CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD148
Family Name NAD-dependent protein deacetylase sirtuin-1 Inhibitor SRT501 Family
No. of Seeds 19 No. of Other Members 88
Family Centroid CFAMM00138821 Functional Category Clinical Trial Drug with Human Metabolite & Natural Product
Superfamily NAD-dependent protein deacetylase sirtuin-1 Inhibitor SRT501 Superfamily
Class Class 785

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand catecholamine Dopamine family 9 170
Prostaglandin G/H synthase 2 Inhibitor Diflunisal Family 7 421
Cannabinoid receptor 1 Ligand Marinol Family 32 454
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Fatty-acid amide hydrolase 1 Inhibitor Propofol Family 5 428
Estrogen receptor beta Ligand Conjugated Estrogens Family 12 210
Tyrosinase Inhibitor Monobenzone Family 6 197
Oestrogen receptor ligand steroid Estradiol Family 18 147
Oestrogen receptor ligand Dienestrol Family 35 440
Oestrogen receptor Ligand Chlorotrianisene Family 2 102
D-alanyl-D-alanine carboxypeptidase Inhibitor B-lactams Family 59 1364
Aldehyde oxidase Inhibitor Isovanillin Family 6 429
Noradrenergic re-uptake Inhibitor Desvenalfaxine Succinate Family 2 4
Ipriflavone family 62 2480
Agrimophol family 10 22
Salicin family 5 629
Oestrogen receptor ligand Fosfestrol Family 1 20
Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... 21 79
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
Steryl-sulfatase Inhibitor Stx 64 Family 7 160
Translocator protein Inhibitor Dextofisopam Family 3 250
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Oxi4503 family 4 27
TS-071 family 8 36
Glycoprotein IIb/IIIa receptor Ligand Accutin Family 4 24
Arachidonate 5-lipoxygenase Inhibitor Caffeic Acid Family 3 32
Endothelin-1 receptor Ligand PD156707 Family 41 211
Bile acid receptor Ligand SR-45023A (apomine) Family 3 34
Macrophage migration inhibitory factor and Prothrombin Inhibit... 2 49
Estrogen receptor beta Ligand 1-chloro-6-(4-hydroxyphenyl)-2-n... 12 23
5-hydroxytryptamine receptor 2A Ligand Phenethylamine Family 3 25
Arachidonate 15-lipoxygenase Inhibitor Isoscopoletin Family 5 98
Platelet-activating factor receptor Ligand L-652731 Family 5 116
Steryl-sulfatase Inhibitor Sulfamic Acid 4-(3-methoxy-benzoyl)... 5 24
Glucocorticoid receptor Ligand 1-methoxy-6-phenyl-6h-benzo[c]c... 2 22
Tyrosine-protein kinase Lck Inhibitor 2-(3,4,5-trihydroxy-benz... 2 6
Epidermal growth factor receptor Ligand AG-538 Family 5 11
Oestrogen receptor and Estrogen receptor beta Ligand 6-(4-hydr... 30 63
Abelson tyrosine-protein kinase 2 Inhibitor 3'',5''-dimethoxy-... 3 9
Oestrogen receptor and Estrogen receptor beta Ligand 1-bromo-6... 3 4
Arachidonate 15-lipoxygenase Inhibitor Hydrohalisulfate 1 Family 6 6
4-aminobutyrate aminotransferase, mitochondrial and Succinate-... 4 22
Tubulin beta chain Inhibitor Combretastatin Family 3 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 214
Arachidonate 15-lipoxygenase and Arachidonate 5-lipoxygenase I... 3 18
Tyrosine-protein phosphatase non-receptor type 1 Ligand Licoag... 9 32
Kinesin-like protein KIF11 Inhibitor 4'-(trifluoromethyl)-4-bi... 2 4
Carbonic anhydrase 9 and Carbonic anhydrase 12 Inhibitor Ethox... 12 80
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 4-(1,... 3 31
Kappa-type opioid receptor Ligand Anisocoumarin H Family 3 5
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 37
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-(6-hydroxy-2-nap... 7 9
Carbonic anhydrase 2 and Carbonic anhydrase 12 Inhibitor Resor... 2 7
Androgen receptor Ligand 2-methoxy-4-(o-tolyloxy)benzonitrile ... 5 12
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 2 12
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 5 8
Arachidonate 12-lipoxygenase, 12S-type and Arachidonate 15-lip... 2 1
Androgen receptor Ligand 2'-hydroxy-3-methoxy-biphenyl-4-carbo... 2 13
Cytochrome P450 3A4 Inhibitor (8r,8'r,9's)-5-methoxyclusin Family 6 20
Cytochrome P450 3A4 Inhibitor (-)-cubebininolide Family 4 28
NAD(P)H dehydrogenase [quinone] 1 Inhibitor Ethyl Bis(4-hydrox... 5 7
Indoleamine 2,3-dioxygenase 1 Inhibitor Naphthalene-1,4-diol F... 2 4
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor P-coum... 1 1
Tyrosine-protein phosphatase non-receptor type 1 and Neuramini... 10 2
Beta-secretase 1 Inhibitor Eckol Family 6 40
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Protein farnesyltransferase subunit beta Inhibitor Cylindrol A... 3 43
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 1 2
Tyrosinase Inhibitor 3-(2,4-dihydroxyphenyl)-propionic Acid Et... 3 8
