CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD151
Family Name Steryl-sulfatase Inhibitor Stx 64 Family
No. of Seeds 7 No. of Other Members 160
Family Centroid CFAMM00139095 Functional Category Clinical Trial Drug with Human Metabolite & Natural Product
Superfamily Steryl-sulfatase Inhibitor Stx 64 Superfamily
Class Class 164

Cousin Family NamesSeedsMembers
Thyroid hormone receptor alpha ligand thyroid hormone analog L... 10 61
Prostaglandin G/H synthase 2 Inhibitor Diflunisal Family 7 421
Cannabinoid receptor 1 Ligand Marinol Family 32 454
Cyclooxygenase Inhibitor Fenoprofen Family 4 1077
Prostaglandin G/H synthase 1 Inhibitor Salicyclic Acid Family 3 39
Cyclooxygenase inhibitor salicylate derivative Aspirin family 3 234
Prostaglandin G/H synthase 2 Inhibitor Nabumetone Family 4 267
Signal transducer and activator of transcription 3 Inhibitor A... 5 249
Vitamin K epoxide reductase complex subunit 1 Inhibitor Warfar... 9 508
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor Mycophenola... 4 353
Heat shock protein 90, putative Inhibitor Cromoglicate Family 14 2827
DNA Binder Methoxsalen Family 10 1638
Muscarinic acetylcholine receptor Ligand Flavoxate Family 9 350
Vitamin K-dependent gamma-carboxylase Inhibitor Anisindione Fa... 3 243
D-alanyl-D-alanine carboxypeptidase Inhibitor B-lactams Family 59 1364
Aldehyde oxidase Inhibitor Isovanillin Family 6 429
Hidrosmin family 14 61
Ipriflavone family 62 2480
Rotenone family 16 107
taste receptor Ligand Cynarin Family 6 124
Agrimophol family 10 22
Salicin family 5 629
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
NAD-dependent protein deacetylase sirtuin-1 Inhibitor SRT501 F... 19 88
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Oxi4503 family 4 27
Free fatty acid receptor 1 Ligand TAK-875 Family 2 54
Interleukin-1 beta Inhibitor Diacerein Family 3 77
Serine protease Inhibitor Gabexate Family 1 3
Integrase Inhibitor L-708,906 Family 1 8
Endothelin-1 receptor Ligand PD156707 Family 41 211
Estrogen receptor beta Ligand 2-(4-hydroxy-phenyl)benzofuran-5... 5 82
Proto-oncogene tyrosine-protein kinase Src Inhibitor Malonic A... 1 34
Phospholipase A2 Inhibitor P-anisic Acid Family 2 178
Peroxisome proliferator-activated receptor gamma Ligand (2s)-2... 10 126
Arachidonate 15-lipoxygenase Inhibitor Isoscopoletin Family 5 98
Platelet-activating factor receptor Ligand L-652731 Family 5 116
Steryl-sulfatase Inhibitor 4-sulfamoyloxy-benzoic Acid Hexyl E... 11 1
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 Ligand... 4 26
Steryl-sulfatase Inhibitor Sulfamic Acid 4-(3-methoxy-benzoyl)... 5 24
Glucocorticoid receptor Ligand 1-methoxy-6-phenyl-6h-benzo[c]c... 2 22
Leukotriene B4 receptor 1 Ligand SC-51146 Family 6 315
Steryl-sulfatase Inhibitor Sulfamic Acid 2-nonyl-4-oxo-4h-chro... 4 68
DNA-dependent protein kinase catalytic subunit Inhibitor 7-pro... 5 49
Acetylcholinesterase and Cholinesterase Inhibitor 3-[7-(benzyl... 22 303
Phospholipase A2 Inhibitor 3,9-dihydroxy-2,10-diprenylpterocap... 9 25
Abelson tyrosine-protein kinase 2 Inhibitor 3'',5''-dimethoxy-... 3 9
