CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9846
Family Name Vascular endothelial growth factor receptor 2 and Platelet-derived growth factor receptor beta ligand CHEMBL1978166 family
No. of Seeds 3 No. of Other Members 3
Family Centroid CFAMM00168958 Functional Category Bioactive
Superfamily Vascular endothelial growth factor receptor 2 Ligand 3-(4-aminophenyl)thieno[3,2-c]pyridin-4-amine Superfamily
Class Class 1151

Cousin Family NamesSeedsMembers
Aurora kinase B and Aurora kinase C Inhibitor SNS-314 Family 2 75
Aurora kinase B and Aurora kinase A Inhibitor CYC116 Family 16 135
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 8 53
Aurora kinase A Inhibitor ABT-348 Family 20 49
5-hydroxytryptamine receptor Ligand Sl65.0472 Family 2 16
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(thiophen... 9 66
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 6 64
Vascular endothelial growth factor receptor 2 Ligand 3-(4-amin... 2 5
Cyclin-dependent kinase 5 Inhibitor 1-phenyl-3-(2-(pyridin-4-y... 3 53
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-ethy... 2 2
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 22
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 13
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07ZBLC fa... 3 8
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 8 6
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(4-acet... 4 12
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 12 85
Prothrombin and Histone-lysine N-methyltransferase 2A inhibito... 1 7
Vascular endothelial growth factor receptor 2 and Mast/stem ce... 10 27
Serine/threonine-protein kinase Chk1 inhibitor SureCN3070314 f... 16 32
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 8 1
DNA-(apurinic or apyrimidinic site) lyase and Neuropeptide S r... 1 4
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Adenosine kinase inhibitor SureCN8183719 family 2 3
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 2 18
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 2 2
Mitogen-activated protein kinase 14 inhibitor N-[4-[2-ETHYL-4-... 4 5
Vascular endothelial growth factor receptor 1 and Vascular end... 4 0
Vascular endothelial growth factor receptor 1 and Receptor-typ... 1 0
Cell division cycle 7-related protein kinase and Protein DBF4 ... 2 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 12 7
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 1
Vascular endothelial growth factor receptor 2 and Vascular end... 4 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 1
Serine/threonine-protein kinase SMG1 and Serine/threonine-prot... 10 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 2
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 5 0
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 2 1
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 1 0
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
Protein-cysteine N-palmitoyltransferase porcupine inhibitor 2-... 5 2
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 3 6
Transient receptor potential cation channel subfamily V member... 1 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 1 5
Prostaglandin G/H synthase 2 inhibitor 4-N,4-N-diethyl-2-(4-me... 5 1
Epidermal growth factor receptor and Vascular endothelial grow... 2 1
Epidermal growth factor receptor and Vascular endothelial grow... 14 19
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Vascular endothelial growth factor receptor 2 ligand Thienopyr... 2 2
Transient receptor potential cation channel subfamily V member... 1 0
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor AGN-P... 1 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 5 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 1 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 5 1
Epidermal growth factor receptor ligand AGN-PC-00RWKI family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00398335 CHEMBL231127 Bioactive AGN-PC-008YSF

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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