CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM989
Family Name Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-N-(2-adamantyl)-1-pyridin-2-ylpyrrolidine-2-carboxamide family
No. of Seeds 1 No. of Other Members 0
Family Centroid CFAMM00139901 Functional Category Bioactive
Superfamily Corticosteroid 11-beta-dehydrogenase isozyme 1 and Lethal factor Binder Superfamily
Class Class 960

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Transient receptor potential cation channel subfamily V member... 16 295
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Dipeptidyl peptidase 4 Inhibitor Nvp-dpp728 Family 11 42
XL-888 family 16 85
Class II cytokine receptor Ligand IL-10 Family 7 45
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-(9-oxo-9h-fluoren-4-yl)-... 3 5
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
DNA-dependent protein kinase catalytic subunit Inhibitor 2-mor... 2 6
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Calcitonin gene-related peptide type 1 receptor Ligand Isomer ... 30 31
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Metabotropic glutamate receptor 5 Ligand 3-cyano-5-fluoro-n-(p... 2 9
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Histamine H3 receptor ligand 1-[1-[1-[(2-aminopyridin-4-yl)met... 16 9
Prothrombin and Cationic trypsin inhibitor tert-butyl N-[(2R)-... 4 3
Prothrombin inhibitor (2S)-N-[(6-carbamimidoylpyridin-3-yl)met... 2 14
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 1
Dipeptidyl peptidase 4 inhibitor SureCN3389584 family 2 2
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 3 1
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 8-[(3-meth... 3 1
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-isoquinolin-1-y... 3 2
Substance-P receptor ligand Netupitant family 5 2
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 7 6
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor SureC... 6 0
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 2
Integrin alpha-V and Integrin beta-6 inhibitor 3-[[2-[4-[(4-me... 4 3
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Corticoster... 2 0
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 7 0
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 2 0
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
Platelet-activating factor receptor ligand SureCN9853140 family 3 3
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 1 0
Transient receptor potential cation channel subfamily V member... 1 0
Integrin beta-3 and Integrin alpha-IIb inhibitor (3S)-3-[[2-[(... 3 1
Metabotropic glutamate receptor 1 ligand [(3aS,6aR)-2-(6-fluor... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27525 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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