CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD120
Family Name Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Family
No. of Seeds 16 No. of Other Members 138
Family Centroid CFAMM00135087 Functional Category Clinical Trial Drug with Natural Product
Superfamily 5-hydroxytryptamine receptor 2A and Serine/threonine-protein kinase PLK1 Binder Superfamily
Class Class 906

Cousin Family NamesSeedsMembers
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Acetylcholinesterase Inhibitor Rivastigmine Family 2 59
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Beta-1 adrenergic receptor Ligand Metoprolol Family 29 90
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
Acetylcholinesterase Inhibitor Neostigmine Family 4 76
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
HIV-1 protease Inhibitor Lopinavir Family 4 25
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
Zucapsacin family 7 177
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
C-C chemokine receptor type 5 Ligand GW873140 Family 6 78
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
Beta-3 adrenergic receptor Ligand Amibegron Family 8 46
Substance-P receptor Ligand Ezlopitant Family 10 207
5-hydroxytryptamine receptor 2A Ligand Pimavanserin Family 4 23
Dapoxetine family 3 40
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Arachidonate 5-lipoxygenase Inhibitor Bw A4C Family 3 18
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Extracellular calcium-sensing receptor Ligand Nps 568 Family 5 54
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 2 11
5-hydroxytryptamine receptor 1A Ligand Robalzotan Family 9 41
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Histamine H3 receptor Ligand A-317920 Family 9 240
Histamine H3 receptor Ligand A-331440 Family 6 7
Histamine H3 receptor Ligand UCL-2138 Family 23 172
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
Cathepsin F and Cruzipain Inhibitor Benzoyl-arginine-alanine-m... 49 348
Peptidyl-prolyl cis-trans isomerase A Inhibitor 7-amino-4-meth... 4 59
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 16
Voltage-dependent N-type calcium channel subunit alpha-1B Liga... 2 2
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Cathepsin B and Cathepsin L1 Inhibitor MDL-2170 Family 17 24
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 4-hy... 2 13
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Histamine H3 receptor Ligand A-349821 Family 49 228
Adenosine receptor A3 and Muscarinic acetylcholine receptor M2... 4 31
Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-... 5 24
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Dipeptidyl peptidase 4 Inhibitor (2-chloro-6-phenoxyphenyl)met... 17 24
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Oxytocin receptor Ligand [mpa1, D-tyr(et)2, D-tic7]ot Family 43 26
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 41
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Fatty-acid amide hydrolase 1 Inhibitor N-butylcarbamic Acid Bi... 9 31
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 2
Sodium-dependent serotonin transporter Inhibitor 4-(2-((dimeth... 3 1
Urotensin-2 receptor Ligand SB-436811 Family 6 71
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Leukotriene A-4 hydrolase Inhibitor (r/s)-2-((4-phenoxyphenoxy... 7 18
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
Fatty-acid amide hydrolase 1 Inhibitor 3-(trifluoromethyl)phen... 3 0
Fatty-acid amide hydrolase 1 Inhibitor Propan-2-one O-4-butoxy... 1 1
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 10 15
Cytochrome P450 2D6 Inhibitor 4-methylaminomethyl-7-methoxycou... 3 80
Fatty-acid amide hydrolase 1 Inhibitor Phenmedipham Family 2 5
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Arachidonate 5-lipoxygenase Inhibitor 2-(4-butoxy-phenyl)-n-hy... 3 9
