CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD135
Family Name Cathepsin K Inhibitor Relacatib Family
No. of Seeds 26 No. of Other Members 32
Family Centroid CFAMM00137724 Functional Category Clinical Trial Drug
Superfamily Cathepsin K and Neuronal acetylcholine receptor subunit alpha-4 Binder Superfamily
Class Class 918

Cousin Family NamesSeedsMembers
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Neuronal acetylcholine receptor subunit alpha-4 Ligand TC-5619... 3 61
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
5-hydroxytryptamine receptor 3A and Neuronal acetylcholine rec... 1 3
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 6 9
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 4 2
Fatty-acid amide hydrolase 1 inhibitor SureCN1471727 family 2 19
Cathepsin S and Cathepsin K inhibitor N-[(2S)-3-(1-methylcyclo... 2 0
Cytochrome P450 2C19 and Inositol monophosphatase 1 inhibitor ... 1 0
Histamine H3 receptor ligand SureCN2784306 family 5 3
Serine/threonine-protein kinase B-raf inhibitor furan-based co... 6 3
MAP kinase-activated protein kinase 2 inhibitor 4-[5-[[2-(2-me... 3 4
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(benzen... 3 1
Macrophage colony-stimulating factor 1 receptor ligand 5-cyano... 1 0
Cathepsin K and Cathepsin L1 inhibitor AC1NR9VX family 2 2
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-073HN6 f... 1 1
Collagenase 3 inhibitor SureCN1316041 family 4 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00137728 CHEMBL1807648 Bioactive N-[(2S)-3-cycloheptyl-1-[[(4S,7R)-7-methyl-3-oxo-1-pyridin-2-ylsulfonylazepan-4-yl]amino]-1-oxopropan-2-yl]furan-2-carboxamide
CFAMM00137721 CHEMBL1807645 Bioactive N-[(2S)-3-(cyclopenten-1-yl)-1-[[(4S,7R)-7-methyl-3-oxo-1-pyridin-2-ylsulfonylazepan-4-yl]amino]-1-oxopropan-2-yl]furan-2-carboxamide
CFAMM00137692 CHEMBL1807652 Bioactive N-[(2S)-3-(1-methylcyclohexyl)-1-[[(4S,7R)-7-methyl-3-oxo-1-pyridin-2-ylsulfonylazepan-4-yl]amino]-1-oxopropan-2-yl]furan-2-carboxamide
CFAMM00137749 CHEMBL1807699 Bioactive N-[(2S)-3-(4,4-dimethylcyclohexyl)-1-[[(4S,7R)-7-methyl-3-oxo-1-pyridin-2-ylsulfonylazepan-4-yl]amino]-1-oxopropan-2-yl]furan-2-carboxamide
CFAMM00137712 CHEMBL31381 Bioactive SureCN6923555
CFAMM00137727 CHEMBL203845 Bioactive Azepan-3-one compound 3
CFAMM00137748 CHEMBL31545 Bioactive ketone, 1
CFAMM00137708 CHEMBL474438 Bioactive N-[(2S)-4-fluoro-4-methyl-1-oxo-1-[[(4S)-3-oxo-1-pyridin-2-ylsulfonylazepan-4-yl]amino]pentan-2-yl]-1-benzofuran-2-carboxamide
CFAMM00137725 CHEMBL205172 Bioactive Azepan-3-one compound 7
CFAMM00137739 CHEMBL1807697 Bioactive N-[(2S)-4-cyclopentyl-1-[[(4S,7R)-7-methyl-3-oxo-1-pyridin-2-ylsulfonylazepan-4-yl]amino]-1-oxobutan-2-yl]furan-2-carboxamide
CFAMM00137754 CHEMBL203224 Bioactive Azepan-3-one compound 12
CFAMM00137745 CHEMBL377713 Bioactive Azepan-3-one compound 11
CFAMM00137695 CHEMBL202668 Bioactive Azepan-3-one compound 2
CFAMM00137753 CHEMBL31674 Bioactive N-[(2S)-4-methyl-1-oxo-1-[[(4R)-3-oxo-1-pyridin-2-ylsulfonylazepan-4-yl]amino]pentan-2-yl]-1-benzofuran-2-carboxamide
CFAMM00137730 CHEMBL202991 Bioactive 362507-64-0
CFAMM00137688 CHEMBL440574 Bioactive Azepan-3-one compound 9
CFAMM00137694 CHEMBL1807650 Bioactive N-[(2S)-4,4-dimethyl-1-[[(4S,7R)-7-methyl-3-oxo-1-pyridin-2-ylsulfonylazepan-4-yl]amino]-1-oxopentan-2-yl]furan-2-carboxamide
CFAMM00137723 CHEMBL1807647 Bioactive N-[(2S)-3-cyclohexyl-1-[[(4S,7R)-7-methyl-3-oxo-1-pyridin-2-ylsulfonylazepan-4-yl]amino]-1-oxopropan-2-yl]furan-2-carboxamide
CFAMM00137751 CHEMBL286364 Bioactive SB-357114
CFAMM00137715 CHEMBL194861 Bioactive N-[(2S)-3-naphthalen-2-yl-1-oxo-1-[[(4S)-3-oxo-1-pyridin-2-ylsulfonylazepan-4-yl]amino]propan-2-yl]-1-benzofuran-2-carboxamide
CFAMM00137729 CHEMBL1807649 Bioactive N-[(2S)-4-methyl-1-[[(4S,7R)-7-methyl-3-oxo-1-pyridin-2-ylsulfonylazepan-4-yl]amino]-1-oxopentan-2-yl]furan-2-carboxamide
CFAMM00137705 CHEMBL407633 Bioactive N-[(2S)-1-oxo-1-[[(4S)-3-oxo-1-pyridin-2-ylsulfonylazepan-4-yl]amino]-3-phenylpropan-2-yl]-1-benzofuran-2-carboxamide
CFAMM00137693 CHEMBL1807651 Bioactive N-[(2S)-3-(1-methylcyclopentyl)-1-[[(4S,7R)-7-methyl-3-oxo-1-pyridin-2-ylsulfonylazepan-4-yl]amino]-1-oxopropan-2-yl]furan-2-carboxamide
CFAMM00137722 CHEMBL1807646 Bioactive N-[(2S)-3-cyclopentyl-1-[[(4S,7R)-7-methyl-3-oxo-1-pyridin-2-ylsulfonylazepan-4-yl]amino]-1-oxopropan-2-yl]furan-2-carboxamide
CFAMM00137750 CHEMBL1807698 Bioactive N-[(2S)-3-(4-methylcyclohexyl)-1-[[(4S,7R)-7-methyl-3-oxo-1-pyridin-2-ylsulfonylazepan-4-yl]amino]-1-oxopropan-2-yl]furan-2-carboxamide
CFAMM00137724 DCL000214 Clinical Trial Drug Relacatib

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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