CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9854
Family Name Adenosine receptor A2b and Adenosine receptor A3 ligand 3-[5-(2-methylimidazol-1-yl)-2-(pyrazin-2-ylamino)-1,3-thiazol-4-yl]benzonitrile family
No. of Seeds 4 No. of Other Members 2
Family Centroid CFAMM00159808 Functional Category Bioactive
Superfamily and Adenosine receptor A2b Binder Superfamily
Class Class 3914

Cousin Family NamesSeedsMembers
Aurora kinase B and Aurora kinase C Inhibitor SNS-314 Family 2 75
Aurora kinase B and Aurora kinase A Inhibitor CYC116 Family 16 135
Hepatocyte growth factor receptor Ligand SGX523 Family 1 15
Cytochrome P450 26A1 Inhibitor Rambazole Family 7 77
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
Steroid 17-alpha-hydroxylase/17,20 lyase Inhibitor 1-(1-(4-thi... 3 36
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 4 22
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 1 9
Mitogen-activated protein kinase 14 Inhibitor 9-benzyl-6-pheny... 5 33
TGF-beta receptor type-1 Ligand 4-pyridin-2-yl-5-quinolin-4-yl... 4 23
Mitogen-activated protein kinase 14 Inhibitor 4-(2-ethyl-4-m-t... 14 41
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 6 64
C-C chemokine receptor type 4 Ligand N-(4-tert-butylthiazol-2-... 3 9
Cyclin-dependent kinase 5 Inhibitor 1-phenyl-3-(2-(pyridin-4-y... 3 53
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 4 23
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-chlo... 11 20
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
Hepatocyte growth factor receptor Ligand 3-(phenylsulfonyl)-1h... 17 59
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07ZBLC fa... 3 8
Potassium voltage-gated channel subfamily H member 2 and Neuro... 2 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 4
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(4-acet... 4 12
Tyrosine-protein kinase JAK2 and Potassium voltage-gated chann... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-07ZDR2 f... 7 33
Neuropeptide Y receptor type 5 ligand N-[[(1S,5R)-3-(1-phenyle... 5 1
Neuropeptide Y receptor type 5 ligand 2-phenyl-1-[(1R,5S)-6-[[... 9 11
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 5
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZXHN fa... 2 4
5-hydroxytryptamine receptor 6 ligand 6-chloro-5-[1-(1-methylp... 9 0
Mitogen-activated protein kinase 14 and LIM domain kinase 1 in... 4 19
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 8
DNA-(apurinic or apyrimidinic site) lyase and Neuropeptide S r... 1 4
Inosine-5'-monophosphate dehydrogenase and Nuclear receptor RO... 2 9
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Platelet-activating factor receptor ligand Foropafant family 2 0
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 27
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 2 18
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 2 0
Fatty-acid amide hydrolase 1 inhibitor 5-[5-(4-chlorophenyl)su... 2 4
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
Somatostatin receptor type 5 and Somatostatin receptor type 2 ... 6 3
Mitogen-activated protein kinase 14 inhibitor N-[4-[2-ETHYL-4-... 4 5
TGF-beta receptor type-1 ligand 6-[(5E)-5-(4-methyl-3H-1,3-thi... 22 9
Serine/threonine-protein kinase Chk1 inhibitor 5-[5-(1-methylp... 3 2
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 6 4
D(3) dopamine receptor and D(2) dopamine receptor ligand 6-N-[... 3 0
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(1,4-di... 3 3
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 7
Orexin receptor type 2 and Orexin receptor type 1 ligand 6-ami... 3 1
Glucocorticoid receptor ligand 3-[1-(4-fluorophenyl)imidazo[1,... 5 3
Tyrosine-protein kinase ITK/TSK and Tyrosine-protein kinase Lc... 2 2
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 3 6
Trans-2-enoyl-ACP reductase II inhibitor AGN-PC-01LWZK family 3 0
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 1
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Epidermal growth factor receptor and Vascular endothelial grow... 3 1
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 0
Mitogen-activated protein kinase 14 inhibitor 303163-37-3 family 1 2
5-hydroxytryptamine receptor 6 ligand 8-(1-pyrrolidin-3-ylpyrr... 1 0
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 4 5
Alpha-1A adrenergic receptor and Alpha-2A adrenergic receptor ... 1 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 4 1
Transient receptor potential cation channel subfamily V member... 1 0
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor AGN-P... 1 0
Prostaglandin G/H synthase 2 inhibitor AGN-PC-00FW8Y family 1 1
Cytochrome P450 11B1, mitochondrial and Cytochrome P450 11B2, ... 1 1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 5 1
Corticotropin-releasing factor receptor 1 ligand 2-[1-[1-[4-ni... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27746 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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