CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD163
Family Name Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family
No. of Seeds 28 No. of Other Members 263
Family Centroid CFAMM00140314 Functional Category Clinical Trial Drug with Human Metabolite & Natural Product
Superfamily Growth hormone secretagogue receptor type 1 Ligand TZP-101 Superfamily
Class Class 412

Cousin Family NamesSeedsMembers
Vasopressin V2 receptor ligand peptide analog Desmopressin family 111 1472
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Trypsin inhibitor polypeptide Aprotinin Family 7 68
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Oxytocin receptor Ligand Oxytocin Family 30 182
Beta adrenergic receptor Ligand Levobunolol Family 6 133
Beta-1 adrenergic receptor Ligand Esmolol Family 5 39
Beta-1 adrenergic receptor Ligand Metoprolol Family 29 90
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
Glucan synthesis regulatory protein Inhibitor Anidulafungin Fa... 2 5
Glucan synthesis regulatory protein Inhibitor Caspofungin Family 17 71
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Beta adrenergic receptor Ligand Dipivefrin Family 3 55
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
HIV-1 protease Inhibitor Lopinavir Family 4 25
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Growth hormone-releasing hormone receptor ligand polypeptide ... 14 34
Muscarinic acetylcholine receptor Ligand Methantheline Family 6 8
Mu-type opioid receptor Ligand Alvimopan Family 32 325
Renin Inhibitor Aliskiren Family 28 107
Zucapsacin family 7 177
Thymopentin family 20 133
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Endothelin-1 receptor Ligand Atrasentan Family 127 336
C-C chemokine receptor type 5 Ligand GW873140 Family 6 78
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
Substance-P receptor Ligand DA-5018 Family 14 73
Substance-P receptor Ligand Ezlopitant Family 10 207
Plitidepsin family 15 5
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
Flovagatran family 12 546
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Neuropeptide Y receptor type 1 Ligand Bibp 3226 Family 43 80
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
Plasmepsin-2 Inhibitor KNI-727 Family 3 37
5-hydroxytryptamine receptor 1A Ligand Robalzotan Family 9 41
Vasopeptidase Inhibitor Sampatrilat Family 25 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 20 35
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Histamine H3 receptor Ligand A-317920 Family 9 240
Cathepsin F and Cruzipain Inhibitor Benzoyl-arginine-alanine-m... 49 348
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Cruzipain Inhibitor WRR-204 Family 18 35
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Integrin beta-3 Inhibitor FK-633 Family 2 12
Proto-oncogene tyrosine-protein kinase Src Inhibitor Glu-pro-g... 8 4
Voltage-dependent N-type calcium channel subunit alpha-1B Liga... 2 2
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Integrin beta-3 Inhibitor RWJ-53419 Family 6 65
Proto-oncogene tyrosine-protein kinase Src Inhibitor Y-c[d-pen... 20 66
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-tyr(me)-agly-i... 2 1
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Neuromedin-K receptor Ligand PD-160946 Family 10 32
Cathepsin B and Cathepsin L1 Inhibitor MDL-2170 Family 17 24
Histamine H3 receptor Ligand A-349821 Family 49 228
Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-... 5 24
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Caspase-1 Inhibitor Z-vad-cho Family 8 34
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 2 10
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 36 12
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 46
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 23 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 31 5
Tubulin beta chain Inhibitor 6-ile-ustiloxin Family 4 3
