoinositide-dependent protein kinase 1 and RAC-alpha se... | 10 | 4 |
| Prothrombin inhibitor 2-[3-cyano-6-(2,2-difluoro-2-pyridin-2-y... | 3 | 0 |
| Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... | 10 | 0 |
| Mitogen-activated protein kinase 14 inhibitor ethyl N-[4-[5-(m... | 5 | 2 |
| 5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... | 5 | 4 |
| 5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... | 5 | 3 |
| 5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... | 10 | 0 |
| Vascular endothelial growth factor receptor 1 and Vascular end... | 4 | 0 |
| Insulin-like growth factor 1 receptor and Mitogen-activated pr... | 3 | 4 |
| Aurora kinase B and Aurora kinase A inhibitor 4-amino-N-[3-[[(... | 5 | 3 |
| Protein farnesyltransferase/geranylgeranyltransferase type-1 s... | 5 | 3 |
| Aurora kinase B and Aurora kinase A inhibitor (2S)-1-[4-[[1-[(... | 12 | 4 |
| Aurora kinase A and Aurora kinase B inhibitor [4-[[7-cyclopent... | 6 | 0 |
| Substance-P receptor ligand 2-[3,5-bis(trifluoromethyl)phenyl]... | 3 | 1 |
| Egl nine homolog 2 and Egl nine homolog 1 inhibitor 8-[(3-meth... | 3 | 1 |
| Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... | 4 | 2 |
| DNA gyrase subunit B inhibitor 5-[2-(ethylcarbamoyl)-4-[3-(tri... | 2 | 4 |
| Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-(cyc... | 3 | 0 |
| Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (2... | 16 | 5 |
| Renin inhibitor AGN-PC-073MLF family | 7 | 6 |
| Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... | 3 | 1 |
| Tyrosine-protein kinase JAK2 inhibitor N-[3-(3-chlorophenyl)-1... | 12 | 4 |
| Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... | 12 | 0 |
| Tyrosine-protein kinase SYK and Potassium voltage-gated channe... | 1 | 0 |
| Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... | 17 | 0 |
| Tyrosine-protein kinase BTK and Tyrosine-protein kinase ITK/TS... | 4 | 0 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... | 3 | 1 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... | 5 | 6 |
| Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... | 5 | 9 |
| Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... | 3 | 0 |
| P2X purinoceptor 7 inhibitor SureCN109432 family | 10 | 28 |
| P2X purinoceptor 7 inhibitor SureCN109149 family | 8 | 1 |
| P2X purinoceptor 7 inhibitor SureCN9931311 family | 2 | 0 |
| cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... | 3 | 0 |
| Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... | 6 | 0 |
| CGMP-dependent protein kinase inhibitor SureCN14561191 family | 4 | 0 |
| Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... | 7 | 1 |
| Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-fluoro... | 5 | 1 |
| Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... | 4 | 12 |
| Metabotropic glutamate receptor 5 ligand 5-(4-chlorophenyl)-1,... | 3 | 1 |
| Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... | 12 | 3 |
| Serine/threonine-protein kinase PLK2 and Serine/threonine-prot... | 1 | 2 |
| Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-[(1-... | 9 | 0 |
| Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... | 9 | 2 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-[4... | 1 | 1 |
| Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (3... | 2 | 0 |
| Casein kinase II subunit alpha inhibitor CHEMBL401945 family | 12 | 1 |
| Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... | 9 | 2 |
| Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... | 3 | 0 |
| Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... | 2 | 0 |
| Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... | 2 | 0 |
| Alpha-1B adrenergic receptor and Alpha-1A adrenergic receptor ... | 2 | 0 |
| Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... | 5 | 1 |
| Mitogen-activated protein kinase 14 and Mitogen-activated prot... | 2 | 0 |
| Mitogen-activated protein kinase 13 and Mitogen-activated prot... | 4 | 2 |
| Type-1 angiotensin II receptor ligand 2-[(2-ethyl-5,7-dimethyl... | 5 | 3 |
| Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[6-... | 3 | 3 |
| Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... | 4 | 13 |
| RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... | 5 | 1 |
| Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... | 12 | 7 |
| Fatty-acid amide hydrolase 1 and Liver carboxylesterase 1 inhi... | 1 | 0 |
| Somatostatin receptor type 1 ligand AGN-PC-078XQI family | 1 | 0 |
| Mast/stem cell growth factor receptor Kit and Tyrosine-protein... | 4 | 1 |
| Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... | 2 | 1 |
| Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... | 2 | 0 |
| Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-04VNKY family | 1 | 4 |
| Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (3... | 1 | 1 |
| Cannabinoid receptor 1 ligand AGN-PC-07R6O8 family | 5 | 2 |
| Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07B2Q... | 6 | 0 |
| Acyl-CoA desaturase 1 and Acyl-CoA desaturase inhibitor N-(1H-... | 1 | 0 |
| Metabotropic glutamate receptor 5 ligand 2-[4-(4-fluoro-3-meth... | 1 | 0 |
Statistics of CFAM Database |
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
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How to cite our database |
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C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
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Last update by |
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2014.08.29
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