CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD122
Family Name Neuromedin-K receptor Ligand Osanetant Family
No. of Seeds 38 No. of Other Members 192
Family Centroid CFAMM00135375 Functional Category Clinical Trial Drug
Superfamily Neuromedin-K receptor Ligand Osanetant Superfamily
Class Class 908

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Azelastine Family 14 29
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Amine oxidase [flavin-containing] A Inhibitor Moclobemide Family 5 255
DNA Binder Procarbazine Family 8 358
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
Substance-K receptor and Substance-P receptor Ligand DNK-333 F... 15 95
Tumor necrosis factor Inhibitor Talactoferrin Alfa Family 26 131
Bavisant family 9 65
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 11 67
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Poly(ADP-ribose) glycohydrolase Inhibitor N-bis-(3-phenyl-prop... 3 7
Prothrombin Inhibitor D-leucyl-n-(3-chlorobenzyl)-l-prolinamid... 18 168
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-m... 8 37
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor Bexlosteride... 5 23
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 5-(4-chloro-... 10 52
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 41 24
Dipeptidyl peptidase 4 Inhibitor N4-(4-chlorobenzyl)-2,4-diami... 10 22
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 2 23
Sodium-dependent dopamine transporter and Sodium-dependent nor... 19 28
Aminopeptidase N Inhibitor N1-(4-chlorobenzyl)-2-benzyl-n3-hyd... 9 86
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-3'... 14 11
Integrin beta-2 and Intercellular adhesion molecule 1 inhibito... 3 18
Substance-P receptor and Substance-K receptor ligand AGN-PC-07... 1 1
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand [2... 2 4
Substance-K receptor and Substance-P receptor ligand N-[4-[[4-... 1 4
Melanocortin receptor 4 and Melanocortin receptor 5 ligand Sur... 25 14
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 1 1
C-C chemokine receptor type 5 ligand AC1L9USC family 3 2
Coagulation factor X inhibitor 3-amino-4-chloro-N-[(1R)-2-[4-(... 1 1
P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-2,5-dichlor... 3 4
Substance-P receptor ligand AGN-PC-075NUD family 4 1
Pyruvate kinase PKM and Huntingtin inhibitor CHEMBL1455935 family 1 3
Substance-P receptor ligand 4-[1-[2-[1-(cyclopropylmethyl)-3-(... 10 6
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 2
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 9 0
Substance-K receptor ligand (5S)-1-(2-cyclopropylethyl)-5-(3,4... 10 0
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 5 0
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 3 0
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 2 0
Substance-P receptor ligand 1-(cyclohexylmethyl)-5-(3,4-dichlo... 8 1
D(3) dopamine receptor and Alpha-1B adrenergic receptor ligand... 11 8
Prelamin-A/C and Ras-related protein Rab-9A inhibitor CHEMBL15... 1 7
Sigma non-opioid intracellular receptor 1 ligand 1-[2-(3,4-dic... 8 4
Substance-P receptor and Substance-K receptor ligand 3,5-dichl... 7 2
Substance-K receptor and Substance-P receptor ligand N-[(2Z,3R... 26 4
Substance-P receptor and Substance-K receptor ligand 3,5-dichl... 19 0
Neuromedin-K receptor ligand SureCN2477089 family 2 4
Neuromedin-K receptor ligand (1S,2R)-1-(3,4-dichlorophenyl)-N-... 8 0
Prothrombin inhibitor AGN-PC-09QJ23 family 2 5
Prostaglandin D2 receptor 2 ligand SureCN4942606 family 2 8