Mu-type opioid receptor and Nociceptin receptor Ligand Ac-ryyr... 60 11
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Acetylcholinesterase and Cholinesterase Inhibitor Caproctamine... 7 17
Oxytocin receptor Ligand [mpa1, D-tyr(et)2, D-tic7]ot Family 43 26
C-X-C chemokine receptor type 4 Ligand Cyclo(-d-tyr-l-ala-l-ar... 25 23
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Prothrombin Inhibitor Cyclotheonamide E5 Family 3 0
Matrix metalloproteinase-9 and Collagenase 3 Inhibitor 4-amino... 1 8
Caspase-4 and Cathepsin D Inhibitor Grassystatin A Family 24 6
Fatty-acid amide hydrolase 1 Inhibitor 3-(trifluoromethyl)phen... 3 0
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 10 15
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Mu-type opioid receptor Ligand H-tyr-d-ala-aic-asp-val-val-gly... 48 8
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 8
Genome polyprotein Inhibitor Acasp-glu-cha-val-prb-cys Family 13 18
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Sodium-dependent dopamine transporter Inhibitor Bip-tyr-thr-pr... 8 2
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 48 10
Amine oxidase [flavin-containing] B Inhibitor (r)-n2-{4-[(3-ch... 3 0
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Gamma-secretase subunit APH-1B and Presenilin-1 Inhibitor 3114... 8 9
Vasopressin V1a receptor Ligand Vasopressin Analogue Family 4 3
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 5 2
Pol polyprotein inhibitor tert-butyl N-[(2S,3S,5R)-5-benzyl-3-... 2 3
Pol polyprotein inhibitor 180968-31-4 family 8 13
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
Prothrombin and Tissue-type plasminogen activator inhibitor CH... 10 5
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Neutrophil elastase inhibitor phenyl N-[(2S)-1-[(2S)-2-[[(3S)-... 10 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
Matrilysin and 72 kDa type IV collagenase inhibitor (3S,6R,7S)... 2 2
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Histamine H3 receptor ligand SureCN4319687 family 8 15
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0
Neutrophil elastase inhibitor (2S)-N-[(3S)-6-benzamido-5,5-dif... 6 10
Pol polyprotein inhibitor benzyl N-[(2S)-1-[[(2S,3S,4R,5S)-3,4... 21 5
Endothelin-1 receptor and Endothelin B receptor ligand (2R,3R,... 5 4
Endothelin-1 receptor and Endothelin B receptor ligand (2R,3R,... 3 2
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 3 4
Growth hormone secretagogue receptor type 1 ligand 2-amino-2-m... 1 0
Cathepsin K inhibitor [1-(3-methoxyphenyl)-2-methylpropan-2-yl... 2 10
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 3 7
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 1 13
Histamine H3 receptor ligand 1-(4-pentan-3-ylpiperazin-1-yl)-2... 1 1
Glutamate receptor ionotropic, kainate 2 ligand (2S,3S,4S)-4-[... 4 10
E3 ubiquitin-protein ligase XIAP inhibitor N-METHYLALANYL-3-ME... 3 14
Serine palmitoyltransferase 1 and Serine palmitoyltransferase ... 2 1
Renin inhibitor N-[(2S,4S,5S,7S)-7-[2-(1-acetylpiperidin-4-yl)... 2 1
Renin inhibitor (1R,5S)-N-cyclopropyl-N-[(3-methoxy-2-methylph... 4 4
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 6 1
Cathepsin B and Calpain-2 catalytic subunit inhibitor AGN-PC-0... 2 2
3-hydroxyacyl-CoA dehydrogenase type-2 and Retinal dehydrogena... 1 15
Substance-P receptor ligand AGN-PC-075NP5 family 4 8
Disintegrin and metalloproteinase domain-containing protein 17... 2 0
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 10
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 4 2
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6367561 f... 20 12
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 13
Neprilysin inhibitor SureCN389939 family 5 6
Pol polyprotein inhibitor AC1NQUJL family 10 11
Tyrosine--tRNA ligase, cytoplasmic inhibitor (2S)-2-[[(2S)-2-a... 5 2
