CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Macrophage colony-stimulating factor 1 Inhibitor ABT-869 Family
No. of Seeds 8 No. of Other Members 56
Family Centroid CFAMM00127840 Functional Category Clinical Trial Drug
Superfamily Macrophage colony-stimulating factor 1 Inhibitor ABT-869 Superfamily
Class Class 827

Cousin Family NamesSeedsMembers
Transient receptor potential cation channel subfamily V member... 12 108
NKP-1339 family 3 7
Cyclin-dependent kinase 2 Inhibitor N-(5-cyclopropyl-1h-pyrazo... 6 62
Tyrosine-protein kinase JAK2 Inhibitor 5-phenyl-1h-indazol-3-a... 1 7
Aurora kinase B and Aurora kinase C Inhibitor PHA-680632 Family 5 72
Glycogen synthase kinase-3 beta Inhibitor N-(6-chloro-5-p-toly... 5 9
Glycogen synthase kinase-3 beta Inhibitor N-(6-(3-hydroxypheny... 2 4
Glycogen synthase kinase-3 beta Inhibitor (e)-n-(6-(prop-1-eny... 3 0
Glycogen synthase kinase-3 beta Inhibitor N-(6-(thiophen-3-yl)... 4 3
Metabotropic glutamate receptor 5 Ligand N-(1,3-diphenyl-1h-py... 6 37
Mitogen-activated protein kinase kinase kinase kinase 5 and Du... 1 18
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
Serine/threonine-protein kinase 17A and Myosin light chain kin... 3 7
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 5 11
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 4 20
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 18
Cell division cycle 7-related protein kinase and Casein kinase... 2 0
Rho-associated protein kinase 1 and Ribosomal protein S6 kinas... 4 5
Serine/threonine-protein kinase PLK4 inhibitor 4-[(E)-2-[6-[(E... 2 3
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 10 9
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 4 4
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 6 6
Mitogen-activated protein kinase 14 inhibitor SureCN294394 family 2 6
Cell division cycle 7-related protein kinase and Dual specific... 3 0
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor 1-[6,6-dimet... 1 0
Aurora kinase A and Aurora kinase B inhibitor SureCN4059106 fa... 1 0
Neuropeptide Y receptor type 5 ligand 3-[3-[2-[[5-(4-chlorophe... 1 0
Vascular endothelial growth factor receptor 2 ligand 1-[4-[3-a... 1 0
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 1 0
Aurora kinase A and Tyrosine-protein kinase SYK inhibitor AGN-... 1 0


External ID

Functional Category

Molecule Name

CFAMM00127840 DCL000029 Clinical Trial Drug ABT-869
CFAMM00127871 DNC007169 Investigative Drug N-[4-(3-amino-1H-indazol-4-yl)phenyl]benzamide
CFAMM00127832 DNC010592 Investigative Drug N-(6-phenethyl-1H-indazol-3-yl)butyramide
CFAMM00127870 DNC007168 Investigative Drug 4-(4-aminophenyl)-1H-indazol-3yl-amine
CFAMM00127834 DNC010590 Investigative Drug N-(6-benzyl-1H-indazol-3-yl)butyramide
CFAMM00127872 DNC010578 Investigative Drug N-(6-(4-aminophenyl)-1H-indazol-3-yl)butyramide
CFAMM00127841 DNC010585 Investigative Drug N-(6-phenyl-1H-indazol-3-yl)butyramide
CFAMM00127833 DNC010591 Investigative Drug N-(6-(4-fluorophenyl)-1H-indazol-3-yl)butyramide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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