CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM994
Family Name Hepatocyte growth factor receptor and Receptor-type tyrosine-protein kinase FLT3 ligand SureCN4482804 family
No. of Seeds 12 No. of Other Members 26
Family Centroid CFAMM00171697 Functional Category Bioactive
Superfamily Serine/threonine-protein kinase mTOR and Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Binder Superfamily 2
Class Class 850

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase B-raf inhibitor diaryl urea an... 12 93
Transient receptor potential cation channel subfamily V member... 42 32
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
DCC-2036 family 2 5
Smoothened homolog Inhibitor LDE225 Family 3 76
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
E7050 family 2 13
Multiple kinase Inhibitor MGCD265 Family 19 71
MK-6096 family 3 69
Glucokinase Inhibitor GKA1 Family 2 67
Tyrosine kinase Inhibitor PKI166 Family 17 198
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
Platelet-derived growth factor receptor alpha and Fibroblast g... 3 47
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Hepatocyte growth factor receptor Ligand BMS-777607 Family 10 1
Potassium voltage-gated channel subfamily H member 2 Ligand Be... 22 56
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Reverse transcriptase/RNaseH inhibitor AC1LALKM family 2 19
Hepatocyte growth factor receptor ligand SureCN4492034 family 2 2
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
Aurora kinase A inhibitor SureCN761545 family 2 2
Aurora kinase A inhibitor SureCN761045 family 2 0
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Bifunctional epoxide hydrolase 2 inhibitor SureCN3216677 family 4 9
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Inositol monophosphatase 1 inhibitor CHEMBL1588383 family 1 6
Histamine H3 receptor ligand SureCN7251693 family 3 1
Calcium/calmodulin-dependent protein kinase kinase 2 and Focal... 3 17
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 4
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 3 1
Fatty-acid amide hydrolase 1 inhibitor 2-(1,3-dihydroisoindol-... 2 3
Renin inhibitor [2-(5-fluoro-2-methylphenoxy)-5-hydroxy-1-phen... 2 0
Renin inhibitor [2-(2,6-dimethylphenoxy)-6-methoxy-1-phenylpyr... 1 0
Renin inhibitor [2-(3-fluoro-2,6-dimethylphenoxy)-1-phenylpyrr... 5 12
Acyl-CoA desaturase 1 and Acyl-CoA desaturase inhibitor 2-[4-[... 2 6
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 4 9
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Insulin-like growth factor 1 receptor ligand 3-[[2-[2-methoxy-... 2 0
Insulin-like growth factor 1 receptor ligand GSK1220512A family 20 15
Insulin-like growth factor 1 receptor ligand 4-(2,3-dihydroind... 1 0
Adenosine receptor A2b ligand 2-[5-(2,6-dioxo-1,3-dipropyl-7H-... 1 0
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Histamine H3 receptor ligand AGN-PC-075YXY family 1 4
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 8 6
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Growth hormone secretagogue receptor type 1 ligand SureCN36800... 14 42
ALK tyrosine kinase receptor ligand 4-fluoro-N-[1-[4-(propan-2... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 3 5
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4463897 f... 3 2
Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... 2 0
Motilin receptor ligand SureCN2765637 family 1 1
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Angiopoietin-1 receptor ligand SureCN1939461 family 1 0
Focal adhesion kinase 1 inhibitor 2-[[2-(2-methoxy-4-morpholin... 2 1
Bifunctional epoxide hydrolase 2 inhibitor 8-(1H-benzimidazole... 1 0
Vascular endothelial growth factor receptor 2 and Angiopoietin... 3 3
Angiopoietin-1 receptor and Vascular endothelial growth factor... 2 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Mast/stem cell growth factor receptor Kit and Serine/threonine... 11 29
Collagenase 3 inhibitor 1-[6-[4-(1H-benzimidazol-2-yl)phenoxy]... 3 0
Adenosine receptor A2a and Adenosine receptor A1 ligand 2-(3-c... 3 3
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Cyclin-dependent kinase 1 inhibitor AGN-PC-075VQQ family 2 0
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 0
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Cyclin-dependent kinase 1 and Receptor tyrosine-protein kinase... 2 3
Cholecystokinin receptor type A ligand AGN-PC-077L8J family 22 2
Insulin-like growth factor 1 receptor ligand SureCN310120 family 10 0
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 15 1
Hepatocyte growth factor receptor ligand 4-pyridone analogue, ... 8 0
Insulin-like growth factor 1 receptor ligand GSK2110236A family 5 0
Insulin-like growth factor 1 receptor ligand AGN-PC-077MU8 family 2 0
Insulin-like growth factor 1 receptor ligand AGN-PC-050GPS family 7 0
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 6 0
Transient receptor potential cation channel subfamily V member... 2 0
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 5 0
Alpha-2C adrenergic receptor and Alpha-2B adrenergic receptor ... 2 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 0
Hepatocyte growth factor receptor ligand AGN-PC-077PZW family 1 0
Epidermal growth factor receptor ligand Pyrido[3,4-d]pyrimidin... 3 1
Insulin-like growth factor 1 receptor ligand AGN-PC-07C5TC family 2 4
LIM domain kinase 2 and LIM domain kinase 1 inhibitor SureCN36... 1 1
Mitogen-activated protein kinase 14 inhibitor AGN-PC-015IFD fa... 2 0
Mitogen-activated protein kinase 14 inhibitor SureCN4838024 fa... 1 0
Vascular endothelial growth factor receptor 2 ligand SureCN472... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00318276 CHEMBL1097543 Bioactive SureCN4481602
CFAMM00318254 CHEMBL454101 Bioactive 2-pyridone analogue, 18
CFAMM00318243 CHEMBL459875 Bioactive AGN-PC-04TKP7
CFAMM00318274 CHEMBL1097868 Bioactive SureCN4484473
CFAMM00318266 CHEMBL453850 Bioactive 2-pyridone analogue, 17
CFAMM00318242 CHEMBL459876 Bioactive AGN-PC-04TKP8
CFAMM00318258 CHEMBL1099174 Bioactive SureCN4478577
CFAMM00318251 CHEMBL451809 Bioactive 2-pyridone analogue, 13
CFAMM00318257 CHEMBL524364 Bioactive SureCN4819472
CFAMM00318256 CHEMBL525260 Bioactive AGN-PC-035JCZ

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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