CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Transient receptor potential cation channel subfamily V member 1 Ligand ABT-102 Family
No. of Seeds 12 No. of Other Members 108
Family Centroid CFAMM00127700 Functional Category Clinical Trial Drug
Superfamily Transient receptor potential cation channel subfamily V member 1 Ligand ABT-102 Superfamily
Class Class 826

Cousin Family NamesSeedsMembers
Macrophage colony-stimulating factor 1 Inhibitor ABT-869 Family 8 56
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
NKP-1339 family 3 7
Glycogen synthase kinase-3 beta Inhibitor N-(6-(pyridin-4-yl)-... 4 23
Acetylcholinesterase Inhibitor 3-[2-(1-benzyl-piperidin-4-yl)-... 2 9
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 6
Calcitonin gene-related peptide type 1 receptor and Cytochrome... 19 12
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand N-(1h... 2 12
Cytochrome P450 3A4 Inhibitor 5-(2-phenethylpiperazin-1-yl)-1h... 12 35
Histamine H3 receptor and Potassium voltage-gated channel subf... 4 33
Ephrin type-B receptor 4 ligand SureCN3289519 family 4 2
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 10 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 5 11
Cell division cycle 7-related protein kinase and Protein DBF4 ... 1 2
cAMP-dependent protein kinase catalytic subunit PRKX and Ribos... 1 2
cAMP-dependent protein kinase catalytic subunit PRKX and Ribos... 1 1
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 5 3
C-C chemokine receptor type 3 ligand 1-(3-chloro-2H-indazol-5-... 1 1
Rho-associated protein kinase 2 and Rho-associated protein kin... 2 1
Rho-associated protein kinase 2 inhibitor 1-(3-hydroxy-1-pheny... 3 3
Glucocorticoid receptor ligand 3,3,3-trifluoro-N-[(3S)-3-[1-(4... 10 4
Pol polyprotein inhibitor AC1LAMOI family 12 0
C-C chemokine receptor type 3 and Cytochrome P450 2D6 ligand 1... 5 0
Cell division cycle 7-related protein kinase and Dual specific... 3 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 1 0
P2X purinoceptor 7 inhibitor N-cyano-N'-(2-methylphenyl)-4-[2-... 2 1
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN9057529 f... 2 0


External ID

Functional Category

Molecule Name

CFAMM00127677 CHEMBL254867 Bioactive SureCN1854692
CFAMM00127740 CHEMBL398834 Bioactive SureCN1859391
CFAMM00127676 CHEMBL254866 Bioactive SureCN1860664
CFAMM00127642 CHEMBL255046 Bioactive SureCN1860077
CFAMM00127719 CHEMBL251922 Bioactive SureCN5479641
CFAMM00127641 CHEMBL255045 Bioactive SureCN5475062
CFAMM00127653 CHEMBL1684262 Bioactive 1-(8-tert-butyl-1-methyl-3,4-dihydro-2H-quinolin-4-yl)-3-(1H-indazol-4-yl)urea
CFAMM00127666 CHEMBL401129 Bioactive SureCN1860594
CFAMM00127700 DCL000027 Clinical Trial Drug ABT-102
CFAMM00127758 DNC008975 Investigative Drug A-795614
CFAMM00127669 DNC007523 Investigative Drug (R)-1-(1H-indazol-4-yl)-3-(1-p-tolylethyl)urea
CFAMM00127667 DNC007524 Investigative Drug (S)-1-(1H-indazol-4-yl)-3-(1-p-tolylethyl)urea

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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