CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9950
Family Name Cathepsin S and Cathepsin K inhibitor arylaminoethyl amide, 7 family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00213991 Functional Category Bioactive
Superfamily Cathepsin S and Cathepsin K Binder Superfamily
Class Class 2520

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Sodium channel protein type 10 subunit alpha Ligand A-803467 F... 2 81
Histamine H3 receptor Ligand A-317920 Family 9 240
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 4-(2... 4 31
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Melatonin receptor type 1A and Melatonin receptor type 1B Liga... 33 98
Leukotriene A-4 hydrolase Inhibitor N5-[4-(2-oxo-3-phenylpropo... 1 61
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Macrophage migration inhibitory factor Inhibitor Benzofuran-2-... 5 67
Sodium channel protein type 10 subunit alpha and Sodium channe... 2 13
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 2 17
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
Substance-K receptor ligand 5-chloro-N-[1-[[(2S)-5-[4-(oxan-4-... 2 4
Beta-secretase 1 inhibitor SureCN3599637 family 1 0
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 4
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 4 2
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 11 4
Sodium channel protein type 10 subunit alpha ligand AGN-PC-09M... 1 7
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 4 2
Prostaglandin E2 receptor EP4 subtype ligand SureCN5653729 family 3 2
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 3
MAP kinase-activated protein kinase 2 inhibitor 5-(4-cyanophen... 3 8
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Cathepsin L1 and Cathepsin S inhibitor arylaminoethyl amide, 5... 4 5
Growth hormone secretagogue receptor type 1 ligand (2R)-N-(1-b... 11 4
Translocator protein inhibitor N-[(2,5-dimethoxyphenyl)methyl]... 1 0
Histamine H3 receptor ligand SureCN5218144 family 4 6
Bifunctional epoxide hydrolase 2 inhibitor 3-[4-[[4-(trifluoro... 5 22
Bifunctional epoxide hydrolase 2 inhibitor 8-(2-methylfuran-3-... 2 1
Macrophage colony-stimulating factor 1 receptor ligand 5-cyano... 5 6
5-hydroxytryptamine receptor 1A ligand SureCN10513645 family 9 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Oxytocin receptor and Vasopressin V1a receptor ligand N-[[5-[4... 1 0
Mu-type opioid receptor ligand AGN-PC-00NCMO family 3 1
Glucagon receptor and Adenylate cyclase type 1 ligand AGN-PC-0... 3 1
Leukotriene A-4 hydrolase inhibitor SureCN5313952 family 4 1
ATP-sensitive inward rectifier potassium channel 11 ligand N-[... 1 0
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 1 0
Gonadotropin-releasing hormone receptor ligand N-[[4-[(diamino... 6 4
Sphingosine 1-phosphate receptor 4 ligand AGN-PC-079GSR family 11 7
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN8808982 f... 1 2
Ras-related protein Rab-9A and Niemann-Pick C1 protein inhibit... 1 4
Nuclear receptor ROR-gamma and Niemann-Pick C1 protein ligand ... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00398811 CHEMBL198450 Bioactive arylaminoethyl amide, 20

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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