CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9919
Family Name Neuronal acetylcholine receptor subunit beta-2 and Neuronal acetylcholine receptor subunit alpha-4 ligand CHEMBL199096 family
No. of Seeds 10 No. of Other Members 6
Family Centroid CFAMM00398662 Functional Category Bioactive
Superfamily Progesterone receptor and D(2) dopamine receptor Binder Superfamily 2
Class Class 667

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
5-hydroxytryptamine receptor 1D Ligand Rizatriptan Family 7 460
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
Benzodiazepine receptor Ligand Midazolam Family 5 160
Toll-like receptor 7 Ligand Imiquimod Family 3 237
Histamine H1 receptor Ligand Emedastine Family 5 115
Histamine H1 receptor Ligand Mizolastine Family 14 603
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
HCV NS4B protein Inhibitor Clemizole Family 2 43
JNJ-39439335 family 5 11
BIBT986 family 7 96
Amg 423 family 7 47
SB989 family 17 91
GDC-0349 family 44 77
PF-4217903 family 14 65
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
Tryptase Inhibitor Babim Family 12 90
Histamine H3 receptor and Histamine H4 receptor Ligand Clobenp... 31 38
D(4) dopamine receptor Ligand L-745,870 Family 30 205
5-hydroxytryptamine receptor 2B Ligand MT-500 Family 8 39
Histamine H3 receptor Ligand SCH79687 Family 11 29
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
Vascular endothelial growth factor receptor 2 Ligand 6-(1h-ben... 2 5
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Peptide deformylase, mitochondrial Inhibitor 5-phenethyl-quina... 5 14
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 14 13
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Methionine aminopeptidase 2 Inhibitor 2-(pyridin-2-yl)-1h-benz... 6 19
Aromatase and Thromboxane-A synthase Inhibitor 6-(1h-imidazol-... 3 8
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Telomerase reverse transcriptase Inhibitor HOE-33258 Family 10 33
Adenosine receptor A1 Ligand Phenyl-(9-phenyl-9h-purin-6-yl)-a... 7 12
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-aminobenzyl... 3 6
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Adenosine receptor A3 Ligand 2-(4-nitro-1h-benzo[d]imidazol-2-... 2 12
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Cathepsin K Inhibitor 4-phenyl-6-propylpyrimidine-2-carbonitri... 6 10
Indoleamine 2,3-dioxygenase 1 Inhibitor 3-(4h-imidazol-4-yl)be... 6 3
Aromatase Inhibitor NSC-356781 Family 3 10
Aromatase and Cytochrome P450 26A1 Inhibitor Liarozole Family 4 1
Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimid... 5 37
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Farnesyl pyrophosphate synthase Inhibitor [2-(benzoimidazol-1-... 2 16
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-bromobenzyl... 3 0
Histamine H3 receptor Ligand 4-(2-(phenylamino)ethyl)-1h-imida... 5 16
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-(2-(4-... 25 10
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 8
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 2 3
Acetylcholinesterase inhibitor SureCN251059 family 2 16
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
Corticotropin-releasing factor receptor 1 ligand N-(cyclopropy... 2 10
Bombesin receptor subtype-3 ligand (2R)-1-[4-[2-[5-(2,2-dimeth... 1 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 28 9
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 3
Platelet-activating factor receptor ligand AGN-PC-0750SP family 4 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 4
Histamine H4 receptor ligand SureCN602132 family 1 8
Melanin-concentrating hormone receptor 1 and Potassium voltage... 8 27
Melanin-concentrating hormone receptor 1 ligand AGN-PC-088XRP ... 2 10
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
Neuropeptide Y receptor type 5 ligand 8-[6-(4-fluorophenyl)-1H... 2 1
C-C chemokine receptor type 5 ligand SureCN1573831 family 4 3
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-met... 13 8
Nociceptin receptor and Kappa-type opioid receptor ligand 1-[1... 4 4
Histamine H4 receptor ligand (2Z)-5-chloro-2-[(1-methylpiperid... 2 8
