CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD12
Family Name Serine/threonine-protein kinase Chk1 and Serine/threonine-protein kinase Chk2 Inhibitor XL844 Family
No. of Seeds 23 No. of Other Members 121
Family Centroid CFAMM00127262 Functional Category Clinical Trial Drug
Superfamily Serine/threonine-protein kinase Chk1 and Serine/threonine-protein kinase Chk2 Inhibitor XL844 Superfamily
Class Class 822

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Mepyramine Family 5 65
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Nuclear factor NF-kappa-B p100 subunit Inhibitor GMX1777 Family 3 7
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Neuronal acetylcholine receptor subunit alpha-4 Ligand Isproni... 49 172
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
AP26113 family 16 90
SB1518 family 7 103
Serine/threonine-protein kinase Chk1 Inhibitor LY2603618 Family 2 1
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Glucokinase Inhibitor GKA1 Family 2 67
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Tissue-type plasminogen activator Inhibitor N-(7-benzyloxy-iso... 4 37
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Melanin-concentrating hormone receptor 1 Ligand Gnf-pf-2322 Fa... 3 95
Metabotropic glutamate receptor 5 Ligand (3-ethoxy-pyridin-2-y... 3 12
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
Platelet-derived growth factor receptor alpha and Fibroblast g... 3 47
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 3
Reverse transcriptase Inhibitor UK-129485 Family 23 221
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
5-hydroxytryptamine receptor 1A Ligand CP-293019 Family 9 24
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 22
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 11
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 3
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Bifunctional epoxide hydrolase 2 inhibitor SureCN3216677 family 4 9
Vascular endothelial growth factor receptor 2 ligand F3284-701... 1 2
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 10
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 14
Cellular tumor antigen p53 and Prelamin-A/C inhibitor CHEMBL14... 2 11
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Lethal factor and Dual specificity protein kinase CLK4 inhibit... 1 3
Inositol monophosphatase 1 inhibitor CHEMBL1588383 family 1 6
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 6 12
Calcium/calmodulin-dependent protein kinase kinase 2 and Focal... 3 17
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Ephrin type-B receptor 4 ligand SureCN5131922 family 4 0
Ephrin type-B receptor 4 and Vascular endothelial growth facto... 2 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 2
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 4 2
Cathepsin K and Cathepsin L1 inhibitor CHEBI:43424 family 2 0
Corticotropin-releasing factor receptor 1 ligand AGN-PC-009TSL... 3 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 16 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 1
Serine/threonine-protein kinase Chk1 inhibitor Chk1_49 family 6 0
ALK tyrosine kinase receptor ligand CHEMBL1946804 family 3 0
Growth hormone secretagogue receptor type 1 and Potassium volt... 3 0
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Insulin-like growth factor 1 receptor ligand 4-(2,3-dihydroind... 1 0
Wee1-like protein kinase and ALK tyrosine kinase receptor liga... 1 9
Serine/threonine-protein kinase Chk1 and Ribosomal protein S6 ... 4 1
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 12 2
Serine/threonine-protein kinase Chk1 inhibitor N-pyrazinylurea... 1 9
Serine/threonine-protein kinase Chk1 inhibitor AGN-PC-046QRM f... 1 2
Serine/threonine-protein kinase Chk1 inhibitor CHEMBL400574 fa... 26 4
Serine/threonine-protein kinase Chk1 inhibitor macrocyclic inh... 24 0
Serine/threonine-protein kinase Chk1 inhibitor CHEMBL398875 fa... 6 0
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 2
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 6 13
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 18 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 0
Serine/threonine-protein kinase Chk1 inhibitor macrocyclic inh... 5 0
TRAF2 and NCK-interacting protein kinase and Serine/threonine-... 2 2
TRAF2 and NCK-interacting protein kinase inhibitor 4-methoxy-3... 4 1
Serine/threonine-protein kinase Chk1 inhibitor AGN-PC-076BW0 f... 2 0
Motilin receptor ligand SureCN2765637 family 1 1
Focal adhesion kinase 1 inhibitor 2-[[2-(2-methoxy-4-morpholin... 2 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 3 10
Dihydrofolate reductase and Dihydrofolate reductase type 1 inh... 8 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 2 inhibi... 1 3
Alpha-2C adrenergic receptor and Alpha-2B adrenergic receptor ... 2 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
Bifunctional epoxide hydrolase 2 and Voltage-dependent L-type ... 2 1
LIM domain kinase 2 and LIM domain kinase 1 inhibitor SureCN36... 1 1
TGF-beta receptor type-1 ligand SureCN373216 family 3 14
Tyrosine-protein kinase receptor Tie-1 and Receptor-type tyros... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 4 3
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Glucokinase inhibitor 4-methyl-N-[3-phenylmethoxy-5-(pyridin-2... 1 8
Corticotropin-releasing factor receptor 1 ligand N-[(1R,2S)-2-... 3 0
TGF-beta receptor type-1 ligand 2wou family 1 0
Huntingtin and Nuclear receptor ROR-gamma ligand CHEMBL1324975... 1 0
Sodium channel protein type 9 subunit alpha and Sodium channel... 2 0
4-[(4-pyridin-1-ium-2-ylpiperazin-1-yl)methyl]chromen-2-one NP... 9 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00127270 CHEMBL236230 Bioactive AGN-PC-076BW6
CFAMM00127368 CHEMBL235604 Bioactive AGN-PC-076BWZ
CFAMM00127384 CHEMBL393569 Bioactive CHEMBL393569
CFAMM00127376 CHEMBL193117 Bioactive urea-based inhibitor 2c
CFAMM00127336 CHEMBL375097 Bioactive macrocyclic inhibitor 5c
CFAMM00127423 CHEMBL235381 Bioactive CHEMBL235381
CFAMM00127367 CHEMBL235605 Bioactive AGN-PC-076BX0
CFAMM00127392 CHEMBL394668 Bioactive SureCN6509516
CFAMM00127335 CHEMBL426811 Bioactive urea-based inhibitor 2b
CFAMM00127414 CHEMBL542007 Bioactive CHEMBL542007
CFAMM00127290 CHEMBL425904 Bioactive SureCN5865729
CFAMM00127373 CHEMBL223512 Bioactive 18-Chloro-11,12,13,14-Tetrahydro-1h,10h-8,4-(Azeno)-9,15,1,3,6-Benzodioxatriazacycloheptadecin-2-One
CFAMM00127391 CHEMBL220002 Bioactive macrocyclic inhibitor 5b
CFAMM00127334 CHEMBL235161 Bioactive CHEMBL235161
CFAMM00127324 CHEMBL238145 Bioactive CHEMBL238145
CFAMM00127279 CHEMBL236644 Bioactive AGN-PC-007B0R
CFAMM00127389 CHEMBL444365 Bioactive CHEMBL444365
CFAMM00127352 CHEMBL235368 Bioactive AGN-PC-076BVW
CFAMM00127369 CHEMBL235606 Bioactive AGN-PC-076BX1
CFAMM00127302 CHEMBL238351 Bioactive CHEMBL238351
CFAMM00127386 CHEMBL235163 Bioactive CHEMBL235163
CFAMM00127262 DCL000017 Clinical Trial Drug XL844

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21767 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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