Coagulation factor X and Prothrombin Inhibitor 3-chlorophenyl ... 2 12
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 56
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 3
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 127
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Ellagi... 1 11
Platelet-derived growth factor receptor beta Ligand Bis(5-meth... 5 220
Tyrosine-protein phosphatase non-receptor type 1 Ligand Licoag... 9 32
Carbonic anhydrase 9 and Carbonic anhydrase 12 Inhibitor Ethox... 12 80
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 160
Thyroid hormone receptor beta Ligand 2-hexylphenyl Acrylate Fa... 4 83
NAD(P)H dehydrogenase [quinone] 1 Inhibitor 4-amino-2h-chromen... 2 3
Cytosolic phospholipase A2 Inhibitor [6,3''']biflavone Family 5 5
Kappa-type opioid receptor Ligand Anisocoumarin H Family 3 5
Androgen receptor Ligand 2-methoxy-4-(o-tolyloxy)benzonitrile ... 5 12
MO15-related protein kinase Pfmrk Inhibitor WR-289012 Family 2 17
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 3-ben... 4 74
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Squalene monooxygenase Inhibitor Octyl_gallate Family 5 5
Protein kinase C gamma type and Protein kinase C alpha type In... 2 1
Cytochrome P450 3A4 Inhibitor (-)-cubebininolide Family 4 28
Interleukin-8 Inhibitor 2-(2-(2-fluorophenoxy)phenyl)acetic Ac... 2 4
Amine oxidase [flavin-containing] B Inhibitor (s)(+)-7-fluoro-... 11 11
Aromatase Inhibitor NSC-122427 Family 1 0
NAD(P)H dehydrogenase [quinone] 1 Inhibitor Ethyl Bis(4-hydrox... 5 7
NAD(P)H dehydrogenase [quinone] 1 Inhibitor 4-hydroxy-3-(2-nap... 12 1
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 6-meth... 2 36
Amine oxidase [flavin-containing] B Inhibitor 3-(4-methoxyphen... 3 29
Cytochrome P450 2D6 Inhibitor 4-methylaminomethyl-7-methoxycou... 3 80
Tyrosine-protein phosphatase non-receptor type 1 and Neuramini... 10 2
Aromatase Inhibitor 3,4-bis(3,4-dimethoxyphenyl)furan-2(5h)-on... 4 86
Amine oxidase [flavin-containing] B Inhibitor 4-oxo-4h-chromen... 2 3
Amine oxidase [flavin-containing] B Inhibitor 8-bromo-6-methyl... 5 44
Cytochrome P450 3A4 Inhibitor Diethoxyflourescein Family 3 9
Heat shock cognate 71 kDa protein Inhibitor NSC-119913 Family 2 1
Prostaglandin G/H synthase 1 Inhibitor Acetic Acid 2-heptylsel... 1 14
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 2-(3-c... 5 72
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 2-(3-b... 6 21
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Protein farnesyltransferase subunit beta Inhibitor Cylindrol A... 3 43
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 3 0
Tyrosinase Inhibitor 3-(2,4-dihydroxyphenyl)-propionic Acid Et... 3 8
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
Androgen receptor Ligand Palodesangren E Family 12 43
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 3 27
Liver carboxylesterase 1 Inhibitor 2-methoxy-3,4-methylenediox... 4 26
Tyrosyl-DNA phosphodiesterase 1 and Microtubule-associated pro... 1 1
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 7
