CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9956
Family Name Caspase-1 and Caspase-8 inhibitor (4S,7S,11aS)-2-(benzenesulfonyl)-N-[(3S)-2-hydroxy-5-oxooxolan-3-yl]-7-(isoquinoline-1-carbonylamino)-6-oxo-3,4,7,8,9,10,11,11a-octahydro-1H-pyrazino[1,2-a]azocine-4-carboxamide family
No. of Seeds 3 No. of Other Members 0
Family Centroid CFAMM00251105 Functional Category Bioactive
Superfamily Caspase-3 and Caspase-1 Inhibitor Pralnacasan Superfamily
Class Class 137

Cousin Family NamesSeedsMembers
HIV protease Inhibitor Indinavir Family 36 211
HIV-1 protease Inhibitor Atazanavir Family 16 58
Caspase-3 and Caspase-1 Inhibitor Pralnacasan Family 6 8
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Renin inhibitor (2S,4S,5S)-6-cyclohexyl-4-hydroxy-5-[[(2S)-2-[... 3 0
Pol polyprotein inhibitor pyridin-2-ylmethyl N-[(2R)-1-[[(2S,3... 15 8
Coagulation factor X and Trypsin-1 inhibitor N-[(3R)-3-(benzyl... 2 8
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 8 8
Pol polyprotein and Protease inhibitor Palinavir family 1 0
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 4 4
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN7013744... 2 3
Caspase-1 inhibitor (3S)-3-[[(4S,7S,9Z,11aS)-7-(isoquinoline-1... 2 0
Pol polyprotein inhibitor Palinavir deriv. 13 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00398834 CHEMBL199492 Bioactive benzyl (4S,7S,9Z,11aS)-4-[[(3S)-2-hydroxy-5-oxooxolan-3-yl]carbamoyl]-7-(isoquinoline-1-carbonylamino)-6-oxo-3,4,7,8,11,11a-hexahydro-1H-pyrazino[1,2-a]azocine-2-carboxylate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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