CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD177
Family Name Dihydroorotate dehydrogenase Inhibitor Brequinar Family
No. of Seeds 9 No. of Other Members 122
Family Centroid CFAMM00141215 Functional Category Clinical Trial Drug with Human Metabolite & Natural Product
Superfamily Dihydroorotate dehydrogenase Inhibitor Brequinar Superfamily
Class Class 943

Cousin Family NamesSeedsMembers
3-hydroxy-3-methylglutaryl-coenzyme A reductase Inhibitor Fluv... 6 53
Histamine H1 receptor Ligand (s)-(+)-dimethindene Maleate Family 6 12
Arachidonate 5-lipoxygenase-activating protein Inhibitor DG031... 3 206
Neuromedin-K receptor Ligand Talnetant Family 3 49
Retinoic acid receptor alpha Ligand LG100268 Family 2 33
Dipeptidyl peptidase 4 Inhibitor TAK-100 Family 5 7
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 4 42
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
Dihydroorotate dehydrogenase Inhibitor Cinchoninic Acid Family 1 21
Fatty acid-binding protein, adipocyte Inhibitor 2-(3-methyl-in... 5 9
Tyrosine-protein phosphatase non-receptor type 1 Ligand Cauler... 2 8
Lethal factor Inhibitor 3-(2,5-dimethyl-1h-pyrrol-1-yl)benzoic... 2 44
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
Fatty acid-binding protein, adipocyte Inhibitor 1-benzyl-2,3-d... 1 8
Egl nine homolog 2 Inhibitor Pyridine-2,4-dicarboxylic Acid Fa... 2 21
Prostaglandin D2 receptor 2 Ligand 2-(2-benzhydryl-4-phenylthi... 14 61
Kinesin-like protein KIF11 Inhibitor Methyl 7-tert-butyl-9h-ca... 2 9
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand Isoqui... 1 6
Metabotropic glutamate receptor 5 Ligand (3-(2-methylquinolin-... 3 6
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Neuromedin-K receptor and Substance-K receptor ligand 2-[2-phe... 2 2
Prostaglandin E2 receptor EP4 subtype and Prostaglandin D2 rec... 8 17
Adenosine receptor A3 and Adenosine receptor A1 ligand propyl ... 6 63
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 2 4
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 10 4
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 18
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 3 28
Leukotriene B4 receptor 1 ligand SureCN8772238 family 1 1
Cysteinyl leukotriene receptor 2 and Cysteinyl leukotriene rec... 1 7
Type-1 angiotensin II receptor ligand 5-butyl-2-(2-phenylethyl... 11 27
NS5B protein inhibitor AC1NQMYG family 6 12
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [(4R,... 3 7
Cysteinyl leukotriene receptor 1 ligand (2S)-3-[(1S)-3-(2-acet... 6 1
Insulin-like growth factor-binding protein 4 and Insulin-like ... 4 44
Retinoic acid receptor alpha and Retinoic acid receptor beta l... 1 2
Cannabinoid receptor 2 ligand [(4R,4aS,8aR)-4-hydroxy-4-phenyl... 2 41
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 4
Dipeptidyl peptidase 4 inhibitor AGN-PC-09QM95 family 1 1
Acetylcholinesterase inhibitor CHEMBL1651140 family 4 4
Dipeptidyl peptidase 4 inhibitor AGN-PC-09QKOM family 5 8
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor AG... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [(4S,... 5 2
NS5B protein inhibitor AGN-PC-00A17Z family 1 23
Cysteinyl leukotriene receptor 1 and Peripheral myelin protein... 1 1
NS5B protein inhibitor AC1O5AET family 3 1
NS5B protein inhibitor AC1NQMYP family 5 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 1
Prostaglandin D2 receptor 2 ligand 2-[1-(4-benzamidobenzoyl)is... 4 9
Arachidonate 5-lipoxygenase-activating protein inhibitor methy... 12 3
Egl nine homolog 1 inhibitor 2-[5-methyl-6-[[1-oxo-2-(4-phenyl... 4 3
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 10 2
Prostaglandin E synthase inhibitor 3-[4-(3-cyanopropoxy)-3-met... 2 4
Plasmepsin-2 and Cathepsin D inhibitor N'-(3,4-dimethylacridin... 1 3
Gonadotropin-releasing hormone receptor ligand SureCN7905635 f... 2 2
Insulin-like growth factor-binding protein 3 inhibitor (1E)-1-... 2 0
Proline--tRNA ligase, cytoplasmic and Bifunctional glutamate/p... 1 6
Gonadotropin-releasing hormone receptor ligand 4-[2-[[(2S)-2-[... 1 0
Tyrosine-protein phosphatase non-receptor type 1 and Receptor-... 1 0
Beta-3 adrenergic receptor ligand SureCN5704018 family 4 1
Capsid scaffolding protein inhibitor 4-[[[5-[(E)-2-(7-chloroqu... 1 1
Peroxisome proliferator-activated receptor gamma ligand AGN-PC... 4 4
Cysteinyl leukotriene receptor 1 ligand 6-bromo-4-oxo-3-(quino... 3 1
Glutamate carboxypeptidase 2 inhibitor 1-[(3-carboxyphenyl)met... 4 11
Integrase inhibitor AC1LARQ6 family 1 2
NS5B protein inhibitor SureCN2997714 family 2 2
Fatty acid-binding protein, adipocyte and Fatty acid-binding p... 1 0
Thrombopoietin receptor ligand AGN-PC-077M9L family 2 4
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 3
Integrase and Serine/threonine-protein kinase pim-1 inhibitor ... 3 0
Serine/threonine-protein kinase pim-1 and Dual specificity tyr... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00141354 CHEMBL555910 Bioactive 4-[[5-[[3-[(E)-2-(6,7-difluoroquinolin-2-yl)ethenyl]phenyl]methyl]-3,4-dihydro-1H-pyrido[4,3-b]indol-2-yl]methyl]benzoic acid
CFAMM00141245 CHEMBL38692 Bioactive 3-methyl-2-(4-phenylphenyl)-6-(trifluoromethyl)quinoline-4-carboxylic acid
CFAMM00141337 CHEMBL290910 Bioactive AGN-PC-00OI2B
CFAMM00141327 CHEMBL41719 Bioactive 4-Quinolinecarboxylic acid, 2-[1,1'-biphenyl]-4-yl-6-fluoro-3-hydroxy-
CFAMM00141285 CHEMBL39448 Bioactive AGN-PC-073LZY
CFAMM00141306 CHEMBL39162 Bioactive AGN-PC-00OI27
CFAMM00141215 DCL000272 Clinical Trial Drug Brequinar sodium
CFAMM00141250 DNC006030 Investigative Drug BREQUINAR
CFAMM00141301 DNC002634 Investigative Drug Brequinar Analog

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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