CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9778
Family Name CGMP-dependent protein kinase inhibitor AGN-PC-075XJ0 family
No. of Seeds 9 No. of Other Members 1
Family Centroid CFAMM00397973 Functional Category Bioactive
Superfamily Gp29 Inhibitor Tmpyp4 Superfamily
Class Class 1666

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
Acetylcholinesterase Inhibitor Tacrine Family 12 515
D(2) dopamine receptor Ligand Sertindole Family 3 173
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Food vacuoles Inhibitor Mefloquine Family 2 25
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Grt 6005/06 family 4 22
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
D(2) dopamine receptor and D(3) dopamine receptor Ligand L-741... 9 73
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
D(2) dopamine receptor Ligand SLV-314 Family 19 69
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Trypsin Inhibitor 1-benzyl-1h-indole-5-carboxamidine Family 4 3
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand (6-ben... 2 5
D(1B) dopamine receptor and D(2) dopamine receptor Ligand Flut... 1 6
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 18 17
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 6
Metabotropic glutamate receptor 5 Ligand 7-m-tolyl-1,6-naphthy... 4 2
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Protein kinase C theta type and Protein kinase C delta type in... 16 8
Progesterone receptor and Glucocorticoid receptor ligand SureC... 4 2
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
5-hydroxytryptamine receptor 2A and Alpha-1B adrenergic recept... 4 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 1
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 9 3
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 7 14
Substance-K receptor and Cytochrome P450 2D6 ligand 158848-32-... 4 4
Glucocorticoid receptor ligand SureCN5650626 family 17 25
Glucocorticoid receptor ligand SureCN4198717 family 5 0
Glucocorticoid receptor and Androgen receptor ligand AGN-PC-0A... 3 0
Glucocorticoid receptor ligand AGN-PC-0A9RHA family 1 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0
CGMP-dependent protein kinase inhibitor AGN-PC-075XII family 25 7
Renin and Potassium voltage-gated channel subfamily H member 2... 13 11
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
Transporter and Sodium-dependent serotonin transporter inhibit... 2 1
Alpha-2C adrenergic receptor and Alpha-2A adrenergic receptor ... 5 8
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
5-hydroxytryptamine receptor 2A ligand (3R,4R)-3-(2-phenyl-1H-... 1 18
C-C chemokine receptor type 2 ligand SureCN5946889 family 2 6
C-C chemokine receptor type 2 ligand 2-[4-(5-amino-1H-indol-3-... 3 2
C-C chemokine receptor type 2 ligand SureCN5947024 family 11 0
CGMP-dependent protein kinase inhibitor methyl 2-[[4-[5-(4-flu... 6 1
C-C chemokine receptor type 2 ligand (E)-3-(3,4-dichlorophenyl... 3 2
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
Neuronal acetylcholine receptor subunit alpha-7 and 5-hydroxyt... 1 0
D(1A) dopamine receptor and D(3) dopamine receptor ligand RU-2... 3 4
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 0
CGMP-dependent protein kinase inhibitor AGN-PC-075INU family 1 1
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 2 0
CGMP-dependent protein kinase inhibitor 2-[[4-[5-(4-fluorophen... 1 0
CGMP-dependent protein kinase inhibitor AGN-PC-0761UG family 1 2
Nociceptin receptor and Potassium voltage-gated channel subfam... 3 9
CGMP-dependent protein kinase inhibitor AGN-PC-078XQ0 family 1 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 5 7
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 1
Histamine H3 receptor ligand AGN-PC-09M6FC family 1 9
Nociceptin receptor and Mu-type opioid receptor ligand SureCN1... 1 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand (2Z)-... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00397982 CHEMBL371306 Bioactive AGN-PC-075XJ3
CFAMM00397975 CHEMBL199108 Bioactive AGN-PC-075XGT
CFAMM00397981 CHEMBL198492 Bioactive AGN-PC-03XJYR
CFAMM00397974 CHEMBL199189 Bioactive AGN-PC-075XHE
CFAMM00397980 CHEMBL198491 Bioactive AGN-PC-075XIW
CFAMM00397973 CHEMBL197980 Bioactive AGN-PC-075XJ0
CFAMM00397979 CHEMBL198819 Bioactive AGN-PC-075XGS
CFAMM00397977 CHEMBL196278 Bioactive AGN-PC-075XHL
CFAMM00397976 CHEMBL198352 Bioactive AGN-PC-075XHX

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26365 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543