CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Cathepsin K Inhibitor Odanacatib Family
No. of Seeds 33 No. of Other Members 84
Family Centroid CFAMM00134943 Functional Category Clinical Trial Drug
Superfamily Cathepsin K Inhibitor Odanacatib Superfamily
Class Class 905

Cousin Family NamesSeedsMembers
C-C chemokine receptor type 5 Ligand AZD5672 Family 25 70
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
72 kDa type IV collagenase Inhibitor Batimastat Family 6 52
Suppressor of tumorigenicity 14 protein and Prothrombin Inhibi... 4 126
Thymidylate synthase Inhibitor N-[tosyl-d-prolinyl]amino-ethan... 1 10
Carbonic anhydrase 2 Inhibitor N-benzyl-4-sulfamoyl-benzamide ... 12 44
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
A disintegrin and metalloproteinase with thrombospondin motifs... 6 33
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 2-valp... 8 5
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Suppressor of tumorigenicity 14 protein Inhibitor 3-tapap Family 15 39
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 3 21
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(2-p... 6 19
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Trypsin Inhibitor Benzamidrazone Analogue Family 16 6
5-hydroxytryptamine receptor 6 ligand N-[[(1R)-6-(3-fluorophen... 8 0
C-C chemokine receptor type 2 ligand SureCN2988733 family 14 17
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-2-[... 14 4
Cathepsin L1 and Cathepsin B inhibitor (2S)-3-methyl-N-[(2S)-4... 7 24
Pol polyprotein inhibitor Lysine Sulfonamide 11c family 3 73
Disintegrin and metalloproteinase domain-containing protein 17... 6 5
Matrix metalloproteinase-9 and Stromelysin-1 inhibitor N-[(2S)... 1 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 4
Carbonic anhydrase 12 and Carbonic anhydrase 2 inhibitor AGN-P... 5 0
Kappa-type opioid receptor and Delta-type opioid receptor liga... 9 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (2... 1 1
C-C chemokine receptor type 2 ligand SureCN2983871 family 9 8
Cathepsin K and Cathepsin L1 inhibitor N-[1-(cyanomethylcarbam... 2 0
Proteasome subunit beta type-5 inhibitor (2S)-N'-(2,2-dimethyl... 2 9
Cathepsin S and Cathepsin K inhibitor SureCN3476615 family 4 1
Cathepsin S and Cathepsin L1 inhibitor SureCN2817685 family 2 0
Cathepsin S and Cathepsin L1 inhibitor (2R)-N-(1-cyanocyclopro... 2 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 7 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 5 5
72 kDa type IV collagenase and Stromelysin-1 inhibitor (3R)-3-... 3 2
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[2-(3-methy... 1 0
Neutrophil elastase inhibitor 1-[(2S)-3-methyl-2-[(4-methylsul... 3 0
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[ethyl-[2-(4... 1 1
C-C chemokine receptor type 2 ligand AGN-PC-03L0Z6 family 1 1
Growth hormone secretagogue receptor type 1 ligand [(3S)-3-ami... 2 6
Cathepsin K inhibitor SureCN4163958 family 3 0
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2J2 inhib... 5 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor N-... 1 0


