CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD140
Family Name Proteinase-activated receptor 1 Ligand SCH-530348 Family
No. of Seeds 20 No. of Other Members 215
Family Centroid CFAMM00138316 Functional Category Clinical Trial Drug with Natural Product
Superfamily 5-hydroxytryptamine receptor Ligand Metergolin Superfamily
Class Class 447

Cousin Family NamesSeedsMembers
Muscarinic acetylcholine receptor M4 Ligand Tropicamide Family 3 73
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243
Thromboxane A2 receptor Ligand Ridogrel Family 7 83
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand (s)-(+)-dimethindene Maleate Family 6 12
Prothrombin Inhibitor Ximelegatran Family 8 157
Prostaglandin E synthase Inhibitor L-655240 Family 3 46
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 5 23
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 3 5
Cathepsin K and Cathepsin S Inhibitor P2,p3 Ketoamide Derivati... 2 1
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 4 12
Acetylcholinesterase Inhibitor Lysicamine Family 2 8
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase inhibit... 2 24
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase inhibit... 4 8
Sodium-dependent serotonin transporter and Sodium-dependent do... 6 4
5-hydroxytryptamine receptor 2A and Alpha-1B adrenergic recept... 10 9
5-hydroxytryptamine receptor 2A and Alpha-1B adrenergic recept... 4 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 1
Sterol O-acyltransferase 1 inhibitor dodecyl 3-[2,6-di(propan-... 1 2
Pol polyprotein inhibitor (2S,4S,5S)-5-acetamido-6-cyclohexyl-... 3 3
Glucocorticoid receptor ligand 1,1,1-trifluoro-2-[(1-methyl-3,... 3 4
Proteinase-activated receptor 1 ligand (3R,3aR,4S,5R,6S,7aS)-5... 2 3
Proteinase-activated receptor 1 ligand (3R,3aR,4S,5R,6S,7aS)-5... 1 2
Prostaglandin D2 receptor 2 ligand SureCN317401 family 3 8
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 10 2
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor Sure... 2 6
G-protein coupled bile acid receptor 1 ligand 1-[4-[(1R,3E)-1-... 1 1
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 2
Thromboxane-A synthase inhibitor 7-[(2S,3R)-3-pyridin-3-yl-2-b... 1 1
Proteinase-activated receptor 1 ligand (3R,3aS,4S,4aR,8aS,9aR)... 1 11
5-hydroxytryptamine receptor 2A and Alpha-1B adrenergic recept... 1 0
Proteinase-activated receptor 1 ligand ethyl N-[(1R,3aR,4aR,6R... 1 4
Proteinase-activated receptor 1 ligand (3R,3aR,4S,5R,6S,7aS)-5... 1 0
Proteinase-activated receptor 1 ligand (3R,3aS,4S,4aR,8aS,9aR)... 1 1
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor Sure... 1 1
Potassium voltage-gated channel subfamily A member 5 ligand AG... 4 0
Fatty-acid amide hydrolase 1 inhibitor [(1R)-1-[(3S)-2-oxo-1-p... 1 2
Putative NP ZINC03999795 Family 18 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00138185 CHEMBL244299 Bioactive (1R,3aR,4aS,8aS,9S,9aS)-6-(cyclopropanecarbonyl)-9-[(E)-2-[5-(2-fluorophenyl)pyridin-2-yl]ethenyl]-1-methyl-1,3a,4,4a,5,7,8,8a,9,9a-decahydrofuro[3,4-g]isoquinolin-3-one
CFAMM00138152 CHEMBL244105 Bioactive ethyl (1R,3aR,4aS,8aS,9S,9aS)-9-[(E)-2-[5-(2-fluorophenyl)pyridin-2-yl]ethenyl]-1-methyl-3-oxo-1,3a,4,4a,5,7,8,8a,9,9a-decahydrofuro[3,4-g]isoquinoline-6-carboxylate
CFAMM00138264 CHEMBL493792 Bioactive N-[(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-1-methyl-3-oxo-3a,4,4a,5,6,7,8,8a,9,9a-decahydro-1H-benzo[f][2]benzofuran-6-yl]propanamide
CFAMM00138164 CHEMBL390630 Bioactive ethyl (1R,3aR,4aS,8aS,9S,9aS)-9-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-1-methyl-3-oxo-1,3a,4,4a,5,7,8,8a,9,9a-decahydrofuro[3,4-g]isoquinoline-6-carboxylate
CFAMM00138290 CHEMBL391098 Bioactive (3aS,9R,9aR)-5,6-difluoro-9-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-3a,4,9,9a-tetrahydro-1H-benzo[f][2]benzofuran-3-one
CFAMM00138170 CHEMBL494618 Bioactive SureCN8055776
CFAMM00138210 CHEMBL493633 Bioactive SureCN13324653
CFAMM00138150 CHEMBL269006 Bioactive (3aR,4R,9aS)-6-fluoro-4-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-3a,4,9,9a-tetrahydro-3H-benzo[f][2]benzofuran-1-one
CFAMM00138223 CHEMBL453277 Bioactive SureCN13324633
CFAMM00138309 CHEMBL458264 Bioactive ethyl N-[(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(E)-2-[5-(3,5-difluorophenyl)pyridin-2-yl]ethenyl]-1-methyl-3-oxo-3a,4,4a,5,6,7,8,8a,9,9a-decahydro-1H-benzo[f][2]benzofuran-6-yl]carbamate
CFAMM00138322 CHEMBL500551 Bioactive SureCN13324646
CFAMM00138289 CHEMBL493983 Bioactive SureCN14203468
CFAMM00138242 CHEMBL2012489 Bioactive (3R,3aS,4S,5R,6S,7aR)-5-ethyl-3,6-dimethyl-4-[(E)-2-(5-phenylpyridin-2-yl)ethenyl]-3a,4,5,6,7,7a-hexahydro-3H-2-benzofuran-1-one
CFAMM00138209 CHEMBL493632 Bioactive SureCN13324657
CFAMM00138268 CHEMBL523854 Bioactive 1-[(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-1-methyl-3-oxo-3a,4,4a,5,6,7,8,8a,9,9a-decahydro-1H-benzo[f][2]benzofuran-6-yl]-3-ethylurea
CFAMM00138300 CHEMBL447996 Bioactive SureCN14360111
CFAMM00138140 CHEMBL232955 Bioactive (3aS,9R,9aR)-6-fluoro-9-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-3a,4,9,9a-tetrahydro-1H-benzo[f][2]benzofuran-3-one
CFAMM00138325 CHEMBL234397 Bioactive (3aR,4R,9aS)-4-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-3a,4,9,9a-tetrahydro-3H-benzo[f][2]benzofuran-1-one
CFAMM00138316 DCL000225 Clinical Trial Drug SCH-530348
CFAMM00138299 DNC005792 Investigative Drug SCH-205831

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21767 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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