Substance-K receptor ligand AGN-PC-0759BS family 3 6
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 6 0
Melanocortin receptor 4 and Melanocortin receptor 5 ligand AC1... 7 31
Ceramide glucosyltransferase and Cytochrome P450 3A4 inhibitor... 7 16
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[[2-(2,4-dic... 4 9
Vasopressin V1a receptor ligand N-[(2R)-3-(4-chlorophenyl)-1-[... 6 0
Dipeptidyl peptidase 8 inhibitor (2S)-2-amino-4-[4-[bis(4-fluo... 2 9
Kappa-type opioid receptor ligand 3,4-dichloro-N-[2-[[(1S)-2-[... 1 0
Melanocortin receptor 4 ligand (3R)-N-[(2R)-3-(4-chlorophenyl)... 6 9
Substance-K receptor ligand SureCN3083325 family 4 0
Transporter and Sodium-dependent dopamine transporter inhibito... 6 1
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075C6K ... 3 22
Melanin-concentrating hormone receptor 1 ligand 1-(3-acetyl-1,... 8 4
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 2 0
Lysosomal Pro-X carboxypeptidase inhibitor (2S,3S)-2-[(2-amino... 3 3
Oxytocin receptor and Vasopressin V2 receptor ligand (2R)-2-(2... 4 2
C-C chemokine receptor type 5 ligand AGN-PC-075XOD family 2 0
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (3R... 7 1
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (3R... 6 1
Sodium-dependent serotonin transporter and Sodium-dependent do... 6 3
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 8 4
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 11 9
Substance-P receptor ligand AGN-PC-073QYE family 6 11
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 4
P2X purinoceptor 7 inhibitor AGN-PC-050YWL family 2 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Melanocortin receptor 4 and Cytochrome P450 3A4 ligand 2-amino... 52 12
P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-2-chloro-5-... 3 1
C-C chemokine receptor type 1 ligand 4-chloro-N-[(2R)-1-[(4S)-... 6 3
C-C chemokine receptor type 1 ligand 3-[2-(carbamoylamino)phen... 2 1
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 4
Histamine H3 receptor ligand AGN-PC-01WA6E family 10 1
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 6 0
Substance-P receptor and Substance-K receptor ligand N-[(2Z)-3... 5 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 2 6
Sodium-dependent dopamine transporter and Transporter inhibito... 6 0
Substance-P receptor and Potassium voltage-gated channel subfa... 5 1
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
Nociceptin receptor and Mu-type opioid receptor ligand (1R,5R)... 4 9
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 1
Free fatty acid receptor 1 ligand (3R,4R)-3-(3,4-dichloropheny... 1 0
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[(3,4-dichlo... 1 0
Neuromedin-K receptor and Substance-K receptor ligand AGN-PC-0... 2 0
Aldose reductase inhibitor SureCN8804611 family 2 0
Substance-P receptor ligand 1-benzyl-3-[bis(4-chlorophenyl)met... 1 3
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor N-[(2S)-1-[[... 1 3
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand 2,6-d... 1 1
Voltage-dependent T-type calcium channel subunit alpha-1I and ... 1 0
C-C chemokine receptor type 3 ligand AGN-PC-075CFD family 2 0
Sodium- and chloride-dependent glycine transporter 1 inhibitor... 1 0
Putative Bioactive [3-[benzoyl(hydroxy)amino]-1-(3,4-dichlorop... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00135352 CHEMBL109092 Bioactive AGN-PC-074W5E
CFAMM00135523 CHEMBL370013 Bioactive 1-[2-[(3S)-1-benzoyl-3-(3,4-dichlorophenyl)pyrrolidin-3-yl]ethyl]-4-phenylpiperidine-4-carboxamide