Pol polyprotein inhibitor CHEMBL305466 family 4 7
Dipeptidyl peptidase 4 and Seprase inhibitor (2R)-2-[4-[[[(2S)... 17 19
Prostaglandin D2 receptor 2 ligand SureCN1713638 family 2 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-ethy... 7 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(4S)-3... 3 24
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6453971 f... 3 4
Growth hormone secretagogue receptor type 1 ligand tert-butyl ... 5 4
Pol polyprotein inhibitor AC1LADQG family 7 1
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6S... 1 0
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
Renin inhibitor [(1S,3R,4S)-3-amino-4-hydroxycyclopentyl]-[(3R... 2 3
Integrin beta-1 and Integrin alpha-4 inhibitor (4S)-4-[benzene... 7 0
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 3
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 6 3
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 4 6
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 12
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 4
Pol polyprotein inhibitor MDL 74538 family 11 1
Kappa-type opioid receptor and Cytochrome P450 2D6 ligand Sure... 4 0
Kappa-type opioid receptor and Cytochrome P450 2D6 ligand Sure... 4 3
NS3 inhibitor Proline-Based Macrocycle 24 family 6 6
NS3 inhibitor CHEMBL201121 family 1 4
Beta-1 adrenergic receptor ligand N-[2-[[(2S)-3-(2-cyanophenox... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 1 0
Histamine H3 receptor and Cytochrome P450 2D6 ligand ethyl 4-[... 5 5
Dipeptidyl peptidase 4 inhibitor 2-cyanopyrrolidine 21e family 6 7
Angiotensin-converting enzyme and Neprilysin inhibitor (2S,5R)... 15 3
Beta-secretase 1 and Cathepsin D inhibitor N-[(2S,3R)-1-(3,5-d... 10 15
Mu-type opioid receptor ligand 4-[(2S)-3-[[(2S)-1-(4-hydroxyph... 2 6
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 3 191
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-[cyano-(2-meth... 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Corticoster... 6 22
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 7 1
Beta-secretase 1 and Cathepsin B inhibitor N-[(2S)-1-[[(2S,3R)... 2 1
Motilin receptor ligand SureCN74051 family 1 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 2 0
Vasopressin V1a receptor and Vasopressin V1b receptor ligand C... 6 0
Integrin beta-3 and Integrin alpha-IIb inhibitor (2S)-5-(diami... 2 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand (5Z,8... 4 2
Beta-secretase 1 and Cathepsin D inhibitor N-[(2S,3R)-4-[[(4S)... 4 0
C-C chemokine receptor type 5 ligand 4-[4-[[4-[(5R)-3-cyclohex... 4 2
Angiotensin-converting enzyme 2 and Neprilysin inhibitor (2S)-... 6 1
Renin inhibitor (3S,6R)-6-(cyclohexylmethyl)-7-hydroxy-7-[[(2S... 1 0
Scytalone dehydratase inhibitor (1R)-2,2-dichloro-1-ethyl-N-[(... 9 1
Pol polyprotein inhibitor SDZ PRI 053 family 8 1
Calpain-1 catalytic subunit inhibitor 2-ethyl-1,1-dioxo-N-[(2S... 4 30
Beta-secretase 1 and Cathepsin E inhibitor 1-N-[(1R,2S)-3-(3,5... 3 8
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 3
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 2 0
C-C chemokine receptor type 1 ligand SureCN8184421 family 11 10
Integrin beta-1 and Integrin alpha-4 inhibitor (2R)-3-[4-(2-me... 18 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2-me... 4 0
Plasmepsin-2 and Cathepsin D inhibitor N-[2-(1,3-benzodioxol-5... 4 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 3 1
Scytalone dehydratase inhibitor (2R)-2-cyano-N-[(2R)-1-(2,3-di... 15 0
Pol polyprotein inhibitor N-[2-Hydroxy-2-(8-Isopropyl-6,9-Diox... 7 6
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6429531 f... 2 0
Disintegrin and metalloproteinase domain-containing protein 17... 2 0
72 kDa type IV collagenase and Collagenase 3 inhibitor SureCN7... 5 2
Follicle-stimulating hormone receptor ligand SureCN6140614 family 2 8
Histamine H3 receptor ligand SureCN7244264 family 1 0