Carbonic anhydrase 2 inhibitor (2-sulfamoyl-1-benzofuran-6-yl)... 2 8
Retinoic acid receptor RXR-alpha and Peroxisome proliferator-a... 3 17
Peroxisome proliferator-activated receptor alpha and Peroxisom... 7 6
Endothelin-1 receptor ligand (2S)-2-(1,3-benzodioxol-5-yl)-4-m... 17 0
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 2 0
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 7 13
Carbonic anhydrase 2 and Carbonic anhydrase 5A, mitochondrial ... 4 5
Carbonic anhydrase 2 and Carbonic anhydrase 5A, mitochondrial ... 3 5
Carbonic anhydrase 2 and Carbonic anhydrase 5A, mitochondrial ... 3 2
Protein kinase C beta type and Protein kinase C eta type inhib... 1 0
Estrogen receptor beta and Estrogen receptor ligand 7-bromo-3-... 1 0
Amine oxidase [flavin-containing] A inhibitor AGN-PC-00LZQK fa... 1 24
NAD(P)H dehydrogenase [quinone] 1 inhibitor AGN-PC-0AKS1I family 1 0
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 2 10
Reverse transcriptase/RNaseH inhibitor AC1L9WPU family 1 1
Acetylcholinesterase inhibitor 5,7-Dimethoxy-2-methyl-indan-1-... 1 0
Protein kinase C alpha type inhibitor [(1R)-4-dodecoxy-1-(hydr... 1 18
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase and Prelamin... 1 0
Carbonic anhydrase 2 and Carbonic anhydrase 1 inhibitor (4-met... 1 1
Sodium-dependent serotonin transporter and Sodium-dependent do... 3 78
Neuropeptide Y receptor type 5 and Thioredoxin glutathione red... 13 6
Multidrug resistance protein 1 inhibitor CHEMBL1 family 2 0
Putative fructose-1,6-bisphosphate aldolase and Retinal dehydr... 1 0
Thioredoxin glutathione reductase and Beta-lactamase inhibitor... 1 0
Survival motor neuron protein and Prelamin-A/C inhibitor CHEMB... 2 32
Cytochrome P450 3A4 inhibitor 4-[(2E)-6-[(E)-3-hydroxy-2,6-dim... 3 2
Carbonic anhydrase 2 and Carbonic anhydrase 1 inhibitor propan... 3 5
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 8
Reverse transcriptase/RNaseH inhibitor AC1O5CPP family 1 5
Glutamate carboxypeptidase 2 inhibitor 2-phenylmethoxy-6-(2-su... 2 3
Thyroid hormone receptor beta and Thyroid hormone receptor alp... 1 1
Carbonic anhydrase 9 and Carbonic anhydrase 12 inhibitor 5,10-... 1 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 7
Amine oxidase [flavin-containing] A inhibitor AGN-PC-02ON4B fa... 1 7
Cannabinoid receptor 1 and Cytochrome P450 3A4 ligand LY320135... 1 0
Cholesteryl ester transfer protein inhibitor [8-[(1S)-1-hydrox... 1 0
Vitamin K epoxide reductase complex subunit 1 inhibitor AGN-PC... 1 0
Prelamin-A/C and Inositol monophosphatase 1 inhibitor MLS00053... 1 1
Benzyloxycarbonyls Metabolite 4-Methoxybenzyl formate Family 1 7
Phenylacetic Acid Derivatives Metabolite Guaicyl phenylacetate... 1 3
Benzofurans Metabolite (R)-Bitalin A Family 1 9
Putative NP ZINC31165975 Family 4 0
Coumarin NP Clausarin Family 1 0
Putative NP ZINC31158464 Family 3 5
NP (z)-2-(2,3-dimethoxybenzylidene)-3-oxo-2,3-dihydrobenzofura... 9 0
NP (z)-2-(4-isopropylbenzylidene)-3-oxo-2,3-dihydrobenzofuran-... 16 0
Putative NP ZINC04043753 Family 8 6
