CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9812
Family Name RAC-alpha serine/threonine-protein kinase inhibitor N-[(2S)-1-(1H-indol-3-yl)-3-(5-thieno[2,3-c]pyridin-2-ylpyridin-3-yl)oxypropan-2-yl]thieno[2,3-c]pyridin-2-amine family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00398141 Functional Category Bioactive
Superfamily Protein kinase C theta type and Protein kinase C delta type Binder Superfamily 2
Class Class 3208

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
Melatonin receptor type 1A Ligand Melatonin Family 20 988
DNA Binder Elliptinium Acetate Family 11 116
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
PF-02545920 family 16 140
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Platelet-derived growth factor receptor alpha and Platelet-der... 6 8
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
D(2) dopamine receptor Ligand SLV-314 Family 19 69
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 36 18
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 6 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 8 8
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 11 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Somatostatin receptor type 2 ligand SureCN4313450 family 2 25
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Beta-3 adrenergic receptor and Beta-2 adrenergic receptor liga... 16 2
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 3 0
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
Serine/threonine-protein kinase B-raf inhibitor pyrrole-based ... 2 0
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 2 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 3 1
Neuronal acetylcholine receptor subunit alpha-7 ligand 5-[6-[[... 1 0
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
D(2) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 1 0
Sodium-dependent serotonin transporter inhibitor (2S)-1-[(2S,4... 7 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 0
RAC-alpha serine/threonine-protein kinase inhibitor Isoquinoli... 1 0
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 2 0
Protein kinase C theta type and Protein kinase C delta type in... 10 7
B2 bradykinin receptor ligand SureCN13145573 family 7 6
B2 bradykinin receptor and Cytochrome P450 3A4 ligand SureCN15... 4 0
TGF-beta receptor type-1 ligand SureCN373216 family 3 14
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 6 0
DNA gyrase subunit B and DNA gyrase subunit A inhibitor (1S,2R... 4 6
Indoles Metabolite 6-Methoxy-3-(2-thiazolyl)-1H-indole Family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00398141 CHEMBL211281 Bioactive N-[(2S)-1-(1H-indol-3-yl)-3-(5-thieno[2,3-c]pyridin-2-ylpyridin-3-yl)oxypropan-2-yl]thieno[2,3-c]pyridin-2-amine
CFAMM00398139 CHEMBL209503 Bioactive 6-[5-[(2S)-3-(1H-indol-3-yl)-2-[(2-oxo-3H-1,3-benzothiazol-6-yl)amino]propoxy]pyridin-3-yl]-3H-1,3-benzothiazol-2-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26200 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543