CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9931
Family Name RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridin-3-yl]-3-phenyl-1,3-dihydroindol-2-one family
No. of Seeds 14 No. of Other Members 2
Family Centroid CFAMM00398713 Functional Category Bioactive
Superfamily RAC-alpha serine/threonine-protein kinase and Nuclear receptor ROR-gamma Binder Superfamily
Class Class 3208

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Cyclooxygenase Inhibitor Indomethacin Family 6 271
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
DNA Binder Elliptinium Acetate Family 11 116
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Indeglitazar family 3 39
PF-02545920 family 16 140
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 2-benzyl-6-... 9 80
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
D(2) dopamine receptor Ligand SLV-314 Family 19 69
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 14
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 7 11
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Disintegrin and metalloproteinase domain-containing protein 17... 2 8
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 4
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 20
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 6
Neutrophil collagenase and Stromelysin-3 inhibitor AC1MORIH fa... 7 9
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 3 5
Vascular endothelial growth factor receptor 2 ligand indolyl q... 2 1
Acetylcholinesterase and Muscarinic acetylcholine receptor M2 ... 2 7
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 5 2
Pol polyprotein and Cytochrome P450 3A4 inhibitor P3 arylpyrro... 19 1
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 2 15
Disintegrin and metalloproteinase domain-containing protein 17... 2 1
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 8 3
Cathepsin S and Cathepsin K inhibitor N-[(2S)-3-(1-methylcyclo... 2 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 6 5
Protein kinase C alpha type and Protein kinase C delta type in... 4 37
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 11 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 4 0
Acetylcholinesterase inhibitor CHEMBL1651140 family 4 4
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 2 6
Gonadotropin-releasing hormone receptor and Cytochrome P450 3A... 3 0
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 9 7
Somatostatin receptor type 2 ligand SureCN4313450 family 2 25
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 7 1
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801290 ... 3 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 0
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 2 11
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 3 0
Mu-type opioid receptor ligand AGN-PC-075GBK family 4 4
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
Integrin alpha-V and Integrin beta-5 inhibitor SureCN2489170 f... 8 0
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Serine/threonine-protein kinase B-raf inhibitor pyrrole-based ... 2 0
RAC-alpha serine/threonine-protein kinase inhibitor N-[(2S)-1-... 2 1
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Beta-3 adrenergic receptor ligand 6-[4-[2-[[(2S)-3-[(3,3-dimet... 6 7
Vascular endothelial growth factor receptor 2 and Vascular end... 2 52
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 3 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Plasmepsin-2 and Cathepsin D inhibitor 4-[4-[[(2S,3S)-1-[[(3S,... 3 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
RAC-alpha serine/threonine-protein kinase inhibitor 6-[5-[(2S)... 1 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 2 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 3 1
Neuronal acetylcholine receptor subunit alpha-7 ligand 5-[6-[[... 1 0
Mu-type opioid receptor and Mu-type opioid receptor ligand (3S... 6 2
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
Casein kinase I isoform gamma-2 and Casein kinase I isoform de... 5 2
Acetylcholinesterase and Cholinesterase inhibitor N-[5-[(6-chl... 4 2
Acetylcholinesterase and Cholinesterase inhibitor CHEMBL237591... 1 1
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Serine/threonine-protein kinase PLK4 inhibitor (3E)-5-methoxy-... 4 0
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Substance-P receptor ligand N-[(2R)-1-[acetyl-[(2-chlorophenyl... 2 2
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Substance-P receptor ligand SureCN2139814 family 7 7
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 6 8
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
Gonadotropin-releasing hormone receptor ligand methyl 4-[2-[[(... 2 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 1
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 3 0
RAC-alpha serine/threonine-protein kinase inhibitor Isoquinoli... 1 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
Substance-P receptor ligand AGN-PC-00FIT5 family 3 11
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Melanocortin receptor 4 and Melanocyte-stimulating hormone rec... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
Protein kinase C theta type and Protein kinase C delta type in... 10 7
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
B2 bradykinin receptor ligand 1-N,3-N-dimethyl-4-[methyl-[2-[[... 4 1
B2 bradykinin receptor and Cytochrome P450 3A4 ligand SureCN15... 4 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 0
Protein kinase C theta type and Protein kinase C delta type in... 5 4
Bombesin receptor subtype-3 ligand 2-[[(E)-furan-2-ylmethylide... 2 4
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 15 1
Sodium-dependent serotonin transporter inhibitor SureCN5477150... 4 1
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN8798759 f... 1 0
Amino Acids and Derivatives Metabolite Flazine Family 3 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00398717 CHEMBL379963 Bioactive 5-[5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridin-3-yl]-3-[2-methyl-1-(1-methylpyrrol-2-yl)propan-2-yl]-1,3-dihydroindol-2-one
CFAMM00398710 CHEMBL583705 Bioactive 5-[5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridin-3-yl]-3-(1-methylpyrrol-2-yl)-1,3-dihydroindol-2-one
CFAMM00398723 CHEMBL210034 Bioactive 5-[5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridin-3-yl]-3-(2-methyl-1-phenylpropan-2-yl)-1,3-dihydroindol-2-one
CFAMM00398716 CHEMBL377603 Bioactive 5-[5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridin-3-yl]-3-[2-methyl-1-(1H-pyrrol-2-yl)propan-2-yl]-1,3-dihydroindol-2-one
CFAMM00398709 CHEMBL212067 Bioactive 5-[5-[(2S)-2-[(3,3-difluoro-2-oxo-1H-indol-5-yl)amino]-3-(1H-indol-3-yl)propoxy]pyridin-3-yl]-3,3-difluoro-1H-indol-2-one
CFAMM00398722 CHEMBL388311 Bioactive oxindole-pyridine, 35
CFAMM00398715 CHEMBL212566 Bioactive 5-[5-[(2S)-3-(1H-indol-3-yl)-2-[(2-oxo-1,3-dihydroindol-5-yl)amino]propoxy]pyridin-3-yl]-1,3-dihydroindol-2-one
CFAMM00398714 CHEMBL577377 Bioactive oxindole pyridine, 9t
CFAMM00398720 CHEMBL574269 Bioactive 5-[5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridin-3-yl]-3-cyclopropyl-1,3-dihydroindol-2-one
CFAMM00398713 CHEMBL577379 Bioactive 5-[5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridin-3-yl]-3-phenyl-1,3-dihydroindol-2-one
CFAMM00398712 CHEMBL576348 Bioactive 5-[5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridin-3-yl]-3-(1H-pyrrol-2-yl)-1,3-dihydroindol-2-one
CFAMM00398718 CHEMBL208761 Bioactive 5-[5-[(2S)-3-(1H-indol-3-yl)-2-[(3-methyl-2-oxo-1,3-dihydroindol-5-yl)amino]propoxy]pyridin-3-yl]-3-methyl-1,3-dihydroindol-2-one
CFAMM00398724 CHEMBL210940 Bioactive 5-[5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridin-3-yl]-3-[2-methyl-1-(1H-pyrrol-3-yl)propan-2-yl]-1,3-dihydroindol-2-one
CFAMM00398711 CHEMBL378827 Bioactive 5-[5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridin-3-yl]-3-(1-cyclopropyl-2-methylpropan-2-yl)-1,3-dihydroindol-2-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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