CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9754
Family Name Dipeptidyl peptidase 4 inhibitor SureCN2709139 family
No. of Seeds 5 No. of Other Members 7
Family Centroid CFAMM00299583 Functional Category Bioactive
Superfamily Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 Binder Superfamily 2
Class Class 1787

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor Ligand Felypressin Family 12 820
Sodium channel protein type 5 subunit alpha Ligand Mephenytoin... 5 51
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Glutathione S-transferase Inhibitor Praziquantel Family 5 167
Tumor necrosis factor Inhibitor Thalidomide Family 3 50
Acetylcholinesterase Inhibitor Ambenonium Family 4 71
DNA Binder Procarbazine Family 8 358
Prothrombin Inhibitor Ximelagatran Family 5 48
Melanocortin receptor 4 Ligand Ro-27-3225 Family 6 52
Reverse transcriptase Inhibitor 3-benzylamino-5-ethyl-6-methyl... 2 24
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
72 kDa type IV collagenase Inhibitor Batimastat Family 6 52
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Prothrombin Inhibitor Efegatran Family 9 47
Neutrophil elastase Inhibitor FK-706 Family 8 85
Prothrombin Inhibitor D-leucyl-n-(3-chlorobenzyl)-l-prolinamid... 18 168
Prothrombin Inhibitor D-leucyl-n-(4-carbamimidoylbenzyl)-l-pro... 13 44
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Dipeptidyl peptidase 4 Inhibitor N4-(4-chlorobenzyl)-2,4-diami... 10 22
Substance-P receptor Ligand [sar9,met(o2)11]-sp Family 34 9
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 2 0
Dipeptidyl peptidase 4 inhibitor (2S)-1-[(2S,4S,5S)-4-(1,3-dih... 3 14
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 5 3
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-2-[... 14 4
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 3
Prolyl endopeptidase inhibitor (2R)-1-[(2S)-1-[3-[(2R)-2-acety... 15 9
Cathepsin K and Cathepsin S inhibitor 1-benzyl-3-[(2S)-1-[[cya... 1 0
Dipeptidyl peptidase 8 inhibitor (2S)-2-amino-4-[4-[bis(4-fluo... 2 9
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (2... 1 1
Dipeptidyl peptidase 4 inhibitor (2S)-1-[(2S,4S)-4-anilinopyrr... 2 13
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor (2... 3 10
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 4 1
Dipeptidyl peptidase 4 inhibitor 4-cyano-N-[4-[(2S)-2-cyanopyr... 1 1
P2X purinoceptor 7 inhibitor SureCN8516206 family 5 1
P2X purinoceptor 7 inhibitor (2S)-N-[[2-chloro-3-(trifluoromet... 3 0
P2X purinoceptor 7 inhibitor (4S)-3-methyl-N-[[2-methyl-3-(tri... 3 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor [(... 2 23
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 3 1
Dipeptidyl peptidase 4 inhibitor 4-[4-[(3S,5S)-5-(1,3-thiazoli... 3 2
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 3 0
Kappa-type opioid receptor ligand SureCN5629426 family 3 2
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor Su... 1 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 5 5
Dipeptidyl peptidase 4 inhibitor 4-[[(3S,5S)-5-[(2S)-2-cyanopy... 4 12
Prolyl endopeptidase inhibitor 2-{3-[(2s)-4,4-Difluoro-2-(Pyrr... 2 2
Retinal dehydrogenase 1 and 15-hydroxyprostaglandin dehydrogen... 2 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor Su... 6 5
P2X purinoceptor 7 inhibitor SureCN2574353 family 1 1
NS3 inhibitor 6-[[(2S)-1-[[(2S)-1-[(2S)-2-[[1-(cyclopropylamin... 2 0
Dipeptidyl peptidase 4 inhibitor SureCN14523901 family 7 1
Dipeptidyl peptidase 4 inhibitor (2S,4S)-4-fluoro-1-[2-[[(E)-2... 1 0
Dipeptidyl peptidase 4 inhibitor (3R,6S,7aS)-6-amino-5-oxo-6-p... 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00397841 CHEMBL195804 Bioactive (2S)-1-[(2S,4S)-4-(benzylamino)pyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile
CFAMM00397844 CHEMBL228021 Bioactive 4-[[(4-cyanophenyl)methyl-[(3S,5S)-5-(1,3-thiazolidine-3-carbonyl)pyrrolidin-3-yl]amino]methyl]benzonitrile
CFAMM00397837 CHEMBL389848 Bioactive 4-[[butyl-[(3S,5S)-5-(1,3-thiazolidine-3-carbonyl)pyrrolidin-3-yl]amino]methyl]benzonitrile

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27063 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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