CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD110
Family Name Histone deacetylase 1 Inhibitor MS-275 Family
No. of Seeds 4 No. of Other Members 41
Family Centroid CFAMM00134299 Functional Category Clinical Trial Drug
Superfamily Histone deacetylase 1 Inhibitor MS-275 Superfamily
Class Class 900

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
5-hydroxytryptamine receptor 3A Ligand Dolasetron Family 12 171
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
HIV-1 protease Inhibitor Atazanavir Family 16 58
Prothrombin Inhibitor Ximelegatran Family 8 157
Neuromedin-K receptor Ligand SB222200 Family 17 235
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Coagulation factor X Inhibitor Otamixaban Family 9 21
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Substance-P receptor Ligand TAK-637 Family 18 63
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
XL-888 family 16 85
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-chlorophenyl)-5-... 2 8
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Transient receptor potential cation channel subfamily V member... 6 23
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 24 64
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Endothelin B receptor Ligand IRL-2500 Family 34 87
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 7-oxo-7h-dib... 2 3
Beta-3 adrenergic receptor and Beta-2 adrenergic receptor liga... 2 22
Neutrophil elastase inhibitor SureCN7284457 family 4 6
Sodium-dependent serotonin transporter and D(2) dopamine recep... 13 2
Pol polyprotein inhibitor Carbamic acid, ((2-hydroxy-1,4-bis(p... 21 1
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 8 8
Retinoic acid receptor alpha and Retinoic acid receptor beta l... 1 2
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 5 2
Substance-P receptor ligand 1-[4-[[3,5-bis(trifluoromethyl)phe... 3 0
Peptide deformylase inhibitor (2R)-N-[(2S)-3,3-dimethyl-1-oxo-... 2 1
Dipeptidyl peptidase 4 inhibitor AGN-PC-09QM95 family 1 1
Substance-K receptor ligand N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)... 2 0
Metabotropic glutamate receptor 5 ligand AGN-PC-075X3Y family 2 6
B1 bradykinin receptor ligand AGN-PC-00CTAF family 1 3
Cathepsin K and Cathepsin S inhibitor dipeptidyl nitrile, 16b ... 2 0
B1 bradykinin receptor ligand methyl 2-[4-[(1R)-1-[[3-[(2-cyan... 8 7
Cannabinoid receptor 1 ligand N-(cyclobutylmethyl)-3-[[4-(meth... 1 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-(cy... 3 2
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN7013744... 2 3
Rho-associated protein kinase 2 inhibitor 2-hydroxyethyl 3-[2-... 2 0
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 4 2
Histone deacetylase 1 inhibitor SureCN2208673 family 1 0
Beta-3 adrenergic receptor ligand SureCN5704018 family 4 1
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 2 1
TGF-beta receptor type-1 ligand Methyl 4-(4-(3-(pyridin-2-yl)-... 1 2
Neutrophil elastase inhibitor SureCN8210283 family 2 2
Protease inhibitor AC1NUJZ5 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00134284 CHEMBL253868 Bioactive SureCN3646556
CFAMM00134318 CHEMBL253870 Bioactive SureCN3777202
CFAMM00134299 DCL000172 Clinical Trial Drug MS-275
CFAMM00134264 DNC001262 Investigative Drug S-9947

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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