CFAMM00135391 CHEMBL56143 Bioactive N-[2-(3,4-dichlorophenyl)-4-[4-(4-hydroxyheptan-4-yl)piperidin-1-yl]butyl]-N-methylbenzamide
CFAMM00135462 CHEMBL1682672 Bioactive N'-[1-[[(1R,2S)-2-[benzyl(methyl)carbamoyl]-2-(3,4-dichlorophenyl)cyclopropyl]methyl]-4-phenylpiperidin-4-yl]-N'-methyloxamide
CFAMM00135358 CHEMBL110219 Bioactive SureCN6470617
CFAMM00135468 CHEMBL106300 Bioactive (2S)-2-amino-1-[4-[[2-[(2R)-2-(3,4-dichlorophenyl)-4-(3,5-dimethylbenzoyl)piperazin-1-yl]-2-oxoethyl]amino]piperidin-1-yl]-2-phenylethanone
CFAMM00135508 CHEMBL56481 Bioactive AGN-PC-0A7LTQ
CFAMM00135461 CHEMBL1682668 Bioactive methyl N-[1-[[(1R,2S)-2-[benzyl(methyl)carbamoyl]-2-(3,4-dichlorophenyl)cyclopropyl]methyl]-4-phenylpiperidin-4-yl]carbamate
CFAMM00135428 CHEMBL1682624 Bioactive SureCN2479210
CFAMM00135423 CHEMBL27463 Bioactive SureCN7834929
CFAMM00135434 CHEMBL69335 Bioactive N-[2-(3,4-dichlorophenyl)-4-(4-phenylpiperidin-1-yl)butyl]-N-methylbenzamide
CFAMM00135440 CHEMBL443264 Bioactive N-[2-(3,4-dichlorophenyl)-4-[4-[(E)-C-ethyl-N-hydroxycarbonimidoyl]piperidin-1-yl]butyl]-N-methylbenzamide
CFAMM00135513 CHEMBL1681797 Bioactive AGN-PC-09QNBD
CFAMM00135453 CHEMBL320487 Bioactive 2-[(1-benzylpiperidin-4-yl)amino]-1-[(2R)-2-(3,4-dichlorophenyl)-4-(3,5-dimethylbenzoyl)piperazin-1-yl]ethanone
CFAMM00135322 CHEMBL58638 Bioactive N-[2-(3,4-dichlorophenyl)-4-[4-[(E)-C-ethyl-N-methoxycarbonimidoyl]piperidin-1-yl]butyl]-N-methylbenzamide
CFAMM00135408 CHEMBL417940 Bioactive SureCN9079365
CFAMM00135492 CHEMBL1682634 Bioactive SureCN2476213
CFAMM00135459 CHEMBL301437 Bioactive AGN-PC-074AIT
CFAMM00135506 CHEMBL2311148 Bioactive N-[1-[3-[(3R)-1-benzoyl-3-(3,4-dichlorophenyl)piperidin-3-yl]propyl]-4-(3-tritiophenyl)piperidin-4-yl]-N-methylacetamide
CFAMM00135534 CHEMBL320548 Bioactive 2-[(1-benzylpiperidin-4-yl)amino]-1-[(2S)-2-(3,4-dichlorophenyl)-4-(3,5-dimethylbenzoyl)piperazin-1-yl]ethanone
CFAMM00135439 CHEMBL2067979 Bioactive N-[(2S)-4-(4-acetamido-4-phenylpiperidin-1-yl)-2-(3,4-dichloro-5-tritiophenyl)butyl]-N-methylbenzamide
CFAMM00135512 CHEMBL2115073 Bioactive N-[(2S)-2-(3,4-dichlorophenyl)-4-[4-(3-hydroxypentan-3-yl)piperidin-1-yl]butyl]-N-methylbenzamide
CFAMM00135311 CHEMBL1682669 Bioactive SureCN2479436
CFAMM00135374 CHEMBL59542 Bioactive AGN-PC-03OU0H
CFAMM00135511 CHEMBL2115072 Bioactive AGN-PC-03OU0I
CFAMM00135406 CHEMBL106816 Bioactive (2S)-2-amino-1-[4-[[2-[(2R)-2-(3,4-dichlorophenyl)-4-(3,5-dimethylbenzoyl)piperazin-1-yl]-2-oxoethyl]amino]piperidin-1-yl]-3-phenylpropan-1-one
CFAMM00135444 CHEMBL567198 Bioactive SureCN297642
CFAMM00135399 CHEMBL108955 Bioactive (2R)-2-amino-1-[4-[[2-[(2R)-2-(3,4-dichlorophenyl)-4-(3,5-dimethylbenzoyl)piperazin-1-yl]-2-oxoethyl]amino]piperidin-1-yl]-3-phenylpropan-1-one
CFAMM00135483 CHEMBL71918 Bioactive AGN-PC-074GBA
CFAMM00135463 CHEMBL2111522 Bioactive N-[2-(3,4-dichlorophenyl)-4-[4-[(Z)-C-ethyl-N-hydroxycarbonimidoyl]piperidin-1-yl]butyl]-N-methylbenzamide
CFAMM00135319 CHEMBL56835 Bioactive SureCN676170
CFAMM00135379 CHEMBL106608 Bioactive AGN-PC-074W4V
CFAMM00135430 CHEMBL1682628 Bioactive AGN-PC-09QGWG
CFAMM00135456 CHEMBL1682666 Bioactive SureCN2478814
CFAMM00135530 CHEMBL1628678 Bioactive N-[1-[3-[(3R)-1-benzoyl-3-(3,4-dichlorophenyl)piperidin-3-yl]propyl]-4-phenylpiperidin-4-yl]-N-(tritritiomethyl)acetamide
CFAMM00135372 CHEMBL362394 Bioactive AGN-PC-072OUD
CFAMM00135403 DCL000220 Clinical Trial Drug Saredutant
CFAMM00135375 DCL000191 Clinical Trial Drug Osanetant

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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