CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD186
Family Name Prostaglandin G/H synthase 2 Inhibitor Rpr 200765a Family
No. of Seeds 9 No. of Other Members 125
Family Centroid CFAMM00141624 Functional Category Clinical Trial Drug
Superfamily Prostaglandin G/H synthase 2 Inhibitor Rpr 200765a Superfamily
Class Class 920

Cousin Family NamesSeedsMembers
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
GDC-0349 family 44 77
JAK Inhibitor Momelotinib Family 33 83
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family 3 33
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Adenosine receptor A3 and Dual specificity mitogen-activated p... 5 27
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Serine/threonine-protein kinase mTOR Inhibitor 4-(2-(1h-indol-... 2 15
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
Epidermal growth factor receptor ligand N-[4-(3-chloro-4-fluor... 8 4
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Casein kinase I isoform delta and Casein kinase I isoform gamm... 1 2
Serine/threonine-protein kinase mTOR inhibitor 5-(2-amino-3H-b... 3 1
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152412 family 8 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 0
Protein kinase C theta type and Protein kinase C delta type in... 9 0
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 16 0
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Sterol O-acyltransferase 1 inhibitor SureCN9738287 family 1 15
Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family 2 0
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
Serine/threonine-protein kinase B-raf inhibitor imidazole-base... 2 0
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 1 0
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 1 12
Sterol O-acyltransferase 1 inhibitor 2-[4-[4-[2-(4,5-diphenyl-... 1 0
Sterol O-acyltransferase 1 inhibitor 1-[4-[2-(4,5-diphenyl-1H-... 2 0
5H-pyrimido[5,4-b]indol-4-amine NP N-((1,3-dioxolan-2-yl)methy... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00141630 CHEMBL308203 Bioactive SureCN5767427
CFAMM00141584 CHEMBL70053 Bioactive SureCN5770144
CFAMM00141643 CHEMBL69319 Bioactive SureCN6075386
CFAMM00141610 CHEMBL347592 Bioactive AGN-PC-03MVXU
CFAMM00141603 CHEMBL309802 Bioactive SureCN5770749
CFAMM00141654 CHEMBL161197 Bioactive SureCN5139511
CFAMM00141581 CHEMBL71425 Bioactive SureCN5772660
CFAMM00141705 CHEMBL159932 Bioactive AGN-PC-03MW3W
CFAMM00141624 DCL000284 Clinical Trial Drug RPR 200765A

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21794 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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