CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFCD191
Family Name DNA topoisomerase 2-beta Inhibitor TOP-53 Family
No. of Seeds 2 No. of Other Members 12
Family Centroid CFAMM00141892 Functional Category Clinical Trial Drug with Natural Product
Superfamily DNA topoisomerase 2-beta Binder Superfamily 2
Class Class 746

Cousin Family NamesSeedsMembers
DNA topoisomerase 2-beta Inhibitor Etoposide Family 3 29
Transient receptor potential cation channel subfamily V member... 29 18
Endothelin-1 receptor Ligand PD156707 Family 41 211
Platelet-activating factor receptor Ligand L-652731 Family 5 116
Endothelin B receptor and Endothelin-1 receptor Ligand PD-1631... 9 13
Arachidonate 15-lipoxygenase and Arachidonate 5-lipoxygenase I... 3 18
Arachidonate 12-lipoxygenase, 12S-type and Arachidonate 15-lip... 2 1
Cytochrome P450 3A4 Inhibitor (8r,8'r,9's)-5-methoxyclusin Family 6 20
Cytochrome P450 3A4 Inhibitor Hinokinin Family 2 10
Cytochrome P450 3A4 Inhibitor (-)-cubebininolide Family 4 28
NF-kappa-B Inhibitor Rocaglamide Family 8 8
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 6 6
Endothelin-1 receptor ligand (2S)-2-(1,3-benzodioxol-5-yl)-4-m... 17 0
Endothelin-1 receptor ligand SureCN8117947 family 1 3
Eukaryotic initiation factor 4A-I inhibitor methyl (1R,2R,3S,3... 12 1
Steroids and Steroid Derivatives Metabolite 2-Methoxyestrone 3... 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00141892 DCL000290 Clinical Trial Drug TOP-53
CFAMM00141914 DNC009179 Investigative Drug 4'-Demethyl-epipodophyllotoxin

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21767 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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