CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Integrin alpha-4 Inhibitor R1295 Family
No. of Seeds 18 No. of Other Members 59
Family Centroid CFAMM00127197 Functional Category Clinical Trial Drug with Natural Product
Superfamily Integrin alpha-4 Inhibitor R1295 Superfamily
Class Class 820

Cousin Family NamesSeedsMembers
Alpha adrenergic receptor Ligand Droperidol Family 20 244
5-hydroxytryptamine 2 receptor Ligand Ketanserin Family 10 253
Neuropeptide Y receptor type 1 Ligand BMS-193885 Family 3 11
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand SNAP-6201 Family 41 94
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Voltage-dependent T-type calcium channel subunit alpha-1I Liga... 7 35
Phospholipase D1 Inhibitor Halopemide Family 17 111
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Neuropeptide Y receptor type 1 Ligand N-arylpiperazine Derivat... 13 22
Neuropeptide Y receptor type 1 Ligand N-arylpiperazine Derivat... 5 4
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 3 14
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 5 7
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 4 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Nuclear receptor ROR-gamma and Huntingtin ligand CHEMBL1456749... 1 12
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 7
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 10 0
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6S... 2 4
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 1
Glutamate receptor ionotropic, kainate 1 and Glutamate recepto... 1 12


External ID

Functional Category

Molecule Name

CFAMM00127168 CHEMBL145072 Bioactive methyl 3-[3-[4-(2-carbamoylphenyl)piperazin-1-yl]propylcarbamoyl]-6-(methoxymethyl)-2-oxo-4-(2,4,5-trifluorophenyl)-1,4-dihydropyrimidine-5-carboxylate
CFAMM00127135 CHEMBL185271 Bioactive SNAP-7941
CFAMM00127154 CHEMBL278716 Bioactive methyl (4S)-3-[[(1S,3S)-3-[4-(2-cyanophenyl)piperazin-1-yl]cyclopentyl]carbamoyl]-4-(3,4-difluorophenyl)-6-(methoxymethyl)-2-oxo-1,4-dihydropyrimidine-5-carboxylate
CFAMM00127177 CHEMBL344525 Bioactive methyl 4-(3,4-difluorophenyl)-6-methyl-3-[3-[4-(2-methylphenyl)piperazin-1-yl]propylcarbamoyl]-2-oxo-1,4-dihydropyrimidine-5-carboxylate
CFAMM00127187 CHEMBL357172 Bioactive methyl 3-[3-[4-(2-carbamoylphenyl)piperazin-1-yl]propylcarbamoyl]-6-methyl-2-oxo-4-(3,4,5-trifluorophenyl)-1,4-dihydropyrimidine-5-carboxylate
CFAMM00127203 CHEMBL145190 Bioactive methyl 3-[3-[4-(2-cyanophenyl)piperazin-1-yl]propylcarbamoyl]-4-(3,4-difluorophenyl)-6-methyl-2-oxo-1,4-dihydropyrimidine-5-carboxylate
CFAMM00127195 CHEMBL145443 Bioactive methyl 3-[3-[4-(3-chlorophenyl)piperazin-1-yl]propylcarbamoyl]-4-(3,4-difluorophenyl)-6-methyl-2-oxo-1,4-dihydropyrimidine-5-carboxylate
CFAMM00127210 CHEMBL445577 Bioactive AGN-PC-00GGWT
CFAMM00127218 CHEMBL142236 Bioactive methyl 3-[3-[4-(2-carbamoylphenyl)piperazin-1-yl]propylcarbamoyl]-4-(3,4-difluorophenyl)-6-(methoxymethyl)-2-oxo-1,4-dihydropyrimidine-5-carboxylate
CFAMM00127141 CHEMBL300766 Bioactive methyl (4S)-3-[[(1R,3S)-3-[4-(2-cyanophenyl)piperazin-1-yl]cyclopentyl]carbamoyl]-4-(3,4-difluorophenyl)-6-(methoxymethyl)-2-oxo-1,4-dihydropyrimidine-5-carboxylate
CFAMM00127194 CHEMBL50081 Bioactive AGN-PC-073RCF
CFAMM00127131 CHEMBL342731 Bioactive methyl 4-(3,4-difluorophenyl)-6-methyl-2-oxo-3-[3-(4-phenylpiperazin-1-yl)propylcarbamoyl]-1,4-dihydropyrimidine-5-carboxylate
CFAMM00127148 CHEMBL145394 Bioactive methyl 3-[3-[4-(2-carbamoylphenyl)piperazin-1-yl]propylcarbamoyl]-4-(3,4-difluorophenyl)-6-methyl-2-oxo-1,4-dihydropyrimidine-5-carboxylate
CFAMM00127200 CHEMBL56974 Bioactive methyl (4S)-3-[[(1R,3R)-3-[4-(2-cyanophenyl)piperazin-1-yl]cyclopentyl]carbamoyl]-4-(3,4-difluorophenyl)-6-(methoxymethyl)-2-oxo-1,4-dihydropyrimidine-5-carboxylate
CFAMM00127170 CHEMBL300821 Bioactive methyl (4S)-3-[[(1S,3R)-3-[4-(2-cyanophenyl)piperazin-1-yl]cyclopentyl]carbamoyl]-4-(3,4-difluorophenyl)-6-(methoxymethyl)-2-oxo-1,4-dihydropyrimidine-5-carboxylate
CFAMM00127237 CHEMBL142307 Bioactive methyl 3-[3-[4-(4-chlorophenyl)piperazin-1-yl]propylcarbamoyl]-4-(3,4-difluorophenyl)-6-methyl-2-oxo-1,4-dihydropyrimidine-5-carboxylate
CFAMM00127191 CHEMBL145525 Bioactive methyl 4-(3,4-difluorophenyl)-6-methyl-2-oxo-3-[3-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]propylcarbamoyl]-1,4-dihydropyrimidine-5-carboxylate
CFAMM00127197 DCL000013 Clinical Trial Drug R1295

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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