CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9882
Family Name Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-aminobutyric acid receptor subunit beta-1 ligand 8-chloro-2-(4-methoxyphenyl)-5H-[1,2,4]triazolo[1,5-a]quinoxalin-4-one family
No. of Seeds 4 No. of Other Members 4
Family Centroid CFAMM00398486 Functional Category Bioactive
Superfamily Gamma-aminobutyric acid receptor subunit beta-1 and Gamma-aminobutyric acid receptor subunit alpha-1 Binder Superfamily
Class Class 3394

Cousin Family NamesSeedsMembers
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
Ibrutinib family 2 27
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Tyrosine kinase Inhibitor PKI166 Family 17 198
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Corticotropin-releasing factor receptor 1 Ligand BMS-561388 Fa... 10 16
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... 1 11
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 11
Epidermal growth factor receptor and Tyrosine-protein kinase A... 4 3
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Su... 2 16
Epidermal growth factor receptor and Cyclin-dependent kinase 1... 3 4
Translocator protein inhibitor AGN-PC-080ILF family 9 3
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 52 12
cGMP-specific 3',5'-cyclic phosphodiesterase and Calcium/calmo... 12 1
DNA-(apurinic or apyrimidinic site) lyase and Ras-related prot... 1 5
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 4
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 6
Tyrosine-protein kinase JAK2 inhibitor 5-(3-methoxyphenyl)-N-[... 2 11
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 5
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 7 6
Neuropeptide Y receptor type 1 ligand CP-671906 family 10 0
Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... 5 5
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
Hepatocyte growth factor receptor ligand 4-[(6-phenyl-[1,2,4]t... 3 6
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 7 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2
Mitogen-activated protein kinase 14 inhibitor AGN-PC-075YQ1 fa... 4 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 0
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 7 1
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alph... 2 0
Estrogen receptor and Estrogen receptor beta ligand 4-[3-[4-(2... 1 0
Histamine H4 receptor ligand AGN-PC-00FEQJ family 2 3
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
cGMP-dependent 3',5'-cyclic phosphodiesterase inhibitor SureCN... 4 0
Collagenase 3 inhibitor 5-[4-[4-(1H-benzimidazol-2-yl)phenoxy]... 3 0
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 1
Glucagon receptor ligand SureCN2647807 family 3 7
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 2
Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... 4 3
Adenosine receptor A2a ligand AGN-PC-077RYH family 16 5
Corticotropin-releasing factor receptor 1 ligand AGN-PC-068CCI... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Aurora kinase A and Glycogen synthase kinase-3 beta inhibitor ... 1 2
Adenosine receptor A2b and Gamma-aminobutyric acid receptor su... 1 1
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0
Potassium voltage-gated channel subfamily H member 2 and Melan... 2 1
Lysosomal Pro-X carboxypeptidase inhibitor 4-[6-[(2S)-2-(5,6-d... 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00398486 CHEMBL98678 Bioactive 8-chloro-2-(4-methoxyphenyl)-5H-[1,2,4]triazolo[1,5-a]quinoxalin-4-one
CFAMM00398484 CHEMBL99178 Bioactive 2-(4-methoxyphenyl)-5H-[1,2,4]triazolo[1,5-a]quinoxalin-4-one
CFAMM00398490 CHEMBL197376 Bioactive 2-(4-methoxyphenyl)-8-methyl-5H-[1,2,4]triazolo[1,5-a]quinoxalin-4-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27668 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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