CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD125
Family Name Sphingosine kinase 2 Inhibitor Phenoxodiol Family
No. of Seeds 24 No. of Other Members 682
Family Centroid CFAMM00135659 Functional Category Clinical Trial Drug with Human Metabolite & Natural Product
Superfamily Sphingosine kinase 2 Inhibitor Phenoxodiol Superfamily
Class Class 911

Cousin Family NamesSeedsMembers
Thyroid hormone receptor alpha ligand thyroid hormone analog L... 10 61
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Prostaglandin G/H synthase 2 Inhibitor Diflunisal Family 7 421
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Cannabinoid receptor 1 Ligand Marinol Family 32 454
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Cyclooxygenase Inhibitor Fenoprofen Family 4 1077
Prostaglandin G/H synthase 1 Inhibitor Salicyclic Acid Family 3 39
Cyclooxygenase inhibitor salicylate derivative Aspirin family 3 234
Prostaglandin G/H synthase 2 Inhibitor Nabumetone Family 4 267
Signal transducer and activator of transcription 3 Inhibitor A... 5 249
Vitamin K epoxide reductase complex subunit 1 Inhibitor Warfar... 9 508
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor Mycophenola... 4 353
Heat shock protein 90, putative Inhibitor Cromoglicate Family 14 2827
Tyrosinase Inhibitor Monobenzone Family 6 197
Oestrogen receptor ligand Dienestrol Family 35 440
DNA Binder Methoxsalen Family 10 1638
Oestrogen receptor Ligand Chlorotrianisene Family 2 102
Vitamin K-dependent gamma-carboxylase Inhibitor Anisindione Fa... 3 243
D-alanyl-D-alanine carboxypeptidase Inhibitor B-lactams Family 59 1364
Aldehyde oxidase Inhibitor Isovanillin Family 6 429
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Hidrosmin family 14 61
Ipriflavone family 62 2480
Rotenone family 16 107
taste receptor Ligand Cynarin Family 6 124
Agrimophol family 10 22
Salicin family 5 629
Sodium/glucose cotransporter 2 Inhibitor Empagliflozin Family 32 52
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
NAD-dependent protein deacetylase sirtuin-1 Inhibitor SRT501 F... 19 88
Steryl-sulfatase Inhibitor Stx 64 Family 7 160
Muscarinic acetylcholine receptor M1 Ligand GSK1034702 Family 7 148
Glucokinase Inhibitor R7201 Family 22 105
Translocator protein Inhibitor Dextofisopam Family 3 250
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Oxi4503 family 4 27
Acolbifene family 10 115
Free fatty acid receptor 1 Ligand TAK-875 Family 2 54
TS-071 family 8 36
Interleukin-1 beta Inhibitor Diacerein Family 3 77
Integrase Inhibitor L-708,906 Family 1 8
Endothelin-1 receptor Ligand PD156707 Family 41 211
Estrogen receptor beta Ligand 2-(4-hydroxy-phenyl)benzofuran-5... 5 82
Proto-oncogene tyrosine-protein kinase Src Inhibitor Malonic A... 1 34
Phospholipase A2 Inhibitor P-anisic Acid Family 2 178
Peroxisome proliferator-activated receptor gamma Ligand (2s)-2... 10 126
Arachidonate 15-lipoxygenase Inhibitor Isoscopoletin Family 5 98
Platelet-activating factor receptor Ligand L-652731 Family 5 116
Cytosolic phospholipase A2 Inhibitor 1,1,1-trifluoro-6-(4-hexy... 9 86
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 Ligand... 4 26
Glucocorticoid receptor Ligand 1-methoxy-6-phenyl-6h-benzo[c]c... 2 22
Aromatase and DNA-dependent protein kinase catalytic subunit I... 6 19
DNA-dependent protein kinase catalytic subunit Inhibitor 7-pro... 5 49
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 6-ph... 1 18
Oestrogen receptor and Estrogen receptor beta Ligand 7-chloro-... 2 27
Phospholipase A2 Inhibitor 3,9-dihydroxy-2,10-diprenylpterocap... 9 25
Oestrogen receptor and Estrogen receptor beta Ligand 6-(4-hydr... 30 63
Abelson tyrosine-protein kinase 2 Inhibitor 3'',5''-dimethoxy-... 3 9
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 5 13
