CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD165
Family Name Tyrosine-protein kinase Lck and Aurora kinase B Inhibitor VX-680 Family
No. of Seeds 28 No. of Other Members 56
Family Centroid CFAMM00140735 Functional Category Clinical Trial Drug
Superfamily Tyrosine-protein kinase Lck and Aurora kinase B Inhibitor VX-680 Superfamily
Class Class 935

Cousin Family NamesSeedsMembers
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Type-1 angiotensin II receptor Ligand Forasartan Family 3 253
Transient receptor potential cation channel subfamily V member... 15 457
Hepatocyte growth factor receptor Ligand SGX523 Family 1 15
HER Inhibitor AC480 Family 4 67
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
C-reactive protein Inhibitor ISIS-CRP Family 4 105
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
PF-4217903 family 14 65
PF-3758309 family 1 8
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
TGF-beta receptor type-1 Ligand 4-(3-pyridin-2-yl-1h-pyrazol-4... 3 63
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Glycogen synthase kinase-3 beta Inhibitor N-(6-(pyridin-4-yl)-... 4 23
Cyclin-dependent kinase 2 and Mitogen-activated protein kinase... 7 30
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... 22 18
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Xanthine dehydrogenase/oxidase Inhibitor 3,5-di(pyridin-4-yl)-... 6 3
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family 4 8
Mitogen-activated protein kinase 14 inhibitor 6-[3-amino-5-(2-... 4 9
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 13 100
5-hydroxytryptamine receptor 6 ligand AGN-PC-0BIUF2 family 25 11
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
Ephrin type-B receptor 4 ligand SureCN3289519 family 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 13 10
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 6 1
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
Adenosine receptor A3 and Adenosine receptor A2a ligand SureCN... 8 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 2
DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... 2 10
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 3
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Serine/threonine-protein kinase B-raf inhibitor SureCN3495787 ... 8 1
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-(4-a... 8 11
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 8
Prothrombin and Survival motor neuron protein inhibitor CHEMBL... 2 14
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Survival motor neuron protein inhibitor CHEMBL1583999 family 1 3
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QJGR family 3 13
Insulin-like growth factor 1 receptor ligand AGN-PC-09QGLU family 3 1
5-hydroxytryptamine receptor 6 ligand 3-(benzenesulfonyl)-N,5-... 4 1
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07CBUP family 2 3
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 2 18
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 9 3
Glucose-dependent insulinotropic receptor ligand 4-({Ethyl-[1-... 6 12
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 4
Aurora kinase A inhibitor AGN-PC-0A9UUA family 4 1
Tyrosine-protein kinase JAK2 inhibitor N-tert-butyl-3-[2-[3-fl... 4 14
Aurora kinase B and Aurora kinase A inhibitor 2-[(3S,4S)-3-hyd... 22 5
Aurora kinase B and Aurora kinase A inhibitor 2-[(3S,4S)-3-(2-... 4 0
Metabotropic glutamate receptor 4 and Potassium voltage-gated ... 2 15
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL1... 7 4
TGF-beta receptor type-1 ligand 3-(6-methylpyridin-2-yl)-N-phe... 21 0
Casein kinase II subunit alpha inhibitor AGN-PC-0766PM family 4 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Protein-tyrosine kinase 6 and KH domain-containing, RNA-bindin... 21 6
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 4 ... 2 1
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 11 3
Mitogen-activated protein kinase 14 inhibitor 1-(5-tert-butyl-... 2 0
Vascular endothelial growth factor receptor 1 and Vascular end... 4 0
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 1
Casein kinase II subunit alpha and Homeodomain-interacting pro... 5 0
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-(cyc... 3 0
