CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9927
Family Name Cathepsin L1 and Cathepsin S inhibitor arylaminoethyl amide, 5h family
No. of Seeds 4 No. of Other Members 5
Family Centroid CFAMM00184943 Functional Category Bioactive
Superfamily Cathepsin K and Cathepsin L1 Binder Superfamily 2
Class Class 2417

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Tubulin Inhibitor WR85915 Family 3 15
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Histone deacetylase 2 Inhibitor N-(4-amino-3'-methoxybiphenyl-... 3 49
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Sodium channel protein type 10 subunit alpha and Sodium channe... 2 13
Coagulation factor X Inhibitor BMS-269223 Family 15 58
Proto-oncogene tyrosine-protein kinase receptor Ret Ligand (z)... 1 60
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
D(2) dopamine receptor Ligand Epidepride Family 31 66
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEH3 family 3 16
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 8... 4 15
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
D(3) dopamine receptor and D(1A) dopamine receptor ligand N-[(... 6 14
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 2
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 7 9
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 11 9
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
Thyroid hormone receptor beta ligand SureCN8800248 family 3 10
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 3
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Cathepsin S and Cathepsin K inhibitor arylaminoethyl amide, 7 ... 2 0
Growth hormone secretagogue receptor type 1 ligand (2R)-N-(1-b... 11 4
Microsomal triglyceride transfer protein large subunit inhibit... 3 0
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (2R... 8 9
Receptor-type tyrosine-protein kinase FLT3 ligand (3Z)-5-chlor... 1 4
Bifunctional epoxide hydrolase 2 inhibitor 3-[4-[[4-(trifluoro... 5 22
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 6 11
Bifunctional epoxide hydrolase 2 and RAF proto-oncogene serine... 4 10
Neuropeptide Y receptor type 5 ligand 1-[1-(4-fluorophenyl)pro... 2 8
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6627432 f... 6 1
Acyl-CoA desaturase 1 inhibitor AGN-PC-077KJY family 5 4
Leukotriene A-4 hydrolase inhibitor SureCN5313952 family 4 1
Growth hormone secretagogue receptor type 1 ligand N-[4-[(2S)-... 1 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(2-chlo... 2 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(2-chlo... 2 4
Histone deacetylase 1 and Histone deacetylase 2 inhibitor Sure... 2 0
Thioredoxin glutathione reductase and Microtubule-associated p... 1 2
Sodium channel protein type 1 subunit alpha and Sodium channel... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00398695 CHEMBL198438 Bioactive arylaminoethyl amide, 10

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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