External ID

Functional Category

Molecule Name

CFAMM00134999 CHEMBL481743 Bioactive SureCN4164604
CFAMM00134974 CHEMBL1669438 Bioactive (2S)-N-(cyanomethyl)-2-[[(1S)-2,2-difluoro-1-[4-(4-methylsulfonylphenyl)phenyl]ethyl]amino]-4-methylpentanamide
CFAMM00134986 CHEMBL252784 Bioactive (2S)-N-[cyano(dicyclopropyl)methyl]-4,4,4-trifluoro-2-[[(1S)-2,2,2-trifluoro-1-[4-(4-methylsulfonylphenyl)phenyl]ethyl]amino]butanamide
CFAMM00135063 CHEMBL252179 Bioactive SureCN4430743
CFAMM00135005 CHEMBL249495 Bioactive SureCN2157644
CFAMM00134997 CHEMBL399359 Bioactive SureCN4193792
CFAMM00134957 CHEMBL437694 Bioactive (2S)-N-(cyanomethyl)-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4-(4-methylsulfanylphenyl)phenyl]ethyl]amino]pentanamide
CFAMM00134990 CHEMBL1288523 Bioactive SureCN3765380
CFAMM00134980 CHEMBL1669437 Bioactive SureCN4117159
CFAMM00134948 CHEMBL207554 Bioactive (2S)-N-(cyanomethyl)-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4-(4-sulfamoylphenyl)phenyl]ethyl]amino]pentanamide
CFAMM00135046 CHEMBL382820 Bioactive (2S)-N-(cyanomethyl)-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4-[4-(4-methylsulfonylphenyl)phenyl]phenyl]ethyl]amino]pentanamide
CFAMM00134984 CHEMBL252382 Bioactive (2S)-N-[(1R)-1-cyano-2-phenylethyl]-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4-(4-methylsulfonylphenyl)phenyl]ethyl]amino]pentanamide
CFAMM00135023 CHEMBL398910 Bioactive (2S,4S)-N-[cyano(dicyclopropyl)methyl]-5,5,5-trifluoro-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4-(4-methylsulfonylphenyl)phenyl]ethyl]amino]pentanamide
CFAMM00135045 CHEMBL1290191 Bioactive SureCN3763659
CFAMM00135060 CHEMBL252571 Bioactive (2S,4R)-N-[cyano(dicyclopropyl)methyl]-5,5,5-trifluoro-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4-(4-methylsulfonylphenyl)phenyl]ethyl]amino]pentanamide
CFAMM00134983 CHEMBL252383 Bioactive (2S)-N-[cyano(dicyclopropyl)methyl]-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4-(4-methylsulfonylphenyl)phenyl]ethyl]amino]pentanamide
CFAMM00134989 CHEMBL1290084 Bioactive (2S)-4,4-dichloro-N-[(1S)-1-cyano-2-phenylethyl]-2-[[(1S)-2,2,2-trifluoro-1-[4-(4-methylsulfonylphenyl)phenyl]ethyl]amino]butanamide
CFAMM00135002 CHEMBL250294 Bioactive SureCN2157117
CFAMM00134994 CHEMBL481814 Bioactive (2S)-4-fluoro-4-methyl-N-(4-oxopyrrolidin-3-yl)-2-[[(1S)-2,2,2-trifluoro-1-[4-(4-methylsulfonylphenyl)phenyl]ethyl]amino]pentanamide
CFAMM00135014 CHEMBL250501 Bioactive SureCN2155895
CFAMM00135028 CHEMBL1289440 Bioactive SureCN12999147
CFAMM00134982 CHEMBL428417 Bioactive SureCN2156521
CFAMM00135037 CHEMBL399733 Bioactive (2S)-N-[cyano(dicyclopropyl)methyl]-4,4-difluoro-2-[[(1S)-2,2,2-trifluoro-1-[4-(4-methylsulfonylphenyl)phenyl]ethyl]amino]pentanamide
CFAMM00135051 CHEMBL252582 Bioactive (2S)-4,4-dichloro-N-[cyano(dicyclopropyl)methyl]-2-[[(1S)-2,2,2-trifluoro-1-[4-(4-methylsulfonylphenyl)phenyl]ethyl]amino]butanamide
CFAMM00134964 CHEMBL248889 Bioactive SureCN7808952
CFAMM00135065 CHEMBL206912 Bioactive (2S)-N-(cyanomethyl)-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4-(3-methylsulfonylphenyl)phenyl]ethyl]amino]pentanamide
CFAMM00134981 CHEMBL1669436 Bioactive SureCN2154985
CFAMM00135019 CHEMBL1288530 Bioactive SureCN3760635
CFAMM00134959 CHEMBL1290303 Bioactive (2S)-N-[(1S)-1-cyano-2-phenylethyl]-2-cyclopropyl-2-[[(1S)-2,2,2-trifluoro-1-[4-(4-methylsulfonylphenyl)phenyl]ethyl]amino]acetamide
CFAMM00134975 CHEMBL399361 Bioactive SureCN4426232
CFAMM00134992 CHEMBL1288529 Bioactive (2S)-N-[(1S)-1-cyano-2-phenylethyl]-3-phenyl-2-[[(1S)-2,2,2-trifluoro-1-[4-(4-methylsulfonylphenyl)phenyl]ethyl]amino]propanamide
CFAMM00134943 DCL000185 Clinical Trial Drug Odanacatib
CFAMM00134958 DNC006434 Investigative Drug L-873724

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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