CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9875
Family Name Proto-oncogene tyrosine-protein kinase Src and Vascular endothelial growth factor receptor 2 ligand AGN-PC-075Y9T family
No. of Seeds 7 No. of Other Members 3
Family Centroid CFAMM00145228 Functional Category Bioactive with Natural Product
Superfamily Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-protein kinase Src Inhibitor AZD0530 Superfamily
Class Class 386

Cousin Family NamesSeedsMembers
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Tyrosine-protein kinase SYK Inhibitor R788 Family 3 7
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 25 40
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
AP26113 family 16 90
SB1518 family 7 103
Varlitinib family 2 8
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
Proto-oncogene tyrosine-protein kinase Src inhibitor N-(2,4-di... 3 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
Tyrosine-protein kinase Lck inhibitor AGN-PC-073GX8 family 12 1
Epidermal growth factor receptor ligand N-[4-(3-chloro-4-fluor... 6 47
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 10
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 6 12
Epidermal growth factor receptor and Receptor tyrosine-protein... 6 9
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Ephrin type-B receptor 4 ligand SureCN5131922 family 4 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 10 4
ALK tyrosine kinase receptor and Insulin-like growth factor 1 ... 1 4
Epidermal growth factor receptor ligand N-[3-[7-[2-methoxy-4-(... 9 3
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 0
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 7 16
Epidermal growth factor receptor ligand SureCN4454332 family 18 5
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 14 2
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4463897 f... 3 2
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 9 2
Receptor tyrosine-protein kinase erbB-2 ligand SureCN3374869 f... 4 8
Transient receptor potential cation channel subfamily V member... 2 0
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Glucagon receptor ligand SureCN2647807 family 3 7
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 1 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
Epidermal growth factor receptor ligand Pyrido[3,4-d]pyrimidin... 3 1
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 1
TGF-beta receptor type-1 ligand SureCN373216 family 3 14
1-acyl-sn-glycerol-3-phosphate acyltransferase beta inhibitor ... 1 2
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 3
Corticotropin-releasing factor receptor 1 ligand N-(dicyclopro... 3 35


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00398456 CHEMBL199110 Bioactive AGN-PC-009WIX
CFAMM00398454 CHEMBL383593 Bioactive AGN-PC-075YAN
CFAMM00398453 CHEMBL198701 Bioactive AGN-PC-00CIZR

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26400 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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