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 21 32
Transient receptor potential M8 protein ligand 2-[(E)-2-(oxan-... 5 3
Transient receptor potential cation channel subfamily M member... 9 0
Transient receptor potential M8 protein and Cytochrome P450 2C... 4 0
Nociceptin receptor and Kappa-type opioid receptor ligand AGN-... 5 2
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 9 10
Corticotropin-releasing factor receptor 1 ligand 9-(2-bromo-4-... 15 3
Corticotropin-releasing factor receptor 1 ligand SureCN6301726... 4 1
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
C-C chemokine receptor type 5 ligand methyl N-cyano-4-[2-[(1R,... 8 8
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 3
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 10 14
Progesterone receptor ligand AGN-PC-00B9AT family 4 4
Mitogen-activated protein kinase 14 inhibitor 6-[5-(2,4-difluo... 9 3
Histamine H4 receptor and Histamine H3 receptor ligand (E)-[(3... 4 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Histamine H1 receptor and Potassium voltage-gated channel subf... 1 2
Serine/threonine-protein kinase mTOR inhibitor 5-(2-amino-3H-b... 3 1
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Melanin-concentrating hormone receptor 1 ligand AGN-PC-00BSP9 ... 6 12
Neuropeptide Y receptor type 5 ligand 2-(3-phenylpiperidin-1-y... 6 2
Melanin-concentrating hormone receptor 1 ligand 3-[(1R,3R,6S)-... 2 4
Cdc2-related kinase inhibitor N-[6-(3,5-dimethylphenyl)-1-meth... 1 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 2 1
Mitogen-activated protein kinase 14 inhibitor 6-[2-(2,6-difluo... 3 0
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
Histamine H4 receptor and Histamine H3 receptor ligand 7-cyclo... 2 0
Melanin-concentrating hormone receptor 1 and Potassium voltage... 4 4
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Metabotropic glutamate receptor 2 ligand 8-(2,5-difluorophenyl... 6 2
Melanin-concentrating hormone receptor 1 ligand (2S)-2-[[(3R,4... 2 0
Melanin-concentrating hormone receptor 1 and Mu-type opioid re... 2 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 2
Dipeptidyl peptidase 4 inhibitor 7-(aminomethyl)-6-(2-chloroph... 2 5
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Type-1 angiotensin II receptor ligand SureCN7390271 family 2 1
C-C chemokine receptor type 5 ligand 1-[4-(3-chlorophenyl)-4-[... 3 1
Gonadotropin-releasing hormone receptor ligand SureCN3275214 f... 5 0
Type-1 angiotensin II receptor ligand AGN-PC-04X8EF family 1 1
Proto-oncogene tyrosine-protein kinase Src and Tyrosine-protei... 3 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 0
Gonadotropin-releasing hormone receptor ligand 4-[[4-[2-(4-ter... 3 3
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Nociceptin receptor and Mu-type opioid receptor ligand 2-(3-ch... 2 0
Pteridine reductase, putative inhibitor 1-[(3,4-dichlorophenyl... 2 1
D(2) dopamine receptor ligand 4-bromo-6-[2-[4-[3-(trifluoromet... 1 2
B1 bradykinin receptor ligand AGN-PC-077LWO family 2 0
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0
5-hydroxytryptamine receptor 2B ligand SureCN1299053 family 1 1
Sodium/hydrogen exchanger 1 inhibitor 2-[(E)-[2-(1H-benzimidaz... 3 14
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 1 0
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Small conductance calcium-activated potassium channel protein ... 1 0
D(2) dopamine receptor and D(4) dopamine receptor ligand 3-[1-... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00398655 CHEMBL199046 Bioactive CHEMBL199046
CFAMM00398662 CHEMBL199096 Bioactive CHEMBL199096
CFAMM00398654 CHEMBL198333 Bioactive CHEMBL198333
CFAMM00398661 CHEMBL199097 Bioactive SureCN5820941
CFAMM00398660 CHEMBL197891 Bioactive CHEMBL197891
CFAMM00398659 CHEMBL198444 Bioactive CHEMBL198444
CFAMM00398651 CHEMBL198032 Bioactive CHEMBL198032
CFAMM00398658 CHEMBL382313 Bioactive CHEMBL382313

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26384 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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