CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD164
Family Name Phospholipase A2, membrane associated Inhibitor Varespladib Family
No. of Seeds 37 No. of Other Members 190
Family Centroid CFAMM00140612 Functional Category Clinical Trial Drug with Natural Product
Superfamily Phospholipase A2, membrane associated and Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J33) Binder Superfamily
Class Class 297

Cousin Family NamesSeedsMembers
Cyclooxygenase Inhibitor Indomethacin Family 6 271
Cyclooxygenase Inhibitor Oxaprozin Family 33 450
Arachidonate 5-lipoxygenase-activating protein Inhibitor DG031... 3 206
Arachidonate 5-lipoxygenase Inhibitor MK-591 Family 9 161
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 4 42
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Peroxisome proliferator-activated receptor gamma and Peroxisom... 15 94
Fatty-acid amide hydrolase 1 Inhibitor 1-(5-(pyridin-2-yl)oxaz... 10 142
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand WIN-5... 12 52
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-[5-(4-hydroxyphe... 4 36
Prostaglandin G/H synthase 2 Inhibitor L-761000 Family 8 44
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 7
Peroxisome proliferator-activated receptor delta ligand SureCN... 8 19
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 7 11
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 391
Phospholipase A2 inhibitor SureCN7046992 family 2 3
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 8 21
Phospholipase A2 inhibitor 2-[2-ethyl-1-oxamoyl-3-[(5-thiophen... 1 0
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 4 14
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Renin inhibitor AGN-PC-09M9MJ family 2 23
Cysteinyl leukotriene receptor 1 ligand AGN-PC-075KCE family 5 33
Retinoic acid receptor beta and Retinoic acid receptor alpha l... 2 2
Cellular tumor antigen p53 inhibitor CHEMBL1395699 family 1 30
Thromboxane-A synthase and Thromboxane A2 receptor ligand Sure... 5 37
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
Histamine H3 receptor ligand SureCN2784306 family 5 3
Fatty-acid amide hydrolase 1 inhibitor methyl 6-[2-[3-(4-pheny... 8 5
Peroxisome proliferator-activated receptor gamma ligand AGN-PC... 5 12
Phospholipase A2, membrane associated inhibitor AGN-PC-007MX4 ... 1 0
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [5-(o... 4 4
Prostaglandin D2 receptor and Prostaglandin E2 receptor EP2 su... 2 0
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Peroxisome proliferator-activated receptor delta and Peroxisom... 3 17
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Peroxisome proliferator-activated receptor alpha and Peroxisom... 1 4
Sphingosine 1-phosphate receptor 1 ligand 6-[2-[6-propan-2-ylo... 1 1
Sphingosine 1-phosphate receptor 1 ligand 6-[2-[4-phenyl-3-(tr... 2 3
Cytosolic phospholipase A2 inhibitor AGN-PC-00BH8R family 6 13
Peroxisome proliferator-activated receptor gamma and Peroxisom... 1 3
Potassium voltage-gated channel subfamily H member 2 and 5-hyd... 2 2
Peroxisome proliferator-activated receptor alpha and Peroxisom... 5 2
Peroxisome proliferator-activated receptor gamma and Peroxisom... 10 5
Peroxisome proliferator-activated receptor gamma and Peroxisom... 3 0