Prostaglandin G/H synthase 1 Inhibitor 2-(2-methoxyphenyl)-1h-... 1 11
Tyrosinase Inhibitor 4-(6-hydroxynaphthalen-2-yl)benzene-1,3-d... 4 2
Tyrosinase Inhibitor Kazinol S Family 1 0
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
Tyrosinase Inhibitor 4-adamantyl Resorcinol Family 1 1
Androgen receptor Ligand Palodesangren E Family 12 43
Liver carboxylesterase 1 Inhibitor 2-methoxy-3,4-methylenediox... 4 26
Sodium/glucose cotransporter 2 and Sodium/glucose cotransporte... 3 19
Estrogen receptor and Estrogen receptor beta ligand 4-[(E)-4-(... 1 2
Vitamin D3 receptor ligand (3E,5E)-6-[3-[[3,4-bis(hydroxymethy... 2 4
Estrogen receptor beta and Estrogen receptor ligand (4Z)-2-flu... 2 0
Luciferin 4-monooxygenase inhibitor (6Z)-6-[(5R)-5-benzyl-1,2-... 2 0
5-hydroxytryptamine receptor 7 and Alpha-2C adrenergic recepto... 3 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 14
Carbonic anhydrase 2 and Carbonic anhydrase 5A, mitochondrial ... 4 5
Carbonic anhydrase 2 and Carbonic anhydrase 5A, mitochondrial ... 1 0
Estrogen receptor and Estrogen receptor beta ligand 3-[(E)-4-(... 1 3
Androgen receptor and Progesterone receptor ligand diarylpheno... 1 1
Cellular tumor antigen p53 and Epidermal growth factor recepto... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 4 0
Lethal factor and Nuclear receptor ROR-gamma ligand CHEMBL1559... 1 2
Monoglyceride lipase inhibitor 7-(2-hydroxyphenyl)heptane-1-su... 1 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 5-(2-... 3 0
3-oxoacyl-[acyl-carrier-protein] synthase 3 inhibitor BAS 0067... 1 0
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 1 0
G2/mitotic-specific cyclin-B1 and Cyclin-dependent kinase 1 in... 2 8
Beta-lactamase inhibitor AGN-PC-0A9UJZ family 1 3
Carbonic anhydrase 2 and Carbonic anhydrase 1 inhibitor propan... 3 5
DNA polymerase beta and Thioredoxin glutathione reductase inhi... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 1-[3,... 4 0
Cytochrome P450 1A1 and Cytochrome P450 1B1 inhibitor 1,2,4-tr... 1 0
Carbonic anhydrase 12 and Carbonic anhydrase 9 inhibitor 2,2-d... 1 0
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 i... 1 3
Eukaryotic elongation factor 2 kinase and Proto-oncogene tyros... 1 1
Retinoic acid receptor beta ligand Adarotene family 1 0
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 i... 1 3
Epidermal growth factor receptor ligand NSC650565 family 1 0
Phenols and Derivatives Metabolite 3,4-Dihydroxyphenylglycol O... 1 1
Phenols and Derivatives Metabolite 2-Chloro-1,3-dimethoxy-5-me... 1 3
Acenes Metabolite 2-Methyl-1,4-naphthalenediol bis(dihydrogen ... 2 2
Benzyloxycarbonyls Metabolite 4-Methoxybenzyl formate Family 1 7
Phenols and Derivatives Metabolite 2-Ethoxy-4-(4-methyl-1,3-di... 1 0
Phenols and Derivatives Metabolite 2-(Ethoxymethyl)phenol Family 1 14
Benzene and Substituted Derivatives Metabolite 1,3,5-Trimethox... 2 17
[(E)-3-carboxy-2-(5-methyl-2-oxidophenyl)prop-2-enyl]-(2-pheny... 3 0
2-(4-methoxyphenyl)-10,10-dimethyl-1,3,9-trioxaspiro[5.5]undec... 4 19
NP Agn-pc-05t67i Family 5 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00138813 CHEMBL87333 Bioactive cis-resveratrol
CFAMM00138821 DCL000234 Clinical Trial Drug SRT501
CFAMM00138871 DNC011297 Investigative Drug NSC-65069
CFAMM00138895 DNC013696 Investigative Drug 4-hexyl resorcinol
CFAMM00138910 DNC013716 Investigative Drug N-butylresorcinol
CFAMM00138939 DNC003300 Investigative Drug Resveratrol
CFAMM00138876 DNC007075 Investigative Drug 2,4,3',5'-tetrahydroxybibenzyl
CFAMM00138867 DNC011023 Investigative Drug Resveratrol Potassium3-Sulfate
CFAMM00138916 DNC011307 Investigative Drug NSC-115890
CFAMM00138875 DNC007074 Investigative Drug OXYRESVERATROL
CFAMM00138923 DNC001123 Investigative Drug Piceatannol
CFAMM00138905 DNC006561 Investigative Drug (E)-4-(3,5-dimethoxystyryl)phenol
CFAMM00138851 DNC013902 Investigative Drug 5-{8(Z),-pentadecenyl}resorcinol
CFAMM00138866 DNC011022 Investigative Drug Resveratrol Potassium4,-Sulfate
CFAMM00138850 DNC013903 Investigative Drug 5-{8(Z),11(Z)-pentadecadienyl}resorcinol
CFAMM00138864 DNC006515 Investigative Drug 1,6-Bis(4'-hydroxyphenyl)-hexa-1,3,5-triene
CFAMM00138914 DNC013969 Investigative Drug 4,4'-(ethane-1,2-diyl)dibenzene-1,3-diol
CFAMM00138849 DNC013901 Investigative Drug 5-{8(Z),11(Z),14-pentadecatrienyl}resorcinol
CFAMM00138862 DNC003145 Investigative Drug 5-[2-(4-hydroxyphenyl)ethyl]benzene-1,3-diol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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