5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Amine oxidase [flavin-containing] B Inhibitor (r)-n2-{4-[(3-ch... 3 0
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Fatty-acid amide hydrolase 1 Inhibitor 8-phenyloctylcarbamic A... 12 1
Fatty-acid amide hydrolase 1 Inhibitor Adamant-1-ylcarbamic Ac... 1 0
Fatty-acid amide hydrolase 1 Inhibitor 3-(4,5-dihydrooxazol-2-... 6 11
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Pol polyprotein inhibitor 180968-31-4 family 8 13
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
Prothrombin and Tissue-type plasminogen activator inhibitor CH... 10 5
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
Matrilysin and 72 kDa type IV collagenase inhibitor (3S,6R,7S)... 2 2
Neutrophil elastase inhibitor (2S)-N-[(3S)-6-benzamido-5,5-dif... 6 10
Growth hormone secretagogue receptor type 1 ligand 2-amino-2-m... 1 0
Cathepsin K inhibitor [1-(3-methoxyphenyl)-2-methylpropan-2-yl... 2 10
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 8 4
Leukotriene A-4 hydrolase inhibitor 3-[3-(4-benzylphenoxy)prop... 2 0
Histamine H3 receptor ligand 1-(4-pentan-3-ylpiperazin-1-yl)-2... 1 1
E3 ubiquitin-protein ligase XIAP inhibitor N-METHYLALANYL-3-ME... 3 14
Renin inhibitor (1R,5S)-N-cyclopropyl-N-[(3-methoxy-2-methylph... 4 4
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 6 1
3-hydroxyacyl-CoA dehydrogenase type-2 and Retinal dehydrogena... 1 15
Sodium-dependent serotonin transporter and Sodium-dependent no... 1 0
Substance-P receptor ligand AGN-PC-075NP5 family 4 8
Disintegrin and metalloproteinase domain-containing protein 17... 2 0
Stromelysin-1 and Matrix metalloproteinase-9 inhibitor AGN-PC-... 26 12
Dipeptidyl peptidase 4 and Seprase inhibitor (2R)-2-[4-[[[(2S)... 17 19
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Growth hormone secretagogue receptor type 1 ligand tert-butyl ... 5 4
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6S... 1 0
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 1 0
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
Growth hormone secretagogue receptor type 1 ligand 2-benzylsul... 2 0
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 12 54
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 3
Cholinesterase and Acetylcholinesterase inhibitor AGN-PC-009M2... 1 6
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 6 3
Pol polyprotein inhibitor MDL 74538 family 11 1
Collagenase 3 and Matrix metalloproteinase-9 inhibitor (4R)-N-... 1 2
Kappa-type opioid receptor and Cytochrome P450 2D6 ligand Sure... 4 3
NS3 inhibitor Proline-Based Macrocycle 24 family 6 6
Bifunctional epoxide hydrolase 2 inhibitor 1-(1-adamantyl)-3-[... 2 0
Carbonic anhydrase 7 and Carbonic anhydrase 14 inhibitor 4-(6-... 7 8
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[(2... 10 12
Angiotensin-converting enzyme and Neprilysin inhibitor (2S,5R)... 15 3
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 1 0
Beta-secretase 1 and Cathepsin D inhibitor N-[(2S,3R)-1-(3,5-d... 10 15
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-[cyano-(2-meth... 1 0
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 5 1
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 7 1
Motilin receptor ligand SureCN74051 family 1 0
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Beta-secretase 1 and Cathepsin D inhibitor N-[(2S,3R)-4-[[(4S)... 4 0
Angiotensin-converting enzyme 2 and Neprilysin inhibitor (2S)-... 6 1
Renin inhibitor (3S,6R)-6-(cyclohexylmethyl)-7-hydroxy-7-[[(2S... 1 0
Pol polyprotein inhibitor SDZ PRI 053 family 8 1
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 2 0
C-C chemokine receptor type 1 ligand SureCN8184421 family 11 10
Plasmepsin-2 and Cathepsin D inhibitor N-[2-(1,3-benzodioxol-5... 4 0
Pol polyprotein inhibitor N-[2-Hydroxy-2-(8-Isopropyl-6,9-Diox... 7 6
