CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9832
Family Name Caspase-1 and Caspase-8 inhibitor (4S,7S,11aS)-7-benzamido-N-[(3S)-2-hydroxy-5-oxooxolan-3-yl]-6-oxo-1,2,3,4,7,8,9,10,11,11a-decahydropyrazino[1,2-a]azocine-4-carboxamide family
No. of Seeds 7 No. of Other Members 18
Family Centroid CFAMM00398255 Functional Category Bioactive
Superfamily Caspase-8 and Caspase-1 Binder Superfamily
Class Class 2026

Cousin Family NamesSeedsMembers
Penicillin binding protein inhibitor β-lactam aminopenicillin ... 3 1
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Integrin alpha-V and Integrin beta-3 Inhibitor Cyclo-[-arg-gly... 5 38
Farnesyltransferase beta subunit, putative and Protein farnesy... 24 82
Plasmepsin-2 Inhibitor PS-222036 Family 12 134
Integrin beta-3 Inhibitor Sibrafiban Family 4 6
Integrin beta-3 Inhibitor L-709780 Family 9 10
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Inhibit... 5 23
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
Caspase-1 inhibitor AGN-PC-075AEI family 3 0
Caspase-1 and Caspase-8 inhibitor (4S,7S,11aS)-2-(benzenesulfo... 2 8
Caspase-1 and Caspase-8 inhibitor (4S,7S,11aS)-7-benzamido-N-[... 3 0
Caspase-1 and Caspase-8 inhibitor benzyl (4S,7S,9Z,11aS)-7-ben... 2 0
Caspase-1 and Caspase-8 inhibitor (4S,7S,9Z,11aS)-N-[(3S)-2-hy... 2 3
Caspase-1 and Caspase-8 inhibitor (4S,7S,9Z,11aS)-7-(1-benzoth... 2 3
Caspase-1 and Caspase-8 inhibitor N-[(6S)-3-(benzamidomethyl)-... 4 4
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 1 2
Caspase-1 and Caspase-8 inhibitor (4S,7S,11aS)-7-benzamido-4-N... 1 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 0


External ID

Functional Category

Molecule Name

CFAMM00398255 CHEMBL198743 Bioactive (4S,7S,11aS)-7-benzamido-N-[(3S)-2-hydroxy-5-oxooxolan-3-yl]-6-oxo-1,2,3,4,7,8,9,10,11,11a-decahydropyrazino[1,2-a]azocine-4-carboxamide
CFAMM00398248 CHEMBL198795 Bioactive (4S,7S,11aS)-7-benzamido-N-[(3S)-2-hydroxy-5-oxooxolan-3-yl]-2-methyl-6-oxo-3,4,7,8,9,10,11,11a-octahydro-1H-pyrazino[1,2-a]azocine-4-carboxamide
CFAMM00398260 CHEMBL200290 Bioactive (4S,7S,9Z,11aS)-N-[(3S)-2-hydroxy-5-oxooxolan-3-yl]-7-(naphthalene-2-carbonylamino)-6-oxo-3,4,7,8,11,11a-hexahydro-1H-[1,4]oxazino[4,3-a]azocine-4-carboxamide
CFAMM00398247 CHEMBL197127 Bioactive (4S,7S,11aS)-7-benzamido-2-benzoyl-N-[(3S)-2-hydroxy-5-oxooxolan-3-yl]-6-oxo-3,4,7,8,9,10,11,11a-octahydro-1H-pyrazino[1,2-a]azocine-4-carboxamide
CFAMM00398251 CHEMBL373028 Bioactive (4S,7S,11aS)-2-acetyl-7-benzamido-N-[(3S)-2-hydroxy-5-oxooxolan-3-yl]-6-oxo-3,4,7,8,9,10,11,11a-octahydro-1H-pyrazino[1,2-a]azocine-4-carboxamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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