NP 3-(4-chlorophenyl)-4,9-dimethyl-7h-furo[2,3-f]chromen-7-one... 18 0
NP 6-(4-ethoxyphenyl)-1,3-dimethyl-4-oxo-4h-cyclohepta[c]furan... 13 3
4H-1,3-benzodioxine-6-carboxylate NP ZINC07952017 Family 2 2
diethylcarbamate NP 3-(2,5-dimethoxyphenyl)-4-methyl-2-oxo-2h-... 3 0
NP Ethyl 3-(4-bromophenyl)-7-((methylsulfonyl)oxy)-4-oxo-4h-ch... 9 1
NP 2-((3-(3,4-dihydro-2h-benzo[b][1,4]dioxepin-7-yl)-6-ethyl-4... 10 0
2-amino-3-methylpentanoate NP 2-((3-(4-fluorophenoxy)-4-oxo-4h... 13 2
NP 4-(((3-(4-chlorophenyl)-2-methyl-4-oxo-4h-chromen-7-yl)oxy)... 14 0
NP 4-(chloromethyl)-6-methoxy-2h-chromen-2-one Family 4 2
2-(2-methoxyphenyl)-5-oxooxolane-3-carboxylate NP ZINC00132596... 4 2
NP 2,2,11,12-tetramethyl-3,4,8,9-tetrahydro-2h-cyclopenta[c]fu... 3 1
NP 3-(4-methoxyphenoxy)-4-oxo-4h-chromen-7-yl 4-bromobenzoate ... 13 0
2-methyl-2H-chromene-3-carbaldehyde NP 2-methyl-2h-chromene-3-... 2 1
NP (z)-6-((4-bromobenzyl)oxy)-2-(3,4-dimethoxybenzylidene)benz... 13 2
dimethylchromen-2-one NP 4-(chloromethyl)-6,7-dimethyl-2h-chro... 5 2
NP (z)-2-((2-methyl-2h-chromen-3-yl)methylene)-3-oxo-2,3-dihyd... 74 1
3-[7-[(4-bromo-2-fluorophenyl)methoxy]-4-methyl-2-oxochromen-3... 5 0
Putative NP ZINC32123984 Family 2 2
(4-methyl-2-oxochromen-7-yl) (2R)-2-amino-4-methylpentanoate N... 1 0
1-benzofuran-3-one NP (z)-2-(4-chlorobenzylidene)-3-oxo-2,3-di... 27 0
benzenesulfonate NP (z)-3-oxo-2-(3,4,5-trimethoxybenzylidene)-... 26 0
NP (2r,3r,4s,5r,6s)-2-(acetoxymethyl)-6-(2-propionylphenoxy)te... 2 3
4-oxochromene-2-carboxylate NP Ethyl 3-(7-(2-(4-bromophenyl)-2... 10 1
NP Ethyl 7-((2-chlorobenzoyl)oxy)-3-(2-methoxyphenyl)-4-oxo-4h... 37 1
orobenzoate NP 3-(2-methoxyphenyl)-2-methyl-4-oxo-4h-chromen-7... 22 0
Putative NP ZINC09486076 Family 56 0
Putative NP ZINC09305195 Family 19 0
1-benzofuran-3-one NP ZINC02367988 Family 9 0
1-benzofuran-3-one NP ZINC02423517 Family 24 0
benzenesulfonate NP ZINC09051160 Family 47 2
Putative NP ZINC02424323 Family 24 0
2-(trifluoromethyl)chromen-4-one NP ZINC01929476 Family 25 0
1-benzofuran-3-one NP ZINC02424004 Family 22 0
Putative NP ZINC05219435 Family 4 0
ethyl 4-[2-(hydroxyamino)-2-(2-hydroxy-4-oxocyclohexa-2,5-dien... 1 0
Putative NP ZINC01135787 Family 3 0
NP 7-[(4-bromobenzyl)oxy]-3-(2-methoxyphenyl)-2-(trifluorometh... 7 0
Putative NP ZINC09517236 Family 5 0
bromobenzoate NP ZINC11865066 Family 6 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00139095 DCL000238 Clinical Trial Drug STX 64
CFAMM00139122 DNC011331 Investigative Drug 7-methoxy-8-propionyl-2H-chromen-2-one
CFAMM00139223 DNC011340 Investigative Drug 8-acetyl-7-methoxy-2H-chromen-2-one
CFAMM00139240 DNC013874 Investigative Drug 3-Benzyl-5-methoxychromen-2-one
CFAMM00139125 DNC010060 Investigative Drug HERNIARIN
CFAMM00139124 DNC010066 Investigative Drug 7-methoxy-2-oxo-2H-chromene-4-carboxylic acid
CFAMM00139154 DNC005935 Investigative Drug 4-methyl-2-oxo-2H-chromen-7-yl sulfamate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21785 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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