Casein kinase II subunit alpha inhibitor 7-(cyclopropylamino)-... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Mitogen-activated protein kinase 14 inhibitor imidazole 81 family 2 1
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-09QXA7 fa... 16 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 3 0
Protein kinase C theta type and Protein kinase C delta type in... 9 0
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
Aurora kinase B and Aurora kinase A inhibitor 6-chloro-2-methy... 2 4
Mast/stem cell growth factor receptor Kit and Proto-oncogene t... 3 5
Proto-oncogene tyrosine-protein kinase Src and Mast/stem cell ... 4 1
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-[(1-... 9 0
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-0CSEAG family 2 1
Tyrosine-protein kinase JAK2 inhibitor N-(3-methylphenyl)-5-(3... 2 4
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 3 6
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Epidermal growth factor receptor and Vascular endothelial grow... 3 1
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 6 6
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 4 7
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 5 4
Adenosine receptor A3 ligand SureCN6716937 family 1 0
High affinity nerve growth factor receptor ligand SureCN490352... 3 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 11 1
Aurora kinase A and Glycogen synthase kinase-3 beta inhibitor ... 7 0
Aurora kinase A and Glycogen synthase kinase-3 beta inhibitor ... 2 0
Aurora kinase A inhibitor SureCN2205392 family 2 2
Insulin-like growth factor 1 receptor and G1/S-specific cyclin... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00140693 CHEMBL563682 Bioactive SureCN13004577
CFAMM00140709 CHEMBL1822485 Bioactive N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]cyclopropanecarboxamide
CFAMM00140724 CHEMBL1822490 Bioactive N-[4-[6-[[2-(4-methylpiperazin-1-yl)-2-oxoacetyl]amino]-4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]cyclopropanecarboxamide
CFAMM00140658 CHEMBL549668 Bioactive AGN-PC-07C5V4
CFAMM00140745 CHEMBL484006 Bioactive SureCN12102820
CFAMM00140691 CHEMBL564941 Bioactive SureCN2203359
CFAMM00140708 CHEMBL1822486 Bioactive N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]-6-(3-piperidin-1-ylpropanoylamino)pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]cyclopropanecarboxamide
CFAMM00140723 CHEMBL484950 Bioactive SureCN2204454
CFAMM00140657 CHEMBL561421 Bioactive SureCN2205912
CFAMM00140700 CHEMBL557279 Bioactive SureCN2205038
CFAMM00140690 CHEMBL557682 Bioactive N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]-6-pyridin-3-ylpyrimidin-2-yl]sulfanylphenyl]propanamide
CFAMM00140707 CHEMBL1822487 Bioactive N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]-6-[(2-morpholin-4-ylacetyl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]cyclopropanecarboxamide
CFAMM00140722 CHEMBL484951 Bioactive SureCN12338787
CFAMM00140699 CHEMBL560556 Bioactive AGN-PC-02VRGG
CFAMM00140674 CHEMBL485186 Bioactive SureCN12338743
CFAMM00140728 CHEMBL1822494 Bioactive 2-(dimethylamino)-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide
CFAMM00140752 CHEMBL565183 Bioactive AGN-PC-044ZTR
CFAMM00140653 CHEMBL561617 Bioactive AGN-PC-07C4WB
CFAMM00140661 CHEMBL2163389 Bioactive N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]-2-[(3R)-3-(piperidine-1-carbonyl)pyrrolidin-1-yl]acetamide
CFAMM00140672 CHEMBL482778 Bioactive SureCN12338772
CFAMM00140651 CHEMBL484609 Bioactive SureCN1080455
CFAMM00140671 CHEMBL482779 Bioactive SureCN12338729
CFAMM00140703 CHEMBL560630 Bioactive N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]-6-pyridin-4-ylpyrimidin-2-yl]sulfanylphenyl]propanamide
CFAMM00140732 CHEMBL564449 Bioactive SureCN2204610
CFAMM00140725 CHEMBL1822491 Bioactive 2-(cyclopropylamino)-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide
CFAMM00140659 CHEMBL485351 Bioactive SureCN12338735
CFAMM00140685 CHEMBL554941 Bioactive SureCN2204846
CFAMM00140735 DCL000259 Clinical Trial Drug VX-680

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21785 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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