Disintegrin and metalloproteinase domain-containing protein 17... 2 0
Follicle-stimulating hormone receptor ligand SureCN6140614 family 2 8
Histamine H3 receptor ligand SureCN7244264 family 1 0
Cathepsin S and Cathepsin L1 inhibitor benzyl N-[(2S)-1-oxo-1-... 2 2
Pol polyprotein inhibitor (3S)-N-tert-butyl-2-[(2R)-2-[(3S,6S,... 3 1
Stromelysin-1 and Interstitial collagenase inhibitor (2R)-2-[4... 4 1
Substance-P receptor ligand (5S,10S)-5-(4-fluorophenyl)-10-(2-... 3 2
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 6
Kappa-type opioid receptor ligand AGN-PC-03TFVP family 1 10
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 11
Scytalone dehydratase inhibitor 2-cyano-N-[(1S,2R)-1-(2-cyanop... 5 0
Chymase inhibitor 1,3-bis[(3-methoxyphenyl)methyl]-1,3-diazeti... 3 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 0
C-C chemokine receptor type 5 ligand (4-chlorophenyl) N-[1-[(4... 2 2
Growth hormone secretagogue receptor type 1 ligand N-benzyl-2-... 5 19
Renin inhibitor (2S,4S,5S,7S)-5-amino-4-hydroxy-7-[[4-methoxy-... 2 0
Neuropeptide Y receptor type 1 and Sodium-dependent serotonin ... 2 7
72 kDa type IV collagenase and Interstitial collagenase inhibi... 2 0
Scytalone dehydratase inhibitor AGN-PC-074L4J family 1 0
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-006SR... 1 2
Interstitial collagenase and Matrix metalloproteinase-9 inhibi... 2 1
Metabotropic glutamate receptor 2 ligand (5R)-3-[[4-(4-ethoxyp... 3 9
Sigma non-opioid intracellular receptor 1 ligand (1R,5S)-9-[(4... 3 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 2 3
Dipeptidyl peptidase 4 inhibitor 7-[(3R)-3-amino-4-(2,4,5-trif... 2 0
Beta-lactamase and Histone-lysine N-methyltransferase 2A inhib... 1 7
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-0A9S9E... 1 0
N-acylethanolamine-hydrolyzing acid amidase inhibitor (4-pheny... 1 0
Lysosomal alpha-glucosidase inhibitor MLS000587024 family 1 0
Arachidonate 5-lipoxygenase inhibitor AGN-PC-000I3M family 2 6
Arachidonate 5-lipoxygenase inhibitor AGN-PC-074BAX family 1 0
Sodium channel protein type 1 subunit alpha and Sodium channel... 2 0
Putative NP ZINC04061066 Family 18 0
2-[(1R,4aS,8aS)-4a-hydroxy-1-(4-methoxyphenyl)-2,3,4,5,6,7,8,8... 1 0
N'-[[4-(4-methoxyphenyl)oxan-4-yl]methyl]-N-[(1-phenylcyclopen... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00135189 DCL000949 Clinical Trial Drug Ralfinamide
CFAMM00135087 DCL000189 Clinical Trial Drug ON 019190.Na
CFAMM00135139 DNC013331 Investigative Drug (S)-N2-[4-(benzyloxy)benzyl]alaninamide
CFAMM00135116 DNC013325 Investigative Drug (S)-N2-{4-[(3-fluorobenzyl)oxy]benzyl}serinamide
CFAMM00135223 DNC010396 Investigative Drug 2-fluorophenyl 1-(4-butoxyphenyl)propylcarbamate
CFAMM00135138 DNC013330 Investigative Drug (R)-N2-{4-[(3-fluorobenzyl)oxy]benzyl}alaninamide
CFAMM00135115 DNC013320 Investigative Drug N2-{4-[(3-fluorobenzyl)oxy]benzyl}glycinamide
CFAMM00135137 DNC013333 Investigative Drug N2-{4-[(3-chlorobenzyl)oxy]benzyl}glycinamide
CFAMM00135220 DNC010401 Investigative Drug phenyl 1-(4-butoxyphenyl)propylcarbamate
CFAMM00135113 DNC013328 Investigative Drug (R)-N2-{4-[(3-chlorobenzyl)oxy]benzyl}alaninamide
CFAMM00135226 DNC010399 Investigative Drug 4-fluorophenyl 1-(4-butoxyphenyl)propylcarbamate
CFAMM00135112 DNC013329 Investigative Drug (S)-N2-{4-[(3-chlorobenzyl)oxy]benzyl}alaninamide
CFAMM00135179 DNC013319 Investigative Drug N2-{4-[(4-chlorobenzyl)oxy]benzyl}glycinamide
CFAMM00135118 DNC013326 Investigative Drug (S)-N2-[4-(benzyloxy)benzyl]serinamide
CFAMM00135178 DNC013318 Investigative Drug N2-[4-(benzyloxy)benzyl]glycinamide
CFAMM00135117 DNC013327 Investigative Drug (S)-N2-{4-[(4-chlorobenzyl)oxy]benzyl}alaninamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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