CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Tyrosine-protein kinase SYK Inhibitor R788 Family
No. of Seeds 3 No. of Other Members 7
Family Centroid CFAMM00137681 Functional Category Clinical Trial Drug
Superfamily Tyrosine-protein kinase SYK Binder Superfamily
Class Class 850

Cousin Family NamesSeedsMembers
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 25 40
AP26113 family 16 90
Platelet-derived growth factor receptor beta and Platelet-deri... 2 19
Aurora kinase A and Aurora kinase B inhibitor AGN-PC-00EQPZ fa... 3 4
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
Glycogen synthase kinase-3 alpha and Casein kinase II subunit ... 1 16
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 10
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 1 3
Vascular endothelial growth factor receptor 3 and Platelet-der... 8 13
Proto-oncogene tyrosine-protein kinase Src and Vascular endoth... 7 3
ALK tyrosine kinase receptor and Insulin-like growth factor 1 ... 1 4
Epidermal growth factor receptor ligand N-[3-[7-[2-methoxy-4-(... 9 3
Protein-tyrosine kinase 2-beta and Focal adhesion kinase 1 inh... 3 6
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 7 16
Focal adhesion kinase 1 inhibitor AGN-PC-00AVK6 family 1 1
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 14 2
Lysine--tRNA ligase and Tyrosine-protein kinase Lyn inhibitor ... 1 0
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4463897 f... 3 2
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 9 2
Receptor tyrosine-protein kinase erbB-2 ligand SureCN3374869 f... 4 8
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
TGF-beta receptor type-1 ligand SureCN373216 family 3 14
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 2


External ID

Functional Category

Molecule Name

CFAMM00137682 CHEMBL475251 Bioactive 841290-80-0
CFAMM00137681 DCL000211 Clinical Trial Drug R788
CFAMM00137676 DNCL001657 Clinical Trial Drug Fostamatinib

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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