CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD16
Family Name Transient receptor potential cation channel subfamily V member 1 Ligand A-425619 Family
No. of Seeds 15 No. of Other Members 158
Family Centroid CFAMM00127565 Functional Category Clinical Trial Drug with Natural Product
Superfamily Transient receptor potential cation channel subfamily V member 1 Ligand A-425619 Superfamily
Class Class 825

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B ligand triptan Almotriptan Family 8 438
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
D(2) dopamine receptor ligand ergot alkaloid Cabergoline Family 5 74
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Acetylcholinesterase Inhibitor Tacrine Family 12 515
Solute carrier family 12 member 1 Inhibitor Torasemide Family 13 75
D(2) dopamine receptor Ligand Sertindole Family 3 173
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Prothrombin Inhibitor Ximelegatran Family 8 157
Transient receptor potential cation channel subfamily V member... 16 295
Transient receptor potential cation channel subfamily V member... 15 457
Neuromedin-K receptor Ligand SB222200 Family 17 235
Transient receptor potential cation channel subfamily V member... 6 66
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
Reverse transcriptase Inhibitor Dapivirine Family 5 72
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
Amg 423 family 7 47
ABC294640 family 5 75
Neuropeptide Y receptor type 5 Ligand Npy5ra-972 Family 6 29
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Lethal factor Inhibitor GM6001 Family 50 435
XL-888 family 16 85
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Class II cytokine receptor Ligand IL-10 Family 7 45
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
Lethal factor Inhibitor N,n'-bis(4-amino-2-methylquinolin-6-yl... 2 11
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 3 15
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 19
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 22
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Histone deacetylase 6 Inhibitor N-(quinolin-3-yl)-6-(sulfamoyl... 4 8
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
Cholecystokinin receptor type A Ligand L-708474 Family 14 82
DNA-dependent protein kinase catalytic subunit Inhibitor 2-mor... 2 6
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-(3-cyano-... 2 4
Transient receptor potential cation channel subfamily V member... 6 23
Trypsin Inhibitor 1-benzyl-1h-indole-5-carboxamidine Family 4 3
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Transient receptor potential cation channel subfamily V member... 2 26
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Urotensin-2 receptor Ligand Palosuran Family 4 4
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 9
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 6
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Protein kinase C alpha type Inhibitor Dequalinium Analogue Family 1 10
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Transient receptor potential cation channel subfamily V member... 3 1
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 1 13
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhib... 1 1
Epidermal growth factor receptor ligand AGN-PC-07Q1HU family 4 17
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 2
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 14 8
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
Coagulation factor X and Trypsin-1 inhibitor AGN-PC-080PKK family 1 0
Neuropeptide Y receptor type 5 ligand 2-[4-(benzenesulfonamido... 2 27
Histamine H3 receptor ligand 1-[1-[1-[(2-aminopyridin-4-yl)met... 16 9
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 1 0
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 1 inhibi... 2 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 10 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 13 1
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 1
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 3
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 1
5-hydroxytryptamine receptor 1A ligand 2-[4-(quinolin-2-ylmeth... 2 91
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 8
Metabotropic glutamate receptor 2 and Metabotropic glutamate r... 5 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 5 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 9 3
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 0
Dipeptidyl peptidase 4 inhibitor SureCN3389584 family 2 2
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Progesterone receptor and Mineralocorticoid receptor ligand AG... 6 1
Prostaglandin E synthase inhibitor AGN-PC-09QHBK family 3 1