Tryptase alpha/beta-1 and Tryptase delta inhibitor (2S,3R)-4-o... 4 5
Cathepsin S and Cathepsin L1 inhibitor benzyl N-[(2S)-1-oxo-1-... 2 2
Pol polyprotein inhibitor (3S)-N-tert-butyl-2-[(2R)-2-[(3S,6S,... 3 1
Pol polyprotein inhibitor AC1LALH8 family 2 1
Stromelysin-1 and Interstitial collagenase inhibitor (2R)-2-[4... 4 1
Neutrophil collagenase and Matrix metalloproteinase-9 inhibito... 1 0
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 0
Growth hormone secretagogue receptor type 1 ligand SureCN76477... 2 1
Cathepsin K and Cathepsin L1 inhibitor dipeptidyl nitrile, 16c... 1 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 11
Neprilysin inhibitor (2S)-4-methoxy-2-[[1-[[(1R,2S)-2-(4-metho... 1 0
NS3 and Non-structural protein 4A inhibitor (4S)-4-[[(2S)-3-ca... 1 0
Renin inhibitor ethyl N-[1-[[1-[[(2S,3R,4S)-1-cyclohexyl-3,4-d... 2 0
Scytalone dehydratase inhibitor 2-cyano-N-[(1S,2R)-1-(2-cyanop... 5 0
Beta-secretase 1 inhibitor 1-N-[(2S,3R)-1-(3,5-difluorophenyl)... 8 7
Histamine H3 receptor and D(3) dopamine receptor ligand AGN-PC... 1 0
Growth hormone secretagogue receptor type 1 ligand N-benzyl-2-... 5 19
Renin inhibitor (2S,4S,5S,7S)-5-amino-4-hydroxy-7-[[4-methoxy-... 2 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 2
Kappa-type opioid receptor ligand N-[(1S)-2-[(3S)-3-hydroxypyr... 2 0
Neuropeptide Y receptor type 1 and Sodium-dependent serotonin ... 2 7
Renin inhibitor methyl N-[[5-[[(2S,3S,5R)-2-amino-6-(butylamin... 1 0
Cathepsin K inhibitor (2S)-2-[[2-(3,4-dimethoxyphenyl)acetyl]a... 1 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 9
72 kDa type IV collagenase and Interstitial collagenase inhibi... 2 0
Caspase-1 inhibitor 3-[[(2S)-4-hydroxy-1-[(2S)-3-methyl-2-[[(E... 1 0
Angiotensin-converting enzyme inhibitor (2S,4S)-1-[(2S)-2-meth... 1 0
Melanocyte-stimulating hormone receptor and Melanocortin recep... 1 0
Signal transducer and activator of transcription 3 inhibitor [... 7 25
Kappa-type opioid receptor ligand 1-[4-acetyl-2-[[(3S)-3-hydro... 1 0
Stromelysin-1 inhibitor (2R)-2-[[(2S)-1-[(6S)-6-(methylcarbamo... 1 1
Caspase-1 inhibitor 3-[[(2S)-2-[[(2S)-3-methyl-2-(phenylmethox... 1 3
Arachidonate 5-lipoxygenase and Arachidonate 15-lipoxygenase i... 1 2
Genome polyprotein inhibitor (2S)-6-amino-N-[(2S)-6-amino-1-[[... 2 0
Signal transducer and activator of transcription 3 inhibitor [... 3 1
Renin inhibitor N-[2-[[(2R)-1-[[(2S,3R,4S)-3,4-dihydroxy-6-met... 1 0
Substance-P receptor ligand (2S)-N-[(2S)-1-[benzyl(methyl)amin... 2 2
Dipeptidyl peptidase 4 inhibitor 7-[(3R)-3-amino-4-(2,4,5-trif... 2 0
Beta-lactamase and Histone-lysine N-methyltransferase 2A inhib... 1 7
Metabotropic glutamate receptor 1 ligand methyl (2R)-2-[[(1aR,... 2 0
N-acylethanolamine-hydrolyzing acid amidase inhibitor (4-pheny... 1 0
Lysosomal alpha-glucosidase inhibitor MLS000587024 family 1 0
Pol polyprotein inhibitor AC1MHYEO family 1 0
Tyrosine-protein phosphatase non-receptor type 2 and Tyrosine-... 6 0
Sodium channel protein type 1 subunit alpha and Sodium channel... 2 0
(2S)-1-[2-[4-(8-methoxy-2-oxochromen-3-yl)phenoxy]acetyl]pyrro... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00140260 CHEMBL396413 Bioactive 2-[[(7S,10R,13R)-6,9,12-trioxo-10-propan-2-yl-13-[[3-(trifluoromethyl)phenyl]methyl]-17-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-trien-7-yl]methyl]guanidine
CFAMM00140090 CHEMBL41328 Bioactive 2-cyano-2-cyclopropyl-N-[(1S,2R)-1-(2,5-difluorophenoxy)-1-phenylpropan-2-yl]acetamide
CFAMM00140175 CHEMBL274876 Bioactive SureCN10150187
CFAMM00140203 CHEMBL1923625 Bioactive (7R,10R,13S)-13-cyclopropyl-7-[(4-fluorophenyl)methyl]-10,11-dimethyl-17-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-6,9,12-trione
CFAMM00140343 CHEMBL1923609 Bioactive (7R,10R,13S)-7-benzyl-13-[(2S)-butan-2-yl]-10,11-dimethyl-17-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-6,9,12-trione