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 3
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 7 1
Coagulation factor X and Prothrombin inhibitor SureCN6434488 f... 3 13
Cannabinoid receptor 1 ligand (4-hydroxynaphthalen-1-yl)-[1-(2... 2 0
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 1 8
Peroxisome proliferator-activated receptor gamma and Peroxisom... 9 0
Ras guanyl-releasing protein 3 and Protein kinase C alpha type... 2 6
Peroxisome proliferator-activated receptor gamma ligand SureCN... 1 0
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 3
Arachidonate 5-lipoxygenase inhibitor AGN-PC-071TED family 9 12
Phospholipase A2, membrane associated inhibitor 2-(1-benzyl-2-... 2 1
Peroxisome proliferator-activated receptor gamma and Peroxisom... 1 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00140427 CHEMBL123774 Bioactive SureCN7009615
CFAMM00140579 CHEMBL148649 Bioactive 2-(1-benzyl-2-ethyl-3-oxamoylindol-4-yl)oxypropanoic acid
CFAMM00140622 CHEMBL477548 Bioactive SureCN13632229
CFAMM00140545 CHEMBL357979 Bioactive me-indoxam
CFAMM00140571 CHEMBL422667 Bioactive SureCN818067
CFAMM00140510 CHEMBL345488 Bioactive SureCN819398
CFAMM00140538 CHEMBL355944 Bioactive SureCN819886
CFAMM00140459 CHEMBL425869 Bioactive SureCN6334776
CFAMM00140425 CHEMBL347957 Bioactive SureCN818951
CFAMM00140458 CHEMBL436456 Bioactive 2-[1-[(2-benzylphenyl)methyl]-2-ethyl-3-oxamoylindol-4-yl]oxyacetic acid
CFAMM00140516 CHEMBL121627 Bioactive SureCN7006576
CFAMM00140530 CHEMBL332547 Bioactive SureCN7018369
CFAMM00140592 CHEMBL489651 Bioactive SureCN2901702
CFAMM00140424 CHEMBL425696 Bioactive SureCN5157692
CFAMM00140523 CHEMBL331755 Bioactive SureCN7013861
CFAMM00140599 CHEMBL490029 Bioactive SureCN671319
CFAMM00140576 CHEMBL332957 Bioactive methyl 2-[2-ethyl-1-oxamoyl-3-[(3-phenylphenyl)methyl]indolizin-8-yl]oxyacetate
CFAMM00140409 CHEMBL332993 Bioactive SureCN5892140
CFAMM00140555 CHEMBL121422 Bioactive 2-[2-ethyl-3-(naphthalen-2-ylmethyl)-1-oxamoylindolizin-8-yl]oxyacetic acid
CFAMM00140618 CHEMBL345986 Bioactive SureCN818585
CFAMM00140493 CHEMBL179658 Bioactive SureCN6331336
CFAMM00140568 CHEMBL179118 Bioactive SureCN6333071
CFAMM00140443 CHEMBL121645 Bioactive SureCN5892138
CFAMM00140470 CHEMBL515637 Bioactive SureCN5157654
CFAMM00140535 CHEMBL179966 Bioactive 2-[[1-[(3-fluorophenyl)methyl]-2-methyl-3-oxamoyl-7,8-dihydro-6H-cyclopenta[g]indol-4-yl]oxy]acetic acid
CFAMM00140408 CHEMBL514705 Bioactive AGN-PC-04UIBK
CFAMM00140422 CHEMBL121609 Bioactive SureCN7006865
CFAMM00140561 CHEMBL361552 Bioactive SureCN6333176
CFAMM00140528 CHEMBL356606 Bioactive SureCN818498
CFAMM00140632 CHEMBL359005 Bioactive (2R)-2-(1-benzyl-2-methyl-3-oxamoylindol-4-yl)oxypropanoic acid
CFAMM00140610 CHEMBL514692 Bioactive SureCN13888591
CFAMM00140498 CHEMBL433701 Bioactive SureCN5538147
CFAMM00140573 CHEMBL357804 Bioactive SureCN819436
CFAMM00140540 CHEMBL121617 Bioactive SureCN5892148
CFAMM00140596 CHEMBL148795 Bioactive 2-[1-[(2-chlorophenyl)methyl]-2-methyl-3-oxamoylindol-4-yl]oxyacetic acid
CFAMM00140546 CHEMBL414424 Bioactive SureCN7012880
CFAMM00140612 DCL000258 Clinical Trial Drug Varespladib

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21767 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543