Prostaglandin E synthase and Aldo-keto reductase family 1 memb... 3 12
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 1 1
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075BGV ... 1 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 2
Renin and Potassium voltage-gated channel subfamily H member 2... 9 2
C-X-C chemokine receptor type 3 ligand (6aR,9R)-9-(pyrrolidine... 2 0
C-X-C chemokine receptor type 3 ligand (6aR,9R)-N-phenyl-4-(2-... 5 0
Smoothened homolog inhibitor (8aS)-N-[2-(3-cyanophenyl)pyridin... 3 4
CGMP-dependent protein kinase inhibitor AGN-PC-075XII family 25 7
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 1 4
Neuronal acetylcholine receptor subunit alpha-7 ligand 1-(4-me... 1 0
Melanin-concentrating hormone receptor 2 ligand N,N-dimethyl-3... 2 2
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
Macrophage colony-stimulating factor 1 receptor and Vascular e... 2 3
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 5 3
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Melanin-concentrating hormone receptor 1 and 5-hydroxytryptami... 2 0
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-4-m... 1 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Di... 2 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Translocator protein inhibitor CHEMBL2331870 family 2 0
Glucocorticoid receptor ligand 3,3,3-trifluoro-N-[(3S)-3-[1-(4... 10 4
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 7 0
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 2 0
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 2 1
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 2 2
Transient receptor potential cation channel subfamily V member... 1 0
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 2 18
C-C chemokine receptor type 3 and Cytochrome P450 2D6 ligand 1... 5 0
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 1 0
Bombesin receptor subtype-3 ligand SureCN13887096 family 3 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 2
Platelet-activating factor receptor ligand SureCN9853140 family 3 3
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 4
Transient receptor potential cation channel subfamily V member... 3 2
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(2-ph... 4 0
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(4-py... 9 0
CGMP-dependent protein kinase inhibitor AGN-PC-078XQ0 family 1 1
Melanin-concentrating hormone receptor 1 ligand SureCN4917950 ... 3 5
Thymidylate synthase inhibitor AGN-PC-00EUGY family 2 7
Melanin-concentrating hormone receptor 1 and Potassium voltage... 1 0
Neuropeptide Y receptor type 5 ligand AGN-PC-07CNLC family 1 1
Sterol O-acyltransferase 1 inhibitor SureCN7073167 family 4 2
Histamine H3 receptor ligand AGN-PC-09M6FC family 1 9
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 12 6
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 1 2
Androgen receptor ligand 4-(1-benzyl-2-oxoimidazo[4,5-b]pyridi... 1 1
Rho-associated protein kinase 2 and Rho-associated protein kin... 1 0
Transient receptor potential cation channel subfamily V member... 2 0
N-formyl peptide receptor 2 ligand 1-(1-methyl-3-oxo-5-propan-... 3 1
Acetylcholinesterase inhibitor CHEMBL267591 family 5 0
Reverse transcriptase/RNaseH inhibitor (4s)-6-chloro-4-cyclopr... 5 3
Acyl-CoA:cholesterol acyltransferase inhibitor AGN-PC-00GCQW f... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00127570 CHEMBL231206 Bioactive Isoquinoline Analogue, 38
CFAMM00127517 CHEMBL231104 Bioactive Isoquinoline Analogue, 34
CFAMM00127483 CHEMBL250370 Bioactive 1-[2-(4-fluorophenyl)-3-phenylpropyl]-3-isoquinolin-5-ylurea
CFAMM00127510 CHEMBL387996 Bioactive Isoquinoline Analogue, 32
CFAMM00127531 CHEMBL427266 Bioactive Isoquinoline Analogue, 39
CFAMM00127468 CHEMBL231518 Bioactive Isoquinoline Analogue, 45
CFAMM00127545 CHEMBL230896 Bioactive Isoquinoline Analogue, 30
CFAMM00127461 CHEMBL249946 Bioactive 1-(1-benzyl-1,2,3,4-tetrahydronaphthalen-2-yl)-3-isoquinolin-5-ylurea
CFAMM00127620 CHEMBL230998 Bioactive Isoquinoline Analogue, 33
CFAMM00127460 CHEMBL231517 Bioactive Isoquinoline Analogue, 43
CFAMM00127625 CHEMBL230997 Bioactive Isoquinoline Analogue, 31
CFAMM00127565 DCL000025 Clinical Trial Drug A-425619
CFAMM00127505 DNC007522 Investigative Drug 1-benzhydryl-3-(isoquinolin-5-yl)urea
CFAMM00127453 DNC007545 Investigative Drug 1-(isoquinolin-5-yl)-3-(4-morpholinobenzyl)urea
CFAMM00127506 DNC007521 Investigative Drug 1-(isoquinolin-5-yl)-3-(1-phenylpropyl)urea

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21767 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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