CFAMM00140181 CHEMBL233711 Bioactive SureCN13392456
CFAMM00140158 CHEMBL384501 Bioactive SureCN73791
CFAMM00140202 CHEMBL1923626 Bioactive (7R,10R,13S)-13-cyclopropyl-10,11-dimethyl-7-[[4-(trifluoromethyl)phenyl]methyl]-17-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-6,9,12-trione
CFAMM00140102 CHEMBL1923617 Bioactive (7R,10R,13S)-13-[(2S)-butan-2-yl]-7-[(4-chlorophenyl)methyl]-10,11-dimethyl-17-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-6,9,12-trione
CFAMM00140311 CHEMBL1923640 Bioactive CHEMBL1923640
CFAMM00140172 CHEMBL1923627 Bioactive (7R,10R,13S)-13-cyclopropyl-10,11-dimethyl-7-[(4-methylphenyl)methyl]-17-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-6,9,12-trione
CFAMM00140194 CHEMBL296357 Bioactive 2-cyano-N-[(1S,2R)-1-(2-cyano-5-fluorophenoxy)-1-phenylpropan-2-yl]-3-methylbutanamide
CFAMM00140324 CHEMBL43632 Bioactive 2-cyano-N-[(1S,2R)-1-(2,5-difluorophenoxy)-1-phenylpropan-2-yl]butanamide
CFAMM00140392 CHEMBL1790231 Bioactive (2S)-2-acetamido-N-[(2S)-1-[[(2S,3R)-4-[[(3S,6S)-6-[(2R)-butan-2-yl]-4,7-dioxo-12-oxa-5,8-diazabicyclo[11.2.2]heptadeca-1(15),13,16-trien-3-yl]amino]-3-hydroxy-1-phenylbutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-4-methylpentanamide
CFAMM00140295 CHEMBL1923637 Bioactive (7R,10R,13S)-13-cyclopropyl-7-[(4-fluorophenyl)methyl]-10,11,15-trimethyl-17-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-6,9,12-trione
CFAMM00140223 CHEMBL2316217 Bioactive (3S,7R,8aR)-2-[(2S)-2-(4,4-difluorocyclohexyl)-2-[[(2S)-2-(methylamino)propanoyl]amino]acetyl]-N-[(4R)-3,4-dihydro-2H-chromen-4-yl]-7-ethoxy-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazine-3-carboxamide
CFAMM00140170 CHEMBL1923628 Bioactive (7R,10R,13S,16R)-13-cyclopropyl-7-[(4-fluoro-3-methylphenyl)methyl]-10,11,16-trimethyl-17-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-6,9,12-trione
CFAMM00140099 CHEMBL1923610 Bioactive (7R,10R,13S)-7-benzyl-13-cyclopropyl-10,11-dimethyl-17-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-6,9,12-trione
CFAMM00140130 CHEMBL385087 Bioactive SureCN73779
CFAMM00140308 CHEMBL1790229 Bioactive (2S)-N-[(2S,3R)-4-[[(3S,6S)-6-[(2R)-butan-2-yl]-4,7-dioxo-12-oxa-5,8-diazabicyclo[11.2.2]heptadeca-1(15),13,16-trien-3-yl]amino]-3-hydroxy-1-phenylbutan-2-yl]-3-methyl-2-(2-oxopyrrolidin-1-yl)butanamide
CFAMM00140237 CHEMBL393315 Bioactive SureCN13392209
CFAMM00140066 CHEMBL1794029 Bioactive (3S,6S)-3-[(1R)-3-amino-3-[(3R,6S)-6-[(2S)-butan-2-yl]-4,7-dioxo-12-oxa-5,8-diazabicyclo[11.2.2]heptadeca-1(15),13,16-trien-3-yl]-1-hydroxypropyl]-6-propan-2-yl-13-oxa-4,7-diazabicyclo[12.2.2]octadeca-1(16),14,17-triene-5,8-dione
CFAMM00140136 CHEMBL289381 Bioactive 2-cyano-N-[(1S,2R)-1-(2-cyano-5-fluorophenoxy)-1-phenylpropan-2-yl]butanamide
CFAMM00140169 CHEMBL1923629 Bioactive (7R,10R,13S,16R)-13-cyclohexyl-7-[(4-fluorophenyl)methyl]-10,11,16-trimethyl-17-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-6,9,12-trione
CFAMM00140390 CHEMBL1790234 Bioactive (3S,6S)-3-[(1R)-2-[[(3S,6S)-6-[(2R)-butan-2-yl]-4,7-dioxo-12-oxa-5,8-diazabicyclo[11.2.2]heptadeca-1(15),13,16-trien-3-yl]amino]-1-hydroxyethyl]-6-propan-2-yl-13-oxa-4,7-diazabicyclo[12.2.2]octadeca-1(16),14,17-triene-5,8-dione
CFAMM00140313 CHEMBL1923642 Bioactive (7R,10R,13S)-13-cyclopropyl-20-fluoro-7-[(4-fluorophenyl)methyl]-10,11-dimethyl-17-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(18),19,21-triene-6,9,12-trione
CFAMM00140204 CHEMBL1923623 Bioactive (7R,10R,13S)-13-cyclopropyl-7-[(2-fluorophenyl)methyl]-10,11-dimethyl-17-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-6,9,12-trione
CFAMM00140314 DCL000255 Clinical Trial Drug TZP-101

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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Computer-aided Drug Design
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Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543