CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM9957
Family Name cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor SureCN4026424 family
No. of Seeds 5 No. of Other Members 5
Family Centroid CFAMM00398839 Functional Category Bioactive
Superfamily Coagulation factor X and cAMP-specific 3',5'-cyclic phosphodiesterase 4B Binder Superfamily
Class Class 8

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Prostaglandin G/H synthase 2 Inhibitor Etoricoxib Family 2 99
Prothrombin Inhibitor Ximelegatran Family 8 157
Smoothened homolog Inhibitor Vismodegib Family 1 19
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Neuromedin-K receptor Ligand SB222200 Family 17 235
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Substance-P receptor Ligand TAK-637 Family 18 63
C-C chemokine receptor type 9 Ligand Vercirnon Family 1 1
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
XL-888 family 16 85
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... 7 79
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Branched-chain-amino-acid aminotransferase, cytosolic Inhibito... 1 2
Transient receptor potential cation channel subfamily V member... 6 23
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Poly [ADP-ribose] polymerase 1 Inhibitor 3-ethenylquinoline-8-... 8 4
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Glutamate receptor 1 Ligand Piriqualone Family 8 67
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 7-oxo-7h-dib... 2 3
Prostaglandin G/H synthase 2 Inhibitor 2-(4-(methylsulfonyl)ph... 7 33
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 17 14
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 1 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 2 4
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 10 2
Muscarinic acetylcholine receptor M2 ligand AGN-PC-0745NK family 2 6
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 4 21
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 1
Cellular tumor antigen p53 and Ferritin light chain inhibitor ... 1 2
Coagulation factor X and Trypsin-1 inhibitor 2-(5-carbamimidoy... 5 2
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 36
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
Prelamin-A/C and Pyruvate kinase PKM inhibitor CHEMBL1481187 f... 1 7
Coagulation factor X and Trypsin-1 inhibitor AGN-PC-075TBZ family 2 2
Coagulation factor X and Trypsin-1 inhibitor 4-(3-carbamimidoy... 2 1
Metabotropic glutamate receptor 2 and Metabotropic glutamate r... 5 3
Dipeptidyl peptidase 4 inhibitor AGN-PC-09QN2D family 2 2
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Neuromedin-K receptor ligand 3-methylsulfinyl-N-[(1S)-1-phenyl... 3 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 18 3
Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 2
Cathepsin L1 and Cathepsin S inhibitor N-[(2S)-4-methyl-1-oxo-... 2 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 2 0
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 9 5
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 5 2
Pol polyprotein inhibitor AC1LAHQ9 family 8 15
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 2 3
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 4 0
Glutamate receptor ionotropic, NMDA 2B ligand N-[3-[2-(4-benzy... 2 0
Cannabinoid receptor 1 ligand N-(cyclobutylmethyl)-3-[[4-(meth... 1 1
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 3 11
Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... 12 4
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(3-fluo... 6 4
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(benzen... 4 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 6-(b... 5 5
Hepatocyte growth factor receptor and Protein-tyrosine kinase ... 2 15
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 3
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 2
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
Coagulation factor X inhibitor (Z)-3-(3-carbamimidoylphenyl)-2... 2 2
Coagulation factor X and Trypsin-1 inhibitor SureCN6166035 family 1 2
B1 bradykinin receptor ligand AGN-PC-00RZQU family 2 0
Cytochrome P450 2C9 inhibitor AGN-PC-04XDND family 1 3
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-(3... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 6-(b... 1 0
Coagulation factor X inhibitor (E)-2-fluoro-3-[3-(N'-methylcar... 1 0
Coagulation factor X and Prothrombin inhibitor SureCN7690879 f... 3 0
C-X-C chemokine receptor type 3 ligand AGN-PC-07ZH3V family 1 1
Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor AGN-PC... 2 2
Presenilin-1 and Presenilin-2 inhibitor AGN-PC-075DUF family 2 0
Bifunctional epoxide hydrolase 2 inhibitor 1-(2,4-dimethylphen... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00398841 CHEMBL371037 Bioactive SureCN6180681
CFAMM00398839 CHEMBL198527 Bioactive SureCN4026424
CFAMM00398836 CHEMBL198853 Bioactive (Z)-3-[3-[6-(2-cyanopropan-2-yl)quinolin-8-yl]phenyl]-2-(4-methylsulfonylphenyl)-N-propan-2-ylprop-2-enamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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