Coagulation factor X and Prothrombin Inhibitor 3-chlorophenyl ... 2 12
Arachidonate 15-lipoxygenase Inhibitor Hydrohalisulfate 1 Family 6 6
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 56
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 127
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Ellagi... 1 11
Tubulin beta chain Inhibitor Combretastatin Family 3 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 214
NAD(P)H dehydrogenase [quinone] 1 Inhibitor NSC-106547 Family 3 65
Leukotriene A-4 hydrolase Inhibitor 1-butoxy-4-phenoxybenzene ... 3 85
Arachidonate 15-lipoxygenase and Arachidonate 5-lipoxygenase I... 3 18
Platelet-derived growth factor receptor beta Ligand Bis(5-meth... 5 220
Tyrosine-protein phosphatase non-receptor type 1 Ligand Licoag... 9 32
Sodium/glucose cotransporter 2 Inhibitor Maackiain Family 1 5
Carbonic anhydrase 9 and Carbonic anhydrase 12 Inhibitor Ethox... 12 80
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 4-(1,... 3 31
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 160
Thyroid hormone receptor beta Ligand 2-hexylphenyl Acrylate Fa... 4 83
Cytosolic phospholipase A2 Inhibitor [6,3''']biflavone Family 5 5
Kappa-type opioid receptor Ligand Anisocoumarin H Family 3 5
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 37
Androgen receptor Ligand 2-methoxy-4-(o-tolyloxy)benzonitrile ... 5 12
Protein kinase C alpha type and Protein kinase C beta type Inh... 2 1
Protein kinase C alpha type Inhibitor Acetoside Family 5 39
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 2 12
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 5 8
MO15-related protein kinase Pfmrk Inhibitor WR-289012 Family 2 17
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 3-ben... 4 74
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Arachidonate 12-lipoxygenase, 12S-type and Arachidonate 15-lip... 2 1
Androgen receptor Ligand 2'-hydroxy-3-methoxy-biphenyl-4-carbo... 2 13
Protein kinase C gamma type and Protein kinase C alpha type In... 2 1
Cytochrome P450 3A4 Inhibitor (8r,8'r,9's)-5-methoxyclusin Family 6 20
Cytochrome P450 3A4 Inhibitor (-)-cubebininolide Family 4 28
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Interleukin-8 Inhibitor 2-(2-(2-fluorophenoxy)phenyl)acetic Ac... 2 4
Amine oxidase [flavin-containing] B Inhibitor (s)(+)-7-fluoro-... 11 11
NAD(P)H dehydrogenase [quinone] 1 Inhibitor Ethyl Bis(4-hydrox... 5 7
NAD(P)H dehydrogenase [quinone] 1 Inhibitor 4-hydroxy-3-(2-nap... 12 1
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 6-meth... 2 36
Amine oxidase [flavin-containing] B Inhibitor 3-(4-methoxyphen... 3 29
Amine oxidase [flavin-containing] B Inhibitor 7-fluoro-2-p-tol... 4 11
Cytochrome P450 2D6 Inhibitor 4-methylaminomethyl-7-methoxycou... 3 80
Tyrosine-protein phosphatase non-receptor type 1 and Neuramini... 10 2
Aromatase Inhibitor 3,4-bis(3,4-dimethoxyphenyl)furan-2(5h)-on... 4 86
Amine oxidase [flavin-containing] B Inhibitor 4-oxo-4h-chromen... 2 3
Beta-secretase 1 Inhibitor Eckol Family 6 40
Indoleamine 2,3-dioxygenase 1 Inhibitor 4-methoxybenzenemethan... 2 26
Amine oxidase [flavin-containing] B Inhibitor 8-bromo-6-methyl... 5 44
Cytochrome P450 3A4 Inhibitor Diethoxyflourescein Family 3 9
Heat shock cognate 71 kDa protein Inhibitor NSC-119913 Family 2 1
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 2-(3-c... 5 72
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Protein farnesyltransferase subunit beta Inhibitor Cylindrol A... 3 43
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 3 0
Tyrosinase Inhibitor 3-(2,4-dihydroxyphenyl)-propionic Acid Et... 3 8
Prostaglandin G/H synthase 1 Inhibitor 2-(2-methoxyphenyl)-1h-... 1 11
Tyrosinase Inhibitor 4-(6-hydroxynaphthalen-2-yl)benzene-1,3-d... 4 2
Tyrosinase Inhibitor Kazinol S Family 1 0
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
Tyrosinase Inhibitor 4-adamantyl Resorcinol Family 1 1
Androgen receptor Ligand Palodesangren E Family 12 43
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 3 27
Liver carboxylesterase 1 Inhibitor 2-methoxy-3,4-methylenediox... 4 26
Tyrosyl-DNA phosphodiesterase 1 and Microtubule-associated pro... 1 1
Sodium/glucose cotransporter 2 and Sodium/glucose cotransporte... 3 19
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 7
Alpha-1A adrenergic receptor and 5-hydroxytryptamine receptor ... 1 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand [(6aR... 1 0
Prelamin-A/C and Solute carrier organic anion transporter fami... 1 15
Estrogen receptor beta and Estrogen receptor ligand 3-fluoro-4... 6 42
D(4) dopamine receptor and D(3) dopamine receptor ligand 3-ben... 5 334
Cannabinoid receptor 1 ligand 6,6,9-trimethyl-3-(6-nitrohex-2-... 1 0
Peroxisome proliferator-activated receptor alpha and Peroxisom... 7 6
Endothelin-1 receptor ligand (2S)-2-(1,3-benzodioxol-5-yl)-4-m... 17 0
Arachidonate 5-lipoxygenase inhibitor 7-[[3-fluoro-5-[(1S,3S,5... 2 0
Vitamin D3 receptor ligand (3E,5E)-6-[3-[[3,4-bis(hydroxymethy... 2 4
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 2 0
5-hydroxytryptamine receptor 7 and Alpha-2C adrenergic recepto... 3 0
Estrogen receptor beta and Estrogen receptor ligand SureCN4017... 3 5
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 7 13
Carbonic anhydrase 2 and Carbonic anhydrase 5A, mitochondrial ... 4 5
Carbonic anhydrase 2 and Carbonic anhydrase 5A, mitochondrial ... 1 0
Carbonic anhydrase 2 and Carbonic anhydrase 5A, mitochondrial ... 3 5
Carbonic anhydrase 2 and Carbonic anhydrase 5A, mitochondrial ... 3 2
Vitamin D3 receptor ligand (1R,3S,5Z)-5-[(2E)-2-[(3aS,7aR)-1-[... 1 2
Estrogen receptor beta and Estrogen receptor ligand 7-bromo-3-... 1 0
Amine oxidase [flavin-containing] A inhibitor AGN-PC-00LZQK fa... 1 24
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 2 10
Low affinity sodium-glucose cotransporter and Sodium/glucose c... 1 0
Arachidonate 5-lipoxygenase inhibitor SureCN9727660 family 1 0
Arachidonate 5-lipoxygenase inhibitor SureCN9727677 family 1 2
Arachidonate 5-lipoxygenase inhibitor AGN-PC-073G1D family 1 0
Solute carrier family 22 member 6 and Histone-lysine N-methylt... 1 1
Neuropeptide Y receptor type 5 and Thioredoxin glutathione red... 13 6
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[2-... 1 0
Multidrug resistance protein 1 inhibitor CHEMBL1 family 2 0
Thioredoxin glutathione reductase and Beta-lactamase inhibitor... 1 0
Beta-lactamase inhibitor AGN-PC-0A9UJZ family 1 3
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 8
Cytochrome P450 1A1 and Cytochrome P450 1B1 inhibitor 1,2,4-tr... 1 0
Glutamate carboxypeptidase 2 inhibitor 2-phenylmethoxy-6-(2-su... 2 3
Cannabinoid receptor 1 and Monoglyceride lipase ligand 4-(4-ph... 4 4
Carbonic anhydrase 9 and Carbonic anhydrase 12 inhibitor 5,10-... 1 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 7
Tyrosine-protein phosphatase non-receptor type 1 and Tyrosine-... 2 1
Aldose reductase inhibitor 2-(7-chloro-2-oxochromen-4-yl)aceti... 1 0
Thyrotropin receptor and 3-hydroxyacyl-CoA dehydrogenase type-... 1 0
Vitamin K epoxide reductase complex subunit 1 inhibitor AGN-PC... 1 0
Androgen receptor ligand AGN-PC-00BPQ5 family 1 3
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 17
Receptor-type tyrosine-protein phosphatase C and Tyrosine-prot... 1 0
4-hydroxyphenylpyruvate dioxygenase inhibitor (3-hydroxyphenyl... 1 3
Epidermal growth factor receptor ligand NSC650565 family 1 0
Sugar Acids and Derivatives Metabolite 3-Methoxy-4-hydroxyphen... 1 6
Phenols and Derivatives Metabolite 3,4-Dihydroxyphenylglycol O... 1 1
Lignans and Norlignans Metabolite cis-Miyabenol C Family 3 0
Benzyloxycarbonyls Metabolite 4-Methoxybenzyl formate Family 1 7
Phenols and Derivatives Metabolite 2-Ethoxy-4-(4-methyl-1,3-di... 1 0
Phenylacetic Acid Derivatives Metabolite Guaicyl phenylacetate... 1 3
Benzofurans Metabolite (R)-Bitalin A Family 1 9
Phenols and Derivatives Metabolite 2-(Ethoxymethyl)phenol Family 1 14
Benzene and Substituted Derivatives Metabolite 1,3,5-Trimethox... 2 17
Coumarin NP Clausarin Family 1 0
Putative NP ZINC04043753 Family 8 6
diethylcarbamate NP 3-(2,5-dimethoxyphenyl)-4-methyl-2-oxo-2h-... 3 0
ahydropyrano[3,2-c]chromene NP ZINC04023039 Family 16 2
NP 4-(((3-(4-chlorophenyl)-2-methyl-4-oxo-4h-chromen-7-yl)oxy)... 14 0
NP 3-(4-methoxyphenoxy)-4-oxo-4h-chromen-7-yl 4-bromobenzoate ... 13 0
dimethylchromen-2-one NP 4-(chloromethyl)-6,7-dimethyl-2h-chro... 5 2
4-(7-((2-amino-3-phenylpropanoyl)oxy)-5-hydroxy-4-oxo-4H-chrom... 3 0
NP (z)-2-((2-methyl-2h-chromen-3-yl)methylene)-3-oxo-2,3-dihyd... 74 1
3-[7-[(4-bromo-2-fluorophenyl)methoxy]-4-methyl-2-oxochromen-3... 5 0
(4-methyl-2-oxochromen-7-yl) (2R)-2-amino-4-methylpentanoate N... 1 0
4-oxochromene-2-carboxylate NP Ethyl 3-(7-(2-(4-bromophenyl)-2... 10 1
2-(4-methoxyphenyl)-10,10-dimethyl-1,3,9-trioxaspiro[5.5]undec... 4 19
NP Ethyl 7-((2-chlorobenzoyl)oxy)-3-(2-methoxyphenyl)-4-oxo-4h... 37 1
orobenzoate NP 3-(2-methoxyphenyl)-2-methyl-4-oxo-4h-chromen-7... 22 0
4-(9H-xanthen-9-yl)-9H-xanthene NP 9h,9'h-4,9'-bixanthene Family 1 0
Putative NP ZINC00526277 Family 2 2
2-[(E)-3-hydroxy-3-(6-methyl-2,4-dioxopyran-3-ylidene)prop-1-e... 1 0
Putative NP ZINC02424323 Family 24 0
NP Agn-pc-05t67i Family 5 0
ethyl 4-[2-(hydroxyamino)-2-(2-hydroxy-4-oxocyclohexa-2,5-dien... 1 0
bromobenzoate NP ZINC11865066 Family 6 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00135659 DCL000196 Clinical Trial Drug Phenoxodiol
CFAMM00135824 DNC011168 Investigative Drug CATECHIN
CFAMM00136077 DNC010301 Investigative Drug 2-(4-methoxyphenyl)-4H-chromene-4-thione
CFAMM00136477 DNC008697 Investigative Drug 7-hydroxy-3-phenyl-2H-chromen-2-one
CFAMM00136993 DNC011220 Investigative Drug 7-Hydroxy-4-phenylcoumarin
CFAMM00136520 DNC006323 Investigative Drug 6-ethyl-4,7-dimethyl-6H-benzo[c]chromene-3,8-diol
CFAMM00136347 DNC014342 Investigative Drug CALOPOCARPIN
CFAMM00135710 DNC000103 Investigative Drug 7-hydroxycoumarin
CFAMM00136519 DNC006324 Investigative Drug 4,6,7-trimethyl-6H-benzo[c]chromene-3,8-diol
CFAMM00136346 DNC014345 Investigative Drug PHASEOLLIDIN
CFAMM00136529 DNC007120 Investigative Drug EPIGALLOCATECHIN
CFAMM00136518 DNC006325 Investigative Drug 4,6,10-trimethyl-6H-benzo[c]chromene-3,8-diol
CFAMM00136473 DNC010672 Investigative Drug Erybreadin C
CFAMM00136846 DNC013413 Investigative Drug AM-1715
CFAMM00136043 DNC014338 Investigative Drug DEMETHYLMEDICARPIN
CFAMM00136517 DNC006326 Investigative Drug 4,10-dimethyl-6H-benzo[c]chromene-3,8-diol
CFAMM00136483 DNC010879 Investigative Drug TUPICHINOL C
CFAMM00136370 DNC005489 Investigative Drug 3-(4-Hydroxy-phenyl)-4H-chromen-7-ol
CFAMM00136902 DNC010297 Investigative Drug 7-methoxy-2-p-tolyl-4H-chromene-4-thione
CFAMM00136516 DNC006327 Investigative Drug 4,7-dimethyl-6H-benzo[c]chromene-3,8-diol
CFAMM00136482 DNC010878 Investigative Drug BROUSSONIN A
CFAMM00136506 DNC008513 Investigative Drug CATECHOL
CFAMM00136188 DNC010064 Investigative Drug 7-(benzyloxy)-2H-chromen-2-one
CFAMM00136521 DNC006322 Investigative Drug 4,6,7,10-tetramethyl-6H-benzo[c]chromene-